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Cited by 210Neurotransmitter Receptor Influence on BehaviorStress Responses and CortisolNeuroscience and Neuropharmacology Research

The DOI matches its Crossref record; 52 of the 53 references it cites were found in a registry or an index.

The dopaminergic hyper-responsiveness of the shell of the nucleus accumbens is hormone-dependent

Barrot, Michel, Marinelli, Michela, Abrous, Djoher Nora, Rougé‐Pont, Françoise, Le Moal, Michel, Piazza, Pier Vincenzo·2000·European Journal of Neuroscience
DOI 10.1046/j.1460-9568.2000.00996.x
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Abstract

The dopaminergic projection to the shell of the nucleus accumbens is the most reactive to stress, reward and drugs of abuse and this subregion of the nucleus accumbens is also considered a target of therapeutic effects of atypical antipsychotic drugs (APD). In this report we show, by means of in vivo microdialysis and Fos immunohistochemistry, that the hyper-responsiveness which characterizes the dopaminergic transmission to the shell is dependent on glucocorticoid hormones. In Sprague-Dawley rats, after suppression of endogenous glucocorticoids by adrenalectomy, extracellular dopamine levels selectively decreased in the shell, whilst they remained unchanged in the core. This effect was observed in basal conditions, after a mild stress (vehicle injection), as well as after subcutaneous administration of morphine (2 mg/kg, s.c. ) or intraperitoneal injection of cocaine (15 mg/kg, i.p.). The decrease in dopamine observed in the shell had a postsynaptic impact, as shown by less induction of Fos-like proteins selectively in the shell in response to cocaine. However, the induction of Fos-like proteins by the full D1 agonist SKF82958 (1.5 mg/kg, i.p.) remained unchanged after adrenalectomy, suggesting that the changes in Fos expression after cocaine injection were likely to depend on changes in extracellular dopamine levels rather than on changes in postsynaptic sensitivity to dopamine. The effects of adrenalectomy were glucocorticoid-specific given that they were prevented by corticosterone treatment. This anatomical specificity in the control of neuronal activity by a hormonal input highlights the role of steroid hormones in shaping the functional activity of the brain.

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Research works printed but not linked: 2

  1. Alheid G.F., 1995, The Rat Nervous System, 495
  2. Pellegrino L.J., 1979, A Stereotaxic Atlas of the Brain.

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Metadata

Authors
Barrot, M., Marinelli, M., Abrous, D. N., Rougé‐Pont, F., Le Moal, M., & Piazza, P. V.
Affiliations
Inserm (FR)
Corresponding author
Piazza, Pier Vincenzo
ORCID
Venue
European Journal of Neuroscience
Publisher
Wiley
Published
2000-03
Volume
12
Issue
3
Pages
973-979
ISSN
  • 0953-816X (ISSN-L)
  • 1460-9568
DOI
10.1046/j.1460-9568.2000.00996.x
OpenAlex
W1967379165
Cited by
210
References
53
Citations by year
2026: 1 · 2025: 1 · 2024: 3 · 2023: 4 · 2022: 5 · 2021: 1 · 2020: 4 · 2019: 8 · 2018: 7 · 2017: 16 · 2016: 9 · 2015: 7 · 2014: 10 · 2013: 10 · 2012: 8
FWCI
3.51
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 663 d)
Locations
  • European Journal of Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
nucleus accumbens shell, dopamine signaling, glucocorticoids, adrenalectomy, extracellular dopamine, Fos expression, cocaine, morphine, stress, dopamine D1 receptor, corticosterone, atypical antipsychotics
MeSH terms
Adrenalectomy, Animals, Benzazepines, Cocaine, Corticosterone, Dopamine, Glucocorticoids, Immunohistochemistry, Male, Synaptic Transmission, Nucleus Accumbens, Proto-Oncogene Proteins c-fos, Rats, Sprague-Dawley, Receptors, Dopamine D1, Microdialysis, Dopamine Agonists, Dopamine Uptake Inhibitors, Rats

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