The DOI matches its Crossref record; 80 of the 82 references it cites were found in a registry or an index.
Bronchopulmonary afferent nerves.
Open accessAbstract
Abstract: Vagal afferent nerves are the primary communication pathways between the bronchopulmonary system and the central nervous system. Input from airway afferent nerves to the CNS is integrated in the brainstem and ultimately leads to sensations and various reflex outputs. Afferent nerves innervating the airways can be classified into various distinct phenotypes. However, there is no single classification scheme that takes all features, including conduction velocity, cell body diameter, ganglionic origin, and stimuli to which they respond (modality) into account. At present, bronchopulmonary afferent nerves are typically considered to belong to one of three general categories, namely C‐fibres, rapidly adapting stretch receptors (RARs), and slowly adapting stretch receptors (SARs). As our understanding of bronchopulmonary afferent nerves continues to deepen, we are likely to see more sophisticated classification schemes emerge. It is clear that the function of afferent fibres can be substantively influenced by airway inflammation and remodelling. The perturbations and perversions of afferent nerve function that occur during these states almost certainly contributes to many of the signs and symptoms of inflammatory airway disease. A more lucid characterization of bronchopulmonary afferent nerves, and a better understanding of the mechanisms by which these nerves influence pulmonary physiology during health and disease anticipates future research.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Cardiovascular and respiratory afferents activated by breathing are known to project to second-order relay neurons in brainstem autonomic regions, most notably the NTS via the vagus nerve (Malpas, 2002; Carr and Undem, 2003; Kubin et al., 2006).”
From Hypothesis: Pulmonary Afferent Activity Patterns During Slow, Deep Breathing Contribute to the Neural Induction of Physiological Relaxation (2019) · cites this paper as Carr and Undem, 2003
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“RARs have phasic responses to large lung inflations and deflations (Kubin et al., 2006), whereas SARs respond to large hyperinflations (e.g., 30 cm H2O) throughout the duration of the stimulus (Figure 1) (Carr and Undem, 2003).”
From Hypothesis: Pulmonary Afferent Activity Patterns During Slow, Deep Breathing Contribute to the Neural Induction of Physiological Relaxation (2019) · cites this paper as Carr and Undem, 2003
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Vagal sensory receptors and their reflex effects.
Paintal, A. S. (1973) · Physiological Reviews · doi:10.1152/physrev.1973.53.1.159 · Cited by 974
Conduction velocity is related to morphological cell type in rat dorsal root ganglion neurones.
Harper, A. A., & Lawson, S. N. (1985) · The Journal of Physiology · doi:10.1113/jphysiol.1985.sp015573 · Cited by 745
Afferent vagal C fibre innervation of the lungs and airways and its functional significance
Coleridge, J. C. G., & Coleridge, H. M. (1984) · Reviews of Physiology, Biochemistry and Pharmacology · doi:10.1007/bfb0027715 · Cited by 712
Contributions of placodal and neural crest cells to avian cranial peripheral ganglia
D'amico‐Martel, A., & Noden, D. M. (1983) · American Journal of Anatomy · doi:10.1002/aja.1001660406 · Cited by 704
Vertebrate Cranial Placodes I. Embryonic Induction
Baker, C. V. H., & Bronner-Fraser, M. E. (2001) · Developmental Biology · doi:10.1006/dbio.2001.0156 · Cited by 597
Neumann, S., Doubell, T. P., Leslie, T., & Woolf, C. J. (1996) · Nature · doi:10.1038/384360a0 · Cited by 585
Afferent properties and reflex functions of bronchopulmonary C-fibers
Lee, L.-Y., & Pisarri, T. E. (2001) · Respiration Physiology · doi:10.1016/s0034-5687(00)00204-8 · Cited by 372
Kummer, W., Fischer, A., Kurkowski, R., & Heym, C. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90239-x · Cited by 308
Villars, F., Guillotin, B., Amédée, T., Dutoya, S., Bordenave, L., Bareille, R., & Amédée, J. (2002) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00310.2001 · Cited by 305
Bradykinin-induced bronchoconstriction in humans. Mode of action.
Fuller, R. W., Dixon, C. M. S., Cuss, F. M., & Barnes, P. J. (1987) · PubMed · doi:10.1164/arrd.1987.135.1.176 · Cited by 254
Research works printed but not linked: 6
- Widdicombe JG., 1981, Regulation of Breathing, 429
- Darian‐Smith I., 1984, Handbook of Physiology, 739
- Darian‐Smith I., 1984, Handbook of Physiology, 879
- Mazzone SB, 2002, Plasticity of the cough reflex, Eur. Respir. Rev., 12, 236
- Patton HD., 1968, Neurophysiology, 95
- Fuortes MGF., 1971, Handbook of Sensory Neurophysiology, 243
Cited by
Piezos thrive under pressure: mechanically activated ion channels in health and disease
Murthy, S. E., Dubin, A. E., & Patapoutian, A. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.92 · Cited by 582
Central pathways of pulmonary and lower airway vagal afferents.
Kubin, L., Alheid, G. F., Zuperku, E. J., & McCrimmon, D. R. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00252.2006 · Cited by 477
Vagal Sensory Neuron Subtypes that Differentially Control Breathing
Chang, R. B., Strochlic, D. E., Williams, E. K., Umans, B. D., & Liberles, S. D. (2015) · Cell · doi:10.1016/j.cell.2015.03.022 · Cited by 451
An Atlas of Vagal Sensory Neurons and Their Molecular Specialization
Kupari, J., Häring, M., Agirre, E., Castelo‐Branco, G., & Ernfors, P. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.04.096 · Cited by 452
Piezo2 senses airway stretch and mediates lung inflation-induced apnoea
Nonomura, K., Woo, S.-H., Chang, R. B., Gillich, A., Qiu, Z., Francisco, A. G., Ranade, S. S., Liberles, S. D., & Patapoutian, A. (2017) · Nature · doi:10.1038/nature20793 · Cited by 428
Metadata
- Authors
- CARR, M. J., & UNDEM, B. J.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- CARR, Michael J.
- Venue
- Respirology
- Publisher
- Wiley
- Published
- 2003-08-07
- Volume
- 8
- Issue
- 3
- Pages
- 291-301
- ISSN
- 1323-7799 (ISSN-L)
- 1440-1843
- OpenAlex
- W1972490783
- Cited by
- 147
- References
- 82
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 4 · 2023: 5 · 2022: 11 · 2021: 10 · 2020: 14 · 2019: 7 · 2018: 7 · 2017: 4 · 2016: 3 · 2015: 4 · 2014: 6 · 2013: 7 · 2012: 3
- FWCI
- 0.94
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Respirology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory and Cough-Related Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Keywords
- vagal afferents, airway sensory nerves, C-fibers, airway inflammation, airway remodeling, inflammatory airway disease, airway reflexes
- MeSH terms
- Afferent Pathways, Bronchi, Humans, Lung, Neural Conduction, Neuronal Plasticity, Pulmonary Stretch Receptors, Respiratory System, Sneezing, Neurotransmitter Agents
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
