Studies on heat shock proteins in sea urchin development
Abstract
Work on stress proteins in sea urchin embryos carried out over the last 20 years is reviewed and the following major results are described. Entire sea urchin embryos, if subjected to a rise in temperature at any postblastular stage undergo a wave of heat shock protein (hsp) synthesis and survive. If subjected to the same rise between fertilization and blastula formation, they are not yet able to synthesize hsp and die. Four clones coding for the major hsp, hsp70, have been isolated and sequenced; evidence for the existence of a heat shock factor has been provided, and a mechanism for the developmental regulation of hsp synthesis discussed. Intraembryonic and intracellular hsp location has been described; and a mechanism for achievement of thermotolerance proposed. A chaperonine role for a constitutive mitochondrial hsp56 has been suggested, as well as a role for the constitutive hsp70 in cell division. Heat shock, if preceded by 12-O-tetradecanoylphorbol-12-acetate (TPA) treatment causes apoptosis.
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Some defense gene products may be packaged into eggs during oogenesis to provide adequate defense during early cleavage stages.
“Some defense gene products may be packaged into eggs during oogenesis to provide adequate defense during early cleavage stages when divisions are rapid and nucleus:cytoplasm ratios are low (Epel, 2003;Giudice et al., 1999;Hamdoun et al., 2004), a period in which gene expression is unlikely to result in efficient upregulation of protein concentration.”
From The chemical defensome: Environmental sensing and response genes in the Strongylocentrotus purpuratus genome (2006) · cites this paper as Giudice et al., 1999
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- Authors
- Giudice, G., Sconzo, G., & Roccheri, M. C.
- Affiliations
- University of Palermo (IT)
- Venue
- Development, Growth & Differentiation
- Publisher
- Wiley
- Published
- 1999-08
- Volume
- 41
- Issue
- 4
- Pages
- 375-380
- ISSN
- 0012-1592 (ISSN-L)
- 1440-169X
- OpenAlex
- W2044005418
- Cited by
- 44
- References
- 26
- Citations by year
- 2025: 1 · 2021: 3 · 2019: 2 · 2018: 2 · 2016: 3 · 2015: 2 · 2014: 6 · 2013: 1 · 2012: 1
- FWCI
- 0.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Development Growth & Differentiation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Physical Sciences › Environmental Science › Ecology › Physiological and biochemical adaptations
- Keywords
- heat shock proteins, sea urchin embryo, HSP70, heat shock transcription factor, heat tolerance, developmental gene expression, hsp56, chaperonin, cell division, apoptosis, stress proteins
- MeSH terms
- Animals, Carcinogens, Embryo, Nonmammalian, Sea Urchins, Tetradecanoylphorbol Acetate, Apoptosis, Gene Expression Regulation, Developmental, HSP70 Heat-Shock Proteins
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