The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Vagal Afferent Innervation of the Airways in Health and Disease
Open accessAbstract
Vagal sensory neurons constitute the major afferent supply to the airways and lungs. Subsets of afferents are defined by their embryological origin, molecular profile, neurochemistry, functionality, and anatomical organization, and collectively these nerves are essential for the regulation of respiratory physiology and pulmonary defense through local responses and centrally mediated neural pathways. Mechanical and chemical activation of airway afferents depends on a myriad of ionic and receptor-mediated signaling, much of which has yet to be fully explored. Alterations in the sensitivity and neurochemical phenotype of vagal afferent nerves and/or the neural pathways that they innervate occur in a wide variety of pulmonary diseases, and as such, understanding the mechanisms of vagal sensory function and dysfunction may reveal novel therapeutic targets. In this comprehensive review we discuss historical and state-of-the-art concepts in airway sensory neurobiology and explore mechanisms underlying how vagal sensory pathways become dysfunctional in pathological conditions.
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Cites
The Integrative Action of the Nervous System.
Sherrington, C. (1907) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-190734120-00021 · Cited by 4,136
Neuronal plasticity: Increasing the gain in pain
Woolf, C. J., & Salter, M. W. (2000) · Science · doi:10.1126/science.288.5472.1765 · Cited by 3,781 · cited 1×
“This is further facilitated by a rise in intracellular calcium (due to the release of calcium from internal stores) and the activation of calcium-dependent protein kinases which then phosphorylate the NMDA receptor channel and facilitate glutamate-evoked channel conductance (457).”
BackgroundEvidence for a viscerotopic sensory representation in the cortex and thalamus in the rat
Cechetto, D. F., & Saper, C. B. (1987) · Journal of Comparative Neurology · doi:10.1002/cne.902620104 · Cited by 703 · cited 2×
“Older studies showed that vagal stimulation (not specific for the airways) leads to neuronal activity in the pontine parabrachial nuclei, ventral posteromedial and ventral posterolateral parvocellular nuclei of the thalamus, insula cortex, primary sensory cortex, and amygdala (69, 159, 180, 264), indicative of the exi…”
BackgroundCentral pathways of pulmonary and lower airway vagal afferents.
Kubin, L., Alheid, G. F., Zuperku, E. J., & McCrimmon, D. R. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00252.2006 · Cited by 477
An overview of the anatomy and physiology of slowly adapting pulmonary stretch receptors.
Schelegle, E. S., & Green, J. F. (2001) · Respiration Physiology · doi:10.1016/s0034-5687(00)00202-4 · Cited by 191
Heterogeneity of Nicotinic Cholinergic Receptors in Rat Superior Cervical and Nodose Ganglia
Mao, D., Yasuda, R. P., Fan, H., Wolfe, B. B., & Kellar, K. J. (2006) · Molecular Pharmacology · doi:10.1124/mol.106.027458 · Cited by 81
Axonal projections of pulmonary slowly adapting receptor relay neurons in the rat.
Ezure, K., Tanaka, I., Saito, Y., & Otake, K. (2002) · Journal of Comparative Neurology · doi:10.1002/cne.10185 · Cited by 76
Cited by
Molecular and functional neuroscience in immunity
Pavlov, V. A., Chavan, S. S., & Tracey, K. J. (2018) · Annual Review of Immunology · doi:10.1146/annurev-immunol-042617-053158 · Cited by 444
Desmedt, O., Luminet, O., Maurage, P., & Corneille, O. (2025) · Perspectives on Psychological Science · doi:10.1177/17456916231191537 · Cited by 80
Edwards, M. R., Saglani, S., Schwarze, J., Skevaki, C., Smith, J. A., Ainsworth, B., Almond, M., Andreakos, E., Belvisi, M. G., Chung, K. F., et al. (2017) · European Respiratory Journal · doi:10.1183/13993003.02448-2016 · Cited by 55
Neuroimmune mechanisms of type 2 inflammation in the skin and lung
Tamari, M., & Ver Heul, A. M. (2025) · Allergology International · doi:10.1016/j.alit.2025.02.001 · Cited by 17
Metadata
- Authors
- Mazzone, S. B., & Undem, B. J.
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 2016-07
- Volume
- 96
- Issue
- 3
- Pages
- 975-1024
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- OpenAlex
- W2418994609
- Cited by
- 552
- References
- 7
- FWCI
- 7.92
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
