The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Methyl‐CpG‐binding proteins: Targeting specific gene repression
Open accessAbstract
CpG methylation, the most common epigenetic modification of vertebrate genomes, is primarily associated with transcriptional repression. MeCP2, MBD1, MBD2, MBD3 and MBD4 constitute a family of vertebrate proteins that share the methyl‐CpG‐binding domain (MBD). The MBD, consisting of about 70 residues, possesses a unique α/β‐sandwich structure with characteristic loops, and is able to bind single methylated CpG pairs as a monomer. All MBDs except MBD4, an endonuclease that forms a complex with the DNA mismatch‐repair protein MLH1, form complexes with histone deacetylase. It has been established that MeCP2, MBD1 and MBD2 are involved in histone deacetylase‐dependent repression and it is likely that this is also the case for MBD3. The current model proposes that MBD proteins are involved in recruiting histone deacetylases to methyl CpG‐enriched regions in the genome to repress transcription. The lack of selectivity for MBD association with particular DNA sequences indicates that other mechanisms account for their recruitment to particular regions in the genome.
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Cites
Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2
Amir, R. E., Van den Veyver, I. B., Wan, M., Tran, C. Q., Francke, U., & Zoghbi, H. Y. (1999) · Nature Genetics · doi:10.1038/13810 · Cited by 4,990
Nan, X., Ng, H.-H., Johnson, C. A., Laherty, C. D., Turner, B. M., Eisenman, R. N., & Bird, A. (1998) · Nature · doi:10.1038/30764 · Cited by 3,440
Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription
Jones, P. L., Veenstra, G. J. C., Wade, P. A., Vermaak, D., Kass, S. U., Landsberger, N., Strouboulis, J., & Wolffe, A. P. (1998) · Nature Genetics · doi:10.1038/561 · Cited by 2,730
Self-citationIdentification and Characterization of a Family of Mammalian Methyl-CpG Binding Proteins
Hendrich, B., & Bird, A. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.11.6538 · Cited by 1,360
MeCP2 Is a Transcriptional Repressor with Abundant Binding Sites in Genomic Chromatin
Nan, X., Campoy, F. J., & Bird, A. (1997) · Cell · doi:10.1016/s0092-8674(00)81887-5 · Cited by 1,275
Zhang, Y., Ng, H.-H., Erdjument-Bromage, H., Tempst, P., Bird, A., & Reinberg, D. (1999) · Genes & Development · doi:10.1101/gad.13.15.1924 · Cited by 1,103
The essentials of DNA methylation
Bird, A. (1992) · Cell · doi:10.1016/0092-8674(92)90526-i · Cited by 948
MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex
Ng, H.-H., Zhang, Y., Hendrich, B., Johnson, C. A., Turner, B. M., Erdjument-Bromage, H., Tempst, P., Reinberg, D., & Bird, A. (1999) · Nature Genetics · doi:10.1038/12659 · Cited by 936
DNA methylation and gene activity
Cedar, H. (1988) · Cell · doi:10.1016/0092-8674(88)90479-5 · Cited by 886
De novo DNA cytosine methyltransferase activities in mouse embryonic stem cells
Lei, H., Oh, S. P., Okano, M., Jüttermann, R., Goss, K. A., Jaenisch, R., & Li, E. (1996) · Development · doi:10.1242/dev.122.10.3195 · Cited by 816
Cited by
Youngblood, B., Oestreich, K. J., Ha, S.-J., Duraiswamy, J., Akondy, R. S., West, E. E., Wei, Z., Lu, P., Austin, J. W., Riley, J. L., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.06.015 · Cited by 419
N-CoR Mediates DNA Methylation-Dependent Repression through a Methyl CpG Binding Protein Kaiso
Yoon, H.-G., Chan, D. W., Reynolds, A. B., Qin, J., & Wong, J. (2003) · Molecular Cell · doi:10.1016/j.molcel.2003.08.008 · Cited by 408
Modifications of structures and functions of caseins: a scientific and technological challenge.
Broyard, C., & Gaucheron, F. (2015) · Dairy Science & Technology · doi:10.1007/s13594-015-0220-y · Cited by 347
Rett syndrome in Australia: A review of the epidemiology
Laurvick, C. L., de Klerk, N., Bower, C., Christodoulou, J., Ravine, D., Ellaway, C., Williamson, S., & Leonard, H. (2006) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2005.10.037 · Cited by 340
Methyl-CpG binding proteins identify novel sites of epigenetic inactivation in human cancer
Ballestar, E. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg604 · Cited by 320
Self-citation
Metadata
- Authors
- Ballestar, E., & Wolffe, A. P.
- Venue
- European Journal of Biochemistry
- Publisher
- Wiley
- Published
- 2001-01
- Volume
- 268
- Issue
- 1
- Pages
- 1-6
- ISSN
- 0014-2956 (ISSN-L)
- 1432-1033
- OpenAlex
- W1608490912
- Cited by
- 408
- References
- 37
- FWCI
- 14.98
- Type
- journal article
- Language
- en
- Open access
- bronze
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