Cited by 403Lipid metabolism and biosynthesisCancer, Lipids, and MetabolismCholesterol and Lipid Metabolism

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Phosphatidic acid, a key intermediate in lipid metabolism

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Athenstaedt, Karin, Daum, Günther·1999·European Journal of Biochemistry

DOI 10.1046/j.1432-1327.1999.00822.x

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Abstract

Phosphatidic acid (PtdOH) is a key intermediate in glycerolipid biosynthesis. Two different pathways are known for de novo formation of this compound, namely (a) the Gro3P (glycerol 3-phosphate) pathway, and (b) the GrnP (dihydroxyacetone phosphate) pathway. Whereas the former route of PtdOH synthesis is present in bacteria and all types of eukaryotes, the GrnP pathway is restricted to yeast and mammalian cells. In this review article, we describe the enzymes catalyzing de novo formation of PtdOH, their properties and their occurrence in different cell types and organelles. Much attention has recently been paid to the subcellular localization of enzymes involved in the biosynthesis of PtdOH. In all eukaryotic cells, microsomes (ER) harbour the complete set of enzymes catalyzing these pathways and are thus the usual organelle for PtdOH formation. In contrast, the contribution of mitochondria to PtdOH synthesis is restricted to certain enzymes and depends on the cell type. In addition, chloroplasts of plants, lipid particles of the yeast, and peroxisomes of mammalian cells are significantly involved in PtdOH biosynthesis. Redundant systems of acyltransferases, the interplay of organelles, regulation of the pathway on the compartmental level, and finally the contribution of alternative pathways (phosphorylation of diacylglycerol and cleavage of phospholipids by phospholipases) to PtdOH biosynthesis appear to be required for the balanced formation of this important lipid intermediate. Dysfunction of enzymes involved in PtdOH synthesis can result in severe defects of various cellular processes. In this context, the possible physiological role(s) of PtdOH and its related metabolites, lysophosphatidic acid and diacylglycerol, will be discussed.

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A novel X-linked gene, G4.5. is responsible for Barth syndrome
Bione, S., D’Adamo, P., Maestrini, E., Gedeon, Á. K., Bolhuis, P. A., & Toniolo, D. (1996) · Nature Genetics · doi:10.1038/ng0496-385 · Cited by 753
Phospholipid synthesis and lipid composition of subcellular membranes in the unicellular eukaryote Saccharomyces cerevisiae
Zinser, E., Sperka-Gottlieb, C. D. M., Fasch, E.-V., Kohlwein, S. D., Paltauf, F., & Daum, G. (1991) · Journal of Bacteriology · doi:10.1128/jb.173.6.2026-2034.1991 · Cited by 705
Self-citation
An X-linked mitochondrial disease affecting cardiac muscle, skeletal muscle and neutrophil leucocytes
Barth, P. G., Scholte, H. R., BERDEN, J. A., Moorsel, J. M. V. D. K., Luyt‐Houwen, I. E. M., Veer-Korthof, E. T. V., van der Harten, J. J., & Sobotka, M. A. (1983) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(83)90209-5 · Cited by 702
Lysophosphatidic Acid, a Multifunctional Phospholipid Messenger
Moolenaar, W. H. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.22.12949 · Cited by 584
β-Oxidation of fatty acids in mitochondria, peroxisomes, and bacteria: A century of continued progress
Kunau, W. H. (1995) · Progress in Lipid Research · doi:10.1016/0163-7827(95)00011-9 · Cited by 516
AMP-activated kinase reciprocally regulates triacylglycerol synthesis and fatty acid oxidation in liver and muscle: evidence that sn-glycerol-3-phosphate acyltransferase is a novel target
Muoio, D. M., Seefeld, K. J., Witters, L. A., & Coleman, R. (1999) · Biochemical Journal · doi:10.1042/bj3380783 · Cited by 429
Phosphoglyceride Metabolism
van den BOSCH, H. (1974) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.43.070174.001331 · Cited by 418
EUKARYOTIC PHOSPHOLIPID BIOSYNTHESIS
Kent, C. (1995) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.64.070195.001531 · Cited by 381
GLYCEROLIPID BIOSYNTHESIS IN PEROXISOMES VIA THE ACYL DIHYDROXYACETONE PHOSPHATE PATHWAY*
Hajra, A. K., & Bishop, J. E. (1982) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1982.tb21415.x · Cited by 340
Modification of seed oil content and acyl composition in the brassicaceae by expression of a yeast sn-2 acyltransferase gene.
Zou, J., Katavić, V., Giblin, E. M., Barton, D. L., MacKenzie, S. L., Keller, W. A., Hu, X., & Taylor, D. C. (1997) · The Plant Cell · doi:10.1105/tpc.9.6.909 · Cited by 308

Show all 112 references

Research works printed but not linked: 5

Bell R.M., 1983, The Enzymes, 87
Gurr M.I., 1980, The Biochemistry of Plants, 205
Lightner V.A., 1980, Membrane phospholipid synthesis in, Escherichia coli. J. Biol. Chem., 255, 9413
Shiao Y.‐J., 1995, Regulation of mitochondrial and microsomal phospholipid synthesis by liver fatty acid‐binding protein., J. Biol. Chem., 267, 14353
Schutgens R.B.H., 1996, Emery and Rimoin’s Principals and Practice of Medical Genetics, 2131

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Authors: Athenstaedt, K., & Daum, G.
Affiliations: University of Graz (AT)
ORCID: Athenstaedt, Karin
Venue: European Journal of Biochemistry
Publisher: Wiley
Published: 1999-11-15
Volume: 266
Issue: 1
Pages: 1-16
ISSN: 0014-2956 (ISSN-L)
1432-1033
DOI: 10.1046/j.1432-1327.1999.00822.x
OpenAlex: W2001355405
Cited by: 403
References: 112
Citations by year: 2026: 10 · 2025: 14 · 2024: 15 · 2023: 13 · 2022: 10 · 2021: 18 · 2020: 16 · 2019: 31 · 2018: 16 · 2017: 18 · 2016: 25 · 2015: 23 · 2014: 17 · 2013: 22 · 2012: 15
FWCI: 1.04
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 771 d)
Locations: European Journal of Biochemistry (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Keywords: phosphatidic acid, glycerolipid biosynthesis, subcellular localization, endoplasmic reticulum, mitochondria, chloroplasts, peroxisomes, acyltransferase, lysophosphatidic acid, diacylglycerol, lipid metabolism
MeSH terms: Acyltransferases, Animals, Dihydroxyacetone Phosphate, Glycerophosphates, Lysophospholipids, Mammals, Microsomes, Phenotype, Phosphatidic Acids, Prokaryotic Cells, Organelles, Lipid Metabolism

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Phosphatidic acid, a key intermediate in lipid metabolism

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