The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Receptor mediated uptake of peptides that bind the human transferrin receptor
Open accessAbstract
A biopanning process designed to find peptide epitopes specific for cell surface receptors has been used in this study to select seven‐ and 12‐amino‐acid peptides capable of binding to and internalizing with the human transferrin receptor (hTfR). Through sequential rounds of negative and positive selection, two peptide sequences were identified that specifically bind to the hTfR. Phage containing the sequences HAIYPRH or THRPPMWSPVWP were inhibited from binding the hTfR in a dose‐dependent fashion when peptides of the same sequence were present in a competition assay. Interestingly, transferrin did not compete with either of these sequences for receptor binding, suggesting that these peptides bind a site on the hTfR distinct from the transferrin binding site. When either of these sequences was expressed as a fusion to green fluorescent protein (GFP), the recombinant GFP molecule was internalized in cells expressing the hTfR. These studies suggest that the two peptides can be used to target other proteins into the endosomal pathway. Further, they provide a strategy for identifying peptides that bind to other cell surface receptors that can be used for both diagnostic and therapeutic purposes.
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de Boer, A. G., & Gaillard, P. J. (2007) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.47.120505.105237 · Cited by 348
Zhou, Y., Chen, X., Cao, J., & Gao, H. (2020) · Journal of Materials Chemistry B · doi:10.1039/d0tb00649a · Cited by 213
Nakase, I., Lai, H., Singh, N. P., & Sasaki, T. (2008) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2007.09.003 · Cited by 190
Liang, Y., Iqbal, Z., Lu, J., Wang, J., Zhang, H., Chen, X., Duan, L., & Xia, J. (2023) · Molecular Therapy · doi:10.1016/j.ymthe.2022.10.008 · Cited by 162
Peptide-Functionalized Lipid Nanoparticles for Targeted Systemic mRNA Delivery to the Brain
Han, E. L., Tang, S., Kim, D., Murray, A. M., Swingle, K. L., Hamilton, A. G., Mrksich, K., Padilla, M. S., Palanki, R., Li, J. J., et al. (2025) · Nano Letters · doi:10.1021/acs.nanolett.4c05186 · Cited by 158
Metadata
- Authors
- Lee, J. H., Engler, J. A., Collawn, J. F., & Moore, B. A.
- Venue
- European Journal of Biochemistry
- Publisher
- Wiley
- Published
- 2001-04
- Volume
- 268
- Issue
- 7
- Pages
- 2004-2012
- ISSN
- 0014-2956 (ISSN-L)
- 1432-1033
- OpenAlex
- W4256220055
- Cited by
- 280
- References
- 22
- FWCI
- 0.87
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Lee, J. H., Engler, J. A., Collawn, J. F., & Moore, B. A. (2001). Receptor mediated uptake of peptides that bind the human transferrin receptor. European Journal of Biochemistry. https://doi.org/10.1046/j.1432-1327.2001.02073.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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