The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Glutathione metabolism in brain: Metabolic interaction between astrocytes and neurons in the defense against reactive oxygen species
Open accessAbstract
The cells of the adult human brain consume ≈ 20% of the oxygen utilized by the body although the brain comprises only 2% of the body weight. Reactive oxygen species, which are produced continuously during oxidative metabolism, are generated at high rates within the brain. Therefore, the defense against the toxic effects of reactive oxygen species is an essential task within the brain. An important component of the cellular detoxification of reactive oxygen species is the antioxidant glutathione. The main focus of this short review is recent results on glutathione metabolism of brain astrocytes and neurons in culture. These two types of cell prefer different extracellular precursors for glutathione. Glutathione is involved in the disposal of exogenous peroxides by astrocytes and neurons. In coculture astrocytes protect neurons against the toxicity of reactive oxygen species. One mechanism of this interaction is the supply by astrocytes of glutathione precursors to neurons.
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Cites
Free Radicals in Biology and Medicine
Halliwell, B., & Gutteridge, J. M. C. (2015) · doi:10.1093/acprof:oso/9780198717478.001.0001 · Cited by 8,990
Metabolism and functions of glutathione in brain
Dringen, R. (2000) · Progress in Neurobiology · doi:10.1016/s0301-0082(99)00060-x · Cited by 1,702
Self-citationDringen, R., Pfeiffer, B., & Hamprecht, B. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-02-00562.1999 · Cited by 589
Self-citationKranich, O., Hamprecht, B., & Dringen, R. (1996) · Neuroscience Letters · doi:10.1016/s0304-3940(96)13217-1 · Cited by 110
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Cited by
Verkhratsky, A., & Nedergaard, M. (2018) · Physiological Reviews · doi:10.1152/physrev.00042.2016 · Cited by 1,678
Halliwell, B. (2001) · Drugs & Aging · doi:10.2165/00002512-200118090-00004 · Cited by 1,502
The role of oxidative stress in neurodegenerative diseases
Kim, G. H., Kim, J. E., Rhie, S. J., & Yoon, S. (2015) · Experimental Neurobiology · doi:10.5607/en.2015.24.4.325 · Cited by 1,355
New clues about vitamin D functions in the nervous system
Garcion, E., Wion-Barbot, N., Montero-Menei, C. N., Berger, F., & Wion, D. (2002) · Trends in Endocrinology & Metabolism · doi:10.1016/s1043-2760(01)00547-1 · Cited by 904
Shih, A. Y., Johnson, D. A., Wong, G., Kraft, A. D., Jiang, L., Erb, H., Johnson, J. A., & Murphy, T. H. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-08-03394.2003 · Cited by 785
Metadata
- Authors
- Dringen, R., Gutterer, J. M., & Hirrlinger, J.
- Venue
- European Journal of Biochemistry
- Publisher
- Wiley
- Published
- 2000-08
- Volume
- 267
- Issue
- 16
- Pages
- 4912-4916
- ISSN
- 0014-2956 (ISSN-L)
- 1432-1033
- OpenAlex
- W1791420399
- Cited by
- 760
- References
- 4
- FWCI
- 7.79
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Dringen, R., Gutterer, J. M., & Hirrlinger, J. (2000). Glutathione metabolism in brain: Metabolic interaction between astrocytes and neurons in the defense against reactive oxygen species. European Journal of Biochemistry. https://doi.org/10.1046/j.1432-1327.2000.01597.x
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