The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Involvement of Nurr1 in specifying the neurotransmitter identity of ventral midbrain dopaminergic neurons
Abstract
The mesencephalic dopaminergic (mesDA) system is involved in many brain functions including motor control and motivated behaviour, and is of clinical importance because of its implication in psychiatric disorders and Parkinson's disease. Nurr1, a member of the nuclear hormone receptor superfamily of transcription factors, is essential for establishing the dopaminergic phenotype, because expression of tyrosine hydroxylase (TH), the rate‐limiting enzyme in dopamine synthesis, requires Nurr1. In addition, Nurr1 plays an important role in the maintenance of mesDA neurons. Neonatal Nurr1 knockout mice lack expression of the dopamine transporter (DAT), the vesicular monoamine transporter 2 (VMAT2) and l‐aromatic amino acid decarboxylase (AADC) in addition to TH specifically in mesDA neurons. It is unclear whether the lack of expression of these dopaminergic markers is caused by a maintenance defect or whether the induction of these markers depends on Nurr1 expression. To address this problem, the expression of DAT, VMAT2 and AADC was analysed at embryonic day 12.5 and 14.5. Here we demonstrate that induction of VMAT2 and DAT specifically in mesDA neurons requires Nurr1 expression, whereas AADC expression in mesDA neurons is induced independently of Nurr1 function.
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“RA-containing nanoparticles increased expression of Nurr1 and Pitx3, key regulators of dopaminergic neuronal development and maintenance68,88.”
From Advances and challenges in retinoid delivery systems in regenerative and therapeutic medicine (2020) · cites this paper as [88]
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The NR4A Subgroup: Immediate Early Response Genes with Pleiotropic Physiological Roles
Maxwell, M., & Muscat, G. E. O. (2006) · Nuclear Receptor Signaling · doi:10.1621/nrs.04002 · Cited by 447
How to make a mesodiencephalic dopaminergic neuron
Smidt, M. P., & Burbach, J. P. H. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn2039 · Cited by 356
“These studies have shown that the neurotransmitter phenotype is partly determined by the transcription factor NURR1 , which regulates several proteins that are required for dopamine synthesis and regulation, such as tyrosine hydroxylase (TH), vesicular monoamine transporter 2 (VMAT2), dopamine transporter (DAT) and RE…”
BackgroundSelf-citationThe role of Nurr1 in the development of dopaminergic neurons and Parkinson's disease
Jankovic, J., Chen, S., & Le, W. D. (2005) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2005.09.001 · Cited by 325
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“MesDA neurons in Nurr1 knockout mice do not express Th, Dat (Slc6a3– Mouse Genome Informatics) and Vmat2(Slc18a2– Mouse Genome Informatics) (Smits et al., 2003) and are lost after initial generation (Zetterström et al.”
BackgroundSelf-citationHow to make a midbrain dopaminergic neuron
Arenas, E., Denham, M., & Villaescusa, C. (2015) · Development · doi:10.1242/dev.097394 · Cited by 321
Metadata
- Authors
- Smits, S. M., Ponnio, T., Conneely, O. M., Burbach, J. P. H., & Smidt, M. P.
- Affiliations
- University Medical Center Utrecht (NL)
- Baylor College of Medicine (US)
- Venue
- European Journal of Neuroscience
- Publisher
- Wiley
- Published
- 2003-10
- Volume
- 18
- Issue
- 7
- Pages
- 1731-1738
- ISSN
- 0953-816X (ISSN-L)
- 1460-9568
- OpenAlex
- W1978387829
- Cited by
- 194
- References
- 47
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 2 · 2023: 4 · 2022: 4 · 2021: 6 · 2020: 11 · 2019: 7 · 2018: 5 · 2017: 11 · 2016: 3 · 2015: 6 · 2014: 7 · 2013: 13 · 2012: 16
- FWCI
- 3.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- Nurr1, midbrain dopaminergic neurons, ventral midbrain, neurotransmitter identity, vesicular monoamine transporter 2, dopamine transporter, tyrosine hydroxylase, transcriptional regulation, embryonic development
- MeSH terms
- Animals, Animals, Newborn, Aromatic-L-Amino-Acid Decarboxylases, DNA-Binding Proteins, Dopamine, Immunohistochemistry, Membrane Glycoproteins, Mesencephalon, Mice, Inbred C57BL, Neurons, Neuropeptides, RNA, Messenger, Transcription Factors, Tyrosine 3-Monooxygenase, In Situ Hybridization, Mice, Knockout, Neurotransmitter Agents, Homeodomain Proteins, Reverse Transcriptase Polymerase Chain Reaction, Membrane Transport Proteins, Vesicular Biogenic Amine Transport Proteins, Vesicular Monoamine Transport Proteins, Mice, Nuclear Receptor Subfamily 4, Group A, Member 2
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