The role of oxidative stress in neurodegenerative diseases

Kim, Geon Ha; Kim, Jieun E.; Rhie, Sandy Jeong; Yoon, Sujung

doi:10.5607/en.2015.24.4.325

Cited by 1,355Antioxidant Activity and Oxidative StressRedox biology and oxidative stressParkinson's Disease Mechanisms and Treatments

The role of oxidative stress in neurodegenerative diseases

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Kim, Geon Ha, Kim, Jieun E., Rhie, Sandy Jeong, Yoon, Sujung·2015·Experimental Neurobiology

DOI 10.5607/en.2015.24.4.325PMC PMC4688332

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Abstract

Oxidative stress is induced by an imbalanced redox states, involving either excessive generation of reactive oxygen species (ROS) or dysfunction of the antioxidant system. The brain is one of organs especially vulnerable to the effects of ROS because of its high oxygen demand and its abundance of peroxidation-susceptible lipid cells. Previous studies have demonstrated that oxidative stress plays a central role in a common pathophysiology of neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. Antioxidant therapy has been suggested for the prevention and treatment of neurodegenerative diseases, although the results with regard to their efficacy of treating neurodegenerative disease have been inconsistent. In this review, we will discuss the role of oxidative stress in the pathophysiology of neurodegenerative diseases and in vivo measurement of an index of damage by oxidative stress. Moreover, the present knowledge on antioxidant in the treatment of neurodegenerative diseases and future directions will be outlined.

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Oxidative stress is part of AD pathology as Aβ42 neurotoxicity leads to induction of reactive oxygen species and other free radicals, which may escalate production and deposition of Aβ and phosphorylation and polymerization of tau.
“Oxidative stress is part of AD pathology as Aβ42 neurotoxicity leads to induction of reactive oxygen species and other free radicals, which in turn may escalate production and deposition of Aβ and phosphorylation and polymerization of tau (Kim et al., 2015).”
From Alzheimer's-associated PU.1 expression levels regulate microglial inflammatory response (2021) · cites this paper as Kim et al., 2015
The Alzheimer’s disease section says Aβ accumulation may increase oxidative stress and ROS, while oxidative stress can increase Aβ production and deposition and promote tau phosphorylation. It does not specifically identify Aβ42 as the cause or say that oxidative stress promotes tau polymerization. Page numbers were not provided in our copy. (LLM, conf=0.87)
Experimental — accuracy not yet measured
Oxidative stress acts as a vehicle for deposition and accumulation of amyloid β in AD through production of reactive oxygen species.
“Evidence indicates that, through production of reactive oxygen species, oxidative stress acts as vehicle for deposition and accumulation of amyloid β (Aβ) in AD (Kim et al., 2015).”
From Effect of Probiotic Supplementation on Cognitive Function and Metabolic Status in Alzheimer's Disease: A Randomized, Double-Blind and Controlled Trial (2016) · cites this paper as Kim et al., 2015
Various investigations have shown that nutraceuticals are capable of fulfilling neuroprotective functions on molecular mechanisms that trigger Alzheimer's disease, acting as antioxidants or anti-neuroinflammatory drugs, affecting aggregation of β amyloid peptides, hyperphosphorylation of Tau protein, and decrease of acetylcholine in cholinergic neurons.
“Various investigations have shown that nutraceuticals are capable of fulfilling neuroprotective functions on molecular mechanisms that trigger AD, acting as antioxidants or anti-neuroinflammatory drugs, taking effect on the aggregation of β amyloid peptides, the hyperphosphorylation of the Tau protein and the decrease of the neurotransmitter ACh in cholinergic neurons [70,71,72]”
From Multi-Target Mechanisms of Phytochemicals in Alzheimer’s Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation (2022) · cites this paper as [72]
In Alzheimer's disease, excessive oxidative stress manifests from the early stages of the disease.
“Particularly for AD, excessive OS manifests itself from the early stages of the disease [72,125].”
From Multi-Target Mechanisms of Phytochemicals in Alzheimer’s Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation (2022) · cites this paper as [72]
ROS are postulated to be the main cause of neurological deterioration, triggering pathologies such as Alzheimer's disease, Parkinson's disease, and Huntington's disease.
“ROS have been postulated to be the main cause of neurological deterioration, triggering pathologies such as AD, Parkinson’s disease (PD), and Huntington’s disease (HD) [72,116,124].”
From Multi-Target Mechanisms of Phytochemicals in Alzheimer’s Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation (2022) · cites this paper as [72]

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Background
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An Overview of Oxidative Stress, Neuroinflammation, and Neurodegenerative Diseases
Teleanu, D. M., Niculescu, A.-G., Lungu, I. I., Radu, C. I., Vladâcenco, O., Roza, E., Costăchescu, B., Grumezescu, A. M., & Teleanu, R. I. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23115938 · Cited by 1,085 · see citing works
Effect of Probiotic Supplementation on Cognitive Function and Metabolic Status in Alzheimer's Disease: A Randomized, Double-Blind and Controlled Trial
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Oxidative Stress in Neurodegenerative Diseases: From Molecular Mechanisms to Clinical Applications
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Ageing, age-related diseases and oxidative stress: What to do next?
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NADPH oxidase in brain injury and neurodegenerative disorders
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Bioactive compounds from date fruit and seed as potential nutraceutical and functional food ingredients
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Nanotechnology: A Promising Approach for Delivery of Neuroprotective Drugs
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Oxidative Stress and Huntington’s Disease: The Good, the Bad, and the Ugly
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NCOA4-Mediated Ferritinophagy: A Potential Link to Neurodegeneration
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The pleiotropic neuroprotective effects of resveratrol in cognitive decline and Alzheimer’s disease pathology: From antioxidant to epigenetic therapy
Griñán-Ferré, C., Bellver-Sanchis, A., Izquierdo, V., Corpas, R., Roig-Soriano, J., Chillón, M., Andres-Lacueva, C., Somogyvári, M., Sőti, C., Sanfeliu, C., et al. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101271 · Cited by 208 · see citing works
Getting to the Heart of Alzheimer Disease
Tublin, J. M., Adelstein, J. M., del Monte, F., Combs, C. K., & Wold, L. E. (2019) · Circulation Research · doi:10.1161/circresaha.118.313563 · Cited by 188 · see citing works
Sodium—Glucose cotransporter inhibitors and oxidative stress: An update
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Alzheimer's-associated PU.1 expression levels regulate microglial inflammatory response
Pimenova, A. A., Herbinet, M., Gupta, I., Machlovi, S. I., Bowles, K. R., Marcora, E., & Goate, A. M. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.105217 · Cited by 141 · see citing works
Effect of smoking cessation on the risk of dementia: a longitudinal study
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Upstream regulators and downstream effectors of NF-κB in Alzheimer’s disease
Shi, Z.-M., Han, Y.-W., Han, X.-H., Zhang, K., Chang, Y.-N., Hu, Z.-M., Qi, H.-X., Ting, C., Zhen, Z., & Hong, W. (2016) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2016.05.022 · Cited by 125 · see citing works
Multi-Target Mechanisms of Phytochemicals in Alzheimer’s Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation
Sharifi-Rad, J., Rapposelli, S., Sestito, S., Herrera-Bravo, J., Arancibia-Diaz, A., Salazar, L. A., Yeskaliyeva, B., Beyatli, A., Leyva-Gómez, G., González-Contreras, C., et al. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12091515 · Cited by 125 · see citing works
“However, when the hyperphosphorylated Tau protein is overexpressed (which is a pathophysiological indicator of AD) a depletion of these organelles has been evidenced, suggesting it is the cause of H2O2 and ROS increase [72,108,126].”
Background
Plants-derived neuroprotective agents: cutting the cycle of cell death through multiple mechanisms
Elufioye, T. O., Berida, T. I., & Habtemariam, S. (2017) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2017/3574012 · Cited by 107 · see citing works
Intranasal Delivery of Genistein-Loaded Nanoparticles as a Potential Preventive System against Neurodegenerative Disorders
Rassu, G., Porcu, E. P., Fancello, S., Obinu, A., Senes, N., Galleri, G., Migheli, R., Gavini, E., & Giunchedi, P. (2018) · Pharmaceutics · doi:10.3390/pharmaceutics11010008 · Cited by 107 · see citing works
Multitarget‐Directed Ligands Combining Cholinesterase and Monoamine Oxidase Inhibition with Histamine H3R Antagonism for Neurodegenerative Diseases
Bautista‐Aguilera, Ó. M., Hagenow, S., Palomino‐Antolin, A., Farré‐Alins, V., Ismaili, L., Joffrin, P., Jimeno, M. L., Soukup, O., Janočková, J., Kalinowsky, L., et al. (2017) · Angewandte Chemie International Edition · doi:10.1002/anie.201706072 · Cited by 105 · see citing works
Next-generation DNA damage sequencing
Mingard, C., Wu, J., McKeague, M., & Sturla, S. J. (2020) · Chemical Society Reviews · doi:10.1039/d0cs00647e · Cited by 92 · see citing works
Oxidative Damage and Antioxidant Response in Frontal Cortex of Demented and Nondemented Individuals with Alzheimer’s Neuropathology
Fracassi, A., Marcatti, M., Zolochevska, O., Tabor, N., Woltjer, R., Moreno, S., & Taglialatela, G. (2021) · The Journal of Neuroscience · doi:10.1523/jneurosci.0295-20.2020 · Cited by 81 · see citing works
Physical Exercise-Induced Myokines in Neurodegenerative Diseases
Lee, B., Shin, M., Park, Y., Won, S.-Y., & Cho, K. S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115795 · Cited by 79 · see citing works
A review on therapeutic potentials of Trigonella foenum graecum (fenugreek) and its chemical constituents in neurological disorders: Complementary roles to its hypolipidemic, hypoglycemic, and antioxidant potential
Zameer, S., Najmi, A. K., Vohora, D., & Akhtar, M. (2018) · Nutritional Neuroscience · doi:10.1080/1028415x.2017.1327200 · Cited by 74 · see citing works
Towards a comprehensive theory of obesity and a healthy diet: The causal role of oxidative stress in food addiction and obesity
Tobore, T. O. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112560 · Cited by 73 · see citing works
Physical Activity and Oxidative Stress in Aging
Militello, R., Luti, S., Gamberi, T., Pellegrino, A., Modesti, A., & Modesti, P. A. (2024) · doi:10.20944/preprints202404.0293.v1 · Cited by 73 · see citing works
Urinary Biomarkers for Neurodegenerative Diseases
Seol, W., Kim, H., & Son, I. (2020) · Experimental Neurobiology · doi:10.5607/en20042 · Cited by 61 · see citing works
Directly converted astrocytes retain the ageing features of the donor fibroblasts and elucidate the astrocytic contribution to human CNS health and disease.
Gatto, N., Dos Santos Souza, C., Shaw, A. C., Bell, S. M., Myszczynska, M. A., Powers, S., Meyer, K., Castelli, L. M., Karyka, E., Mortiboys, H., et al. (2021) · Aging Cell · doi:10.1111/acel.13281 · Cited by 58 · see citing works
Probiotics and the Treatment of Parkinson's Disease: An Update
Mirzaei, H., Sedighi, S., Kouchaki, E., Barati, E., Dadgostar, E., Aschner, M., & Tamtaji, O. R. (2022) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-021-01128-w · Cited by 57 · see citing works
Deletion of NADPH oxidase 4 reduces severity of traumatic brain injury
Ma, M. W., Wang, J., Dhandapani, K. M., & Brann, D. W. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.01.031 · Cited by 52 · see citing works
miR-124: A Promising Therapeutic Target for Central Nervous System Injuries and Diseases
Xu, J., Zheng, Y., Wang, L., Liu, Y., Wang, X., Li, Y., & Chi, G. (2022) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-021-01091-6 · Cited by 55 · see citing works
Walnut Oil Prevents Scopolamine-Induced Memory Dysfunction in a Mouse Model
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Authors: Kim, G. H., Kim, J. E., Rhie, S. J., & Yoon, S.
Affiliations: Ewha Womans University (KR)
Corresponding author: Yoon, Sujung
ORCID: Kim, Geon Ha
Rhie, Sandy Jeong
Yoon, Sujung
Venue: Experimental Neurobiology
Publisher: The Korean Society for Brain and Neural Science
Published: 2015-12-30
Volume: 24
Issue: 4
Pages: 325-340
ISSN: 1226-2560 (ISSN-L)
2093-8144
DOI: 10.5607/en.2015.24.4.325
PMC: PMC4688332
OpenAlex: W2185348657
Cited by: 1,355
References: 143
Citations by year: 2026: 53 · 2025: 108 · 2024: 142 · 2023: 124 · 2022: 135 · 2021: 167 · 2020: 187 · 2019: 171 · 2018: 103 · 2017: 114 · 2016: 49 · 2013: 1
FWCI: 9.29
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: creativecommons.org/licenses/by-nc/3.0/ (tdm)
Locations: Experimental Neurobiology (publishedVersion)
PubMed Central (publishedVersion, cc-by-nc)
PubMed (publishedVersion)
Funders: MSIP (B0132-15-1001)
Topics: Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
Keywords: oxidative stress, neurodegenerative diseases, reactive oxygen species, antioxidant defense, antioxidant therapy, Alzheimer's disease, Parkinson's disease, lipid peroxidation, oxidative damage biomarkers, redox imbalance

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