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Cited by 63Biochemical Acid Research StudiesAntioxidant Activity and Oxidative StressAldose Reductase and Taurine

Effect Of α‐Lipoic Acid On Lipid Peroxidation And Anti‐Oxidant Enzyme Activities In Diabetic Rats

Dinçer, Yıldız, Telci, Ayşegül, Kayalı, Refik, Yılmaz, İlker A, Çakatay, Ufuk, Akçay, Tülay·2002·Clinical and Experimental Pharmacology and Physiology
DOI 10.1046/j.1440-1681.2002.03642.x
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Abstract

SUMMARY: 1. Oxidative damage has been suggested to be a contributory factor in the development and complications of diabetes. Recently, α‐lipoic acid (ALA) has gained considerable interest as an anti‐oxidant. Various studies have indicated the anti‐ oxidant effects of ALA and its reduced form dihydrolipoic acid. Therefore, it appears that these compounds have important therapeutic potential in conditions where oxidative stress is involved. The aim of the present study was to investigate the effect of ALA supplementation on lipid peroxidation and anti‐oxidant enzyme activities in various tissues in diabetic rats. 2. Male Wistar rats were divided into three groups. Diabetes was induced by streptozotocin (STZ) injection in the two groups of rats to be supplemented and not to be supplemented with ALA. Another group of rats, which received saline injection, formed the control group. After 5 weeks of diabetes, rats were killed. In order to assess the redox status of various organs in the diabetic and control rats, thiobarbituric acid‐reactive substances (TBARS) and glutathione (GSH) levels, as well as superoxide dismutase (SOD), glutathione peroxidase (G‐Px) and glutathione reductase (G‐Red) activities were determined in the liver, pancreas and kidney. 3. In both diabetic groups, TBARS levels and SOD activity were increased in the liver and pancreas, G‐Px and G‐Red activities were increased in the kidney and GSH levels were decreased in all organs compared with controls. In the ALA‐ supplemented group, TBARS levels were decreased, GSH levels were increased in the liver and pancreas, SOD activity was decreased in the liver, G‐Px activity remained unchanged in all tissues and G‐Red activity was increased in the pancreas compared with the diabetic group that did not receive ALA supplementation. 4. In conclusion, ALA supplementation has disparate effects on the redox status of different organs. These data are not sufficient for confirmation the beneficial effects of ALA supplementation on the redox status of various organs in diabetic rats.

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Authors
Dinçer, Y., Telci, A., Kayalı, R., Yılmaz, İ. A., Çakatay, U., & Akçay, T.
Affiliations
Istanbul University-Cerrahpaşa (TR)
Corresponding author
Dinçer, Yıldız
ORCID
Venue
Clinical and Experimental Pharmacology and Physiology
Publisher
Wiley
Published
2002-03-05
Volume
29
Issue
4
Pages
281-284
ISSN
  • 0305-1870 (ISSN-L)
  • 1440-1681
DOI
10.1046/j.1440-1681.2002.03642.x
OpenAlex
W2110130215
Cited by
63
References
24
Citations by year
2026: 1 · 2025: 3 · 2024: 2 · 2023: 3 · 2021: 1 · 2020: 2 · 2016: 1 · 2015: 3 · 2014: 5 · 2013: 4 · 2012: 2
FWCI
1.91
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Clinical and Experimental Pharmacology and Physiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Biochemical Acid Research Studies
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Aldose Reductase and Taurine
Keywords
alpha-lipoic acid, lipid peroxidation, antioxidant enzymes, oxidative stress, diabetes mellitus, streptozotocin-induced diabetes, dihydrolipoic acid, superoxide dismutase, glutathione peroxidase, glutathione reductase, glutathione, TBARS, liver, pancreas, kidney, redox state
MeSH terms
Animals, Antioxidants, Diabetes Mellitus, Experimental, Enzyme Activation, Glutathione Peroxidase, Glutathione Reductase, Thioctic Acid, Male, Superoxide Dismutase, Lipid Peroxidation, Up-Regulation, Rats, Wistar, Rats

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