Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter
Abstract
Disruption of the mouse dopamine transporter gene results in spontaneous hyperlocomotion despite major adaptive changes, such as decreases in neurotransmitter and receptor levels. In homozygote mice, dopamine persists at least 100 times longer in the extracellular space, explaining the biochemical basis of the hyperdopaminergic phenotype and demonstrating the critical role of the transporter in regulating neurotransmission. The dopamine transporter is an obligatory target of cocaine and amphetamine, as these psychostimulants have no effect on locomotor activity or dopamine release and uptake in mice lacking the transporter.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Mice lacking the DAT gene display markedly increased levels of DA in the mesolimbic system and striatum, resulting in hyperlocomoter behaviors and deficits in PPI.
“Mice lacking the DAT gene display markedly increased levels of DA in the mesolimbic system and striatum [373], that results in hyperlocomoter behaviors [373,374] and also deficits in PPI [375,376].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [373]
DAT knockout mice show an overall increased level of DA transmission, resulting in increased DA tone, hypermotoric activity, and overall increased movement.
“DAT knockout mice show an overall increased level of DA transmission, resulting in increased DA tone, hypermotoric activity, and overall increased movement [373].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [373]
Cites
Di Chiara, G., & Imperato, A. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.14.5274 · Cited by 4,733 · see citing works
Cocaine Receptors on Dopamine Transporters Are Related to Self-Administration of Cocaine
Ritz, M. C., Lamb, R. J., Goldberg, S. R., & Kuhar, M. J. (1987) · Science · doi:10.1126/science.2820058 · Cited by 2,180 · see citing works
Cellular and molecular mechanisms of drug dependence
Koob, G. F., & Bloom, F. E. (1988) · Science · doi:10.1126/science.2903550 · Cited by 2,070 · see citing works
Ehringer, H., & Hornykiewicz, O. (1960) · Journal of Molecular Medicine · doi:10.1007/bf01485901 · Cited by 1,875 · see citing works
Kelly, P. H., Seviour, P. W., & Iversen, S. D. (1975) · Brain Research · doi:10.1016/0006-8993(75)90233-4 · Cited by 1,740 · see citing works
The neostriatal mosaic: multiple levels of compartmental organization
Gerfen, C. R. (1992) · Trends in Neurosciences · doi:10.1016/0166-2236(92)90355-c · Cited by 1,471 · see citing works
Neurotransmitter Transporters: Recent Progress
Amara, S., & Kuhar, M. J. (1993) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.16.030193.000445 · Cited by 1,088 · see citing works
Role of Transmitter Uptake Mechanisms in Synaptic Neurotransmission
Iversen, L. L. (1971) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1971.tb07066.x · Cited by 776 · see citing works
Sulzer, D., Chen, T., Lau, Y., Kristensen, H., Rayport, S., & Ewing, A. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-05-04102.1995 · Cited by 688 · see citing works
Parkinsonian-like locomotor impairment in mice lacking dopamine D2 receptors
Baik, J., Picetti, R., Saiardi, A., Thiriet, G., Dierich, A., Depaulis, A., LeMeur, M., & Borrelli, E. (1995) · Nature · doi:10.1038/377424a0 · Cited by 651 · see citing works
The dopamine transporter: immunochemical characterization and localization in brain
Ciliax, B. J., Heilman, C. J., Demchyshyn, L. L., Pristupa, Z. B., Ince, E., Hersch, S. M., Niznik, H. B., & Levey, A. I. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-03-01714.1995 · Cited by 589 · see citing works
Molecular characterization of the dopamine transporter.
Giros, B., & Caron, M. (1993) · TIPS - Trends in Pharmacological Sciences · doi:10.1016/0165-6147(93)90029-j · Cited by 582 · see citing works
Self-citationPositive and Negative Schizophrenic Symptoms and the Role of Dopamine
Crow, T. J. (1980) · The British Journal of Psychiatry · doi:10.1192/s0007125000071919 · Cited by 563 · see citing works
Xu, M., Moratalla, R., Gold, L. H., Hiroi, N., Koob, G. F., Graybiel, A. M., & Tonegawa, S. (1994) · Cell · doi:10.1016/0092-8674(94)90557-6 · Cited by 484 · see citing works
Phenotypical characterization of the rat striatal neurons expressing the D1 dopamine receptor gene.
Moine, C. L., Normand, E., & Bloch, B. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.10.4205 · Cited by 472 · see citing works
Dopamine receptor gene expression by enkephalin neurons in rat forebrain.
Moine, C. L., Normand, E., Guitteny, A. F., Fouqué, B., Teoule, R., & Bloch, B. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.1.230 · Cited by 470 · see citing works
Zhou, Q., Quaife, C. J., & Palmiter, R. D. (1995) · Nature · doi:10.1038/374640a0 · Cited by 445 · see citing works
Chemical release of dopamine from striatal homogenates: evidence for an exchange diffusion model.
Fischer, J. F., & Cho, A. K. (1979) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)31549-1 · Cited by 443 · see citing works
Kitayama, S., Shimada, S., Xu, H., Markham, L., Donovan, D. M., & Uhl, G. R. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.16.7782 · Cited by 396 · see citing works
Principles of voltammetry and microelectrode surface states
Kawagoe, K. T., Zimmerman, J. B., & Wightman, R. M. (1993) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(93)90094-8 · Cited by 395 · see citing works
Self-citationRaiteri, M., Cerrito, F., Cervoni, A. M., & Levi, G. (1979) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)31548-x · Cited by 383 · see citing works
Cloning and functional characterization of a cocaine‐sensitive dopamine transporter
Bruno Giros, A., Mestikawy, S. E., Bertrand, L., & Caron, M. G. (1991) · FEBS Letters · doi:10.1016/0014-5793(91)81406-x · Cited by 368 · see citing works
Self-citationAltered striatal function in a mutant mouse lacking D1A dopamine receptors.
Drago, J., Gerfen, C. R., Lachowicz, J. E., Steiner, H., Hollon, T. R., Love, P. E., Ooi, G. T., Grinberg, A., Lee, E. J. K., & Huang, S.-P. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.26.12564 · Cited by 343 · see citing works
Control of dopamine extracellular concentration in rat striatum by impulse flow and uptake
Wightman, R. M., & Zimmerman, J. B. (1990) · Brain Research Reviews · doi:10.1016/0165-0173(90)90015-g · Cited by 328 · see citing works
Self-citationBruno Giros, A., Wang, Y. M., Suter, S. E., McLeskey, S. B., Pifl, C., & Caron, M. G. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)33961-3 · Cited by 322 · see citing works
Self-citationBuck, K. J., & Amara, S. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.26.12584 · Cited by 243 · see citing works
Dopamine uptake: A review of progress in the last decade
Horn, A. S. (1990) · Progress in Neurobiology · doi:10.1016/0301-0082(90)90033-d · Cited by 230 · see citing works
Koller, B. H., & Smithies, O. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.22.8932 · Cited by 216 · see citing works
Fluoxetine, a selective inhibitor of serotonin uptake
Fuller, R. W., Wong, D. T., & Robertson, D. W. (1991) · Medicinal Research Reviews · doi:10.1002/med.2610110103 · Cited by 197 · see citing works
Jones, S. R., Garris, P. A., Kilts, C. D., & Wightman, R. M. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.64062581.x · Cited by 184 · see citing works
Self-citationPifl, C., Giros, B., & Caron, M. G. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-10-04246.1993 · Cited by 175 · see citing works
Self-citationDynamic Observation of Dopamine Autoreceptor Effects in Rat Striatal Slices
Kennedy, R. T., Jones, S. R., & Wightman, R. M. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb09391.x · Cited by 166 · see citing works
Self-citationParker, E. M., & Cubeddu, L. X. (1986) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)24956-4 · Cited by 132 · see citing works
Dopamine transporter mRNA expression is intense in rat midbrain neurons and modest outside midbrain
Cerruti, C., Walther, D. M., Kuhar, M. J., & Uhl, G. R. (1993) · Molecular Brain Research · doi:10.1016/0169-328x(93)90187-t · Cited by 119 · see citing works
Jaber, M., Cador, M., Dumartin, B., Normand, E., Stinus, L., & Bloch, B. (1995) · Neuroscience · doi:10.1016/0306-4522(94)00537-f · Cited by 108 · see citing works
Self-citationMolecular, Functional and Biochemical Characteristics of the Dopamine Transporter
Hitri, A., Hurd, Y. L., Wyatt, R. J., & Deutsch, S. I. (1994) · Clinical Neuropharmacology · doi:10.1097/00002826-199402000-00001 · Cited by 94 · see citing works
Jacocks, H. M., & Cox, B. M. (1992) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)10759-3 · Cited by 84 · see citing works
Dopamine Transporter mRNA in Neurons of the Rat Hypothalamus
Meister, B., & Elde, R. (2008) · Neuroendocrinology · doi:10.1159/000126568 · Cited by 57 · see citing works
The effects of cocaine on maternal behaviors in the rat
Zimmerberg, B., & Gray, M. S. (1992) · Physiology & Behavior · doi:10.1016/0031-9384(92)90287-c · Cited by 49 · see citing works
Baumann, M. H., & Rothman, R. B. (1993) · Brain Research · doi:10.1016/0006-8993(93)90792-l · Cited by 24 · see citing works
Tison, F., Normand, E., & Bloch, B. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90837-0 · Cited by 16 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Dauer, W., & Przedborski, S. (2003) · Neuron · doi:10.1016/s0896-6273(03)00568-3 · Cited by 5,469 · see citing works
Predictive reward signal of dopamine neurons
Schultz, W. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.80.1.1 · Cited by 4,564 · see citing works
Dopamine receptors: from structure to function
MISSALE, C., NASH, S. R., ROBINSON, S. W., JABER, M., & CARON, M. G. (1998) · Physiological Reviews · doi:10.1152/physrev.1998.78.1.189 · Cited by 3,633 · see citing works
Self-citationThe physiology, signaling, and pharmacology of dopamine receptors
Beaulieu, J.-M., & Gainetdinov, R. R. (2011) · Pharmacological Reviews · doi:10.1124/pr.110.002642 · Cited by 2,763 · see citing works
Fredholm, B. B., Bättig, K., Holmén, J., Nehlig, A., & Zvartau, E. E. (1999) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01396-6 · Cited by 2,624 · see citing works
Getting formal with dopamine and reward
Schultz, W. (2002) · Neuron · doi:10.1016/s0896-6273(02)00967-4 · Cited by 2,574 · see citing works
Prolactin: structure, function, and regulation of secretion
Freeman, M. E., Kanyicska, B., Lerant, A., & Nagy, G. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.4.1523 · Cited by 2,457 · see citing works
Molecular genetics of attention-deficit/hyperactivity disorder
Faraone, S. V., Perlis, R. H., Doyle, A. E., Smoller, J. W., Goralnick, J. J., Holmgren, M. A., & Sklar, P. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.11.024 · Cited by 2,357 · see citing works
The Endocannabinoid System as an Emerging Target of Pharmacotherapy
Pacher, P., Bátkai, S., & Kunos, G. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.3.2 · Cited by 2,077 · see citing works
Neuroscience of attention-deficit/hyperactivity disorder: the search for endophenotypes
Castellanos, F. X., & Tannock, R. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn896 · Cited by 1,827 · see citing works
Geyer, M. A., Krebs-Thomson, K., Braff, D. L., & Swerdlow, N. R. (2001) · Psychopharmacology · doi:10.1007/s002130100811 · Cited by 1,484 · see citing works
Genetics of attention deficit hyperactivity disorder
Faraone, S. V., & Larsson, H. (2019) · Molecular Psychiatry · doi:10.1038/s41380-018-0070-0 · Cited by 1,338 · see citing works
Dopamine and the regulation of cognition and attention
Nieoullon, A. (2002) · Progress in Neurobiology · doi:10.1016/s0301-0082(02)00011-4 · Cited by 1,131 · see citing works
Mice with Reduced NMDA Receptor Expression Display Behaviors Related to Schizophrenia
Mohn, A. R., Gainetdinov, R. R., Caron, M. G., & Koller, B. H. (1999) · Cell · doi:10.1016/s0092-8674(00)81972-8 · Cited by 1,075 · see citing works
Self-citationDopamine: Functions, Signaling, and Association with Neurological Diseases
Klein, M. O., Battagello, D. S., Cardoso, A. R., Hauser, D. N., Bittencourt, J. C., & Correa, R. G. (2019) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-018-0632-3 · Cited by 1,073 · see citing works
Koob, G. F., Sanna, P. P., & Bloom, F. E. (1998) · Neuron · doi:10.1016/s0896-6273(00)80557-7 · Cited by 1,026 · see citing works
Candidate gene studies of ADHD: a meta-analytic review
Gizer, I. R., Ficks, C., & Waldman, I. D. (2009) · Human Genetics · doi:10.1007/s00439-009-0694-x · Cited by 1,020 · see citing works
Addiction: A Disease of Learning and Memory
Hyman, S. E. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.8.1414 · Cited by 980 · see citing works
Dopamine as a Prolactin (PRL) Inhibitor
Ben-Jonathan, N., & Hnasko, R. (2001) · Endocrine Reviews · doi:10.1210/edrv.22.6.0451 · Cited by 983 · see citing works
Volkow, N. D., Chang, L., Wang, G.-J., Fowler, J. S., Ding, Y.-S., Sedler, M., Logan, J., Franceschi, D., Gatley, J., Hitzemann, R., et al. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.12.2015 · Cited by 916 · see citing works
Gogos, J. A., Morgan, M., Luine, V., Santha, M., Ogawa, S., Pfaff, D., & Karayiorgou, M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.17.9991 · Cited by 864 · see citing works
Neurobiology of attention-deficit hyperactivity disorder
Faraone, S. V., & Biederman, J. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00240-6 · Cited by 811 · see citing works
Overlapping neuronal circuits in addiction and obesity: evidence of systems pathology
Volkow, N. D., Wang, G.-J., Fowler, J. S., & Telang, F. (2008) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2008.0107 · Cited by 809 · see citing works
Volkow, N. D., Wang, G.-J., Fowler, J. S., Logan, J., Gerasimov, M., Maynard, L., Ding, Y.-S., Gatley, S. J., Gifford, A., & Franceschi, D. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-02-j0001.2001 · Cited by 770 · see citing works
Volk, D. W., Austin, M. C., Pierri, J. N., Sampson, A. R., & Lewis, D. A. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.3.237 · Cited by 697 · see citing works
Morón, J. A., Brockington, A., Wise, R. A., Rocha, B. A., & Hope, B. T. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-02-00389.2002 · Cited by 681 · see citing works
Reward deficiency syndrome: genetic aspects of behavioral disorders
Comings, D. E., & Blum, K. (2000) · Progress in Brain Research · doi:10.1016/s0079-6123(00)26022-6 · Cited by 621 · see citing works
Molecular and cellular aspects of nicotine abuse
Dani, J. A., & Heinemann, S. (1996) · Neuron · doi:10.1016/s0896-6273(00)80112-9 · Cited by 605 · see citing works
Prefrontal cortical regulation of brainwide circuit dynamics and reward-related behavior
Ferenczi, E. A., Zalocusky, K. A., Liston, C., Grosenick, L., Warden, M. R., Amatya, D., Katovich, K., Mehta, H., Patenaude, B., Ramakrishnan, C., et al. (2016) · Science · doi:10.1126/science.aac9698 · Cited by 535 · see citing works
Hyperdopaminergic mutant mice have higher "wanting" but not "liking" for sweet rewards
Peciña, S., Cagniard, B., Berridge, K. C., Aldridge, J. W., & Zhuang, X. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-28-09395.2003 · Cited by 551 · see citing works
Catecholaminergic systems in stress: structural and molecular genetic approaches
Kvetnansky, R., Sabban, E. L., & Palkovits, M. (2009) · Physiological Reviews · doi:10.1152/physrev.00042.2006 · Cited by 548 · see citing works
Sagvolden, T. (2000) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(99)00058-5 · Cited by 525 · see citing works
Conditional calcineurin knockout mice exhibit multiple abnormal behaviors related to schizophrenia
Miyakawa, T., Leiter, L. M., Gerber, D. J., Gainetdinov, R. R., Sotnikova, T. D., Zeng, H., Caron, M. G., & Tonegawa, S. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1432926100 · Cited by 489 · see citing works
Self-citationWaldman, I. D., Rowe, D. C., Abramowitz, A., Kozel, S. T., Mohr, J. H., Sherman, S. L., Cleveland, H. H., Sanders, M. L., Gard, J. M. C., & Stever, C. (1998) · The American Journal of Human Genetics · doi:10.1086/302132 · Cited by 462 · see citing works
Are we dependent upon coffee and caffeine? A review on human and animal data
Nehlig, A. (1999) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(98)00050-5 · Cited by 453 · see citing works
Volkow, N. D., Wang, G., Fowler, J. S., Logan, J., Jayne, M., Franceschi, D., Wong, C., Gatley, S. J., Gifford, A. N., Ding, Y., et al. (2002) · Synapse · doi:10.1002/syn.10075 · Cited by 452 · see citing works
Molecular Genetics of Attention Deficit Hyperactivity Disorder
Faraone, S. V., & Mick, E. (2010) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2009.12.004 · Cited by 411 · see citing works
“Treating these ‘‘knockout’’ mice with stimulants reduces their hyperactivity.(52,53) Using a family-based association study, Cook and colleagues(54) first reported an association between ADHD and the 10-repeat allele of the 30UTR VNTR.”
BackgroundStriatal dopamine neurotransmission: Regulation of release and uptake
Sulzer, D., Cragg, S. J., & Rice, M. E. (2016) · Basal Ganglia · doi:10.1016/j.baga.2016.02.001 · Cited by 382 · see citing works
Spencer, T., Biederman, J., Wilens, T., Doyle, R., Surman, C., Prince, J., Mick, E., Aleardi, M., Herzig, K., & Faraone, S. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.11.043 · Cited by 385 · see citing works
Bello, E. P., Mateo, Y., Gelman, D. M., Noaín, D., Shin, J. H., Low, M. J., Alvarez, V. A., Lovinger, D. M., & Rubinstein, M. (2011) · Nature Neuroscience · doi:10.1038/nn.2862 · Cited by 364 · see citing works
Lewis, D. A., Melchitzky, D. S., Sesack, S. R., Whitehead, R. E., Auh, S., & Sampson, A. (2001) · Journal of Comparative Neurology · doi:10.1002/cne.1092 · Cited by 352 · see citing works
Prickaerts, J., Moechars, D., Cryns, K., Lenaerts, I., van Craenendonck, H., Goris, I., Daneels, G., Bouwknecht, J. A., & Steckler, T. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.5216-05.2006 · Cited by 341 · see citing works
Mill, J., Asherson, P., Browes, C., D'Souza, U., & Craig, I. (2002) · American Journal of Medical Genetics · doi:10.1002/ajmg.b.10948 · Cited by 341 · see citing works
Dopamine: a key regulator to adapt action, emotion, motivation and cognition
Nieoullon, A., & Coquerel, A. (2003) · Current Opinion in Neurology · doi:10.1097/00019052-200312002-00002 · Cited by 315 · see citing works
Dichter, G. S., Damiano, C. A., & Allen, J. A. (2012) · Journal of Neurodevelopmental Disorders · doi:10.1186/1866-1955-4-19 · Cited by 299 · see citing works
Neurobehavioral evidence for changes in dopamine system activity during adolescence
Wahlstrom, D., White, T., & Luciana, M. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.12.007 · Cited by 277 · see citing works
Volkow, N. D., Wang, G.-J., Fowler, J. S., Telang, F., Maynard, L., Logan, J., Gatley, S. J., Pappas, N., Wong, C., Vaska, P., et al. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.7.1173 · Cited by 281 · see citing works
Porrino, L. J., Lyons, D., Smith, H. R., Daunais, J. B., & Nader, M. A. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.5578-03.2004 · Cited by 276 · see citing works
Ralph, R. J., Paulus, M. P., Fumagalli, F., Caron, M. G., & Geyer, M. A. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-01-00305.2001 · Cited by 271 · see citing works
Self-citationHeinz, A. (2002) · European Psychiatry · doi:10.1016/s0924-9338(02)00628-4 · Cited by 270 · see citing works
Feeding behavior in dopamine-deficient mice
Szczypka, M. S., Rainey, M. A., Kim, D. S., Alaynick, W. A., Marck, B. T., Matsumoto, A. M., & Palmiter, R. D. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.21.12138 · Cited by 242 · see citing works
Letchworth, S. R., Nader, M. A., Smith, H. R., Friedman, D. P., & Porrino, L. J. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-08-02799.2001 · Cited by 239 · see citing works
Jucaite, A., Fernell, E., Halldin, C., Forssberg, H., & Farde, L. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.11.009 · Cited by 236 · see citing works
Stuber, G. D., Roitman, M. F., Phillips, P. E. M., Carelli, R. M., & Wightman, R. M. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300619 · Cited by 217 · see citing works
Self-citationPrepulse inhibition and genetic mouse models of schizophrenia
Powell, S. B., Zhou, X., & Geyer, M. A. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.04.021 · Cited by 218 · see citing works
Cui, C., Booker, T. K., Allen, R. S., Grady, S. R., Whiteaker, P., Marks, M. J., Salminen, O., Tritto, T., Butt, C. M., Allen, W. R., et al. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-35-11045.2003 · Cited by 213 · see citing works
Parallel maturation of goal-directed behavior and dopaminergic systems during adolescence
Naneix, F., Marchand, A. R., Di Scala, G., Pape, J.-R., & Coutureau, E. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.3080-12.2012 · Cited by 209 · see citing works
Stimulus-dependent dopamine release in attention-deficit/hyperactivity disorder.
Sikström, S., & Söderlund, G. (2007) · Psychological Review · doi:10.1037/0033-295x.114.4.1047 · Cited by 205 · see citing works
Anterior pituitary hypoplasia and dwarfism in mice lacking the dopamine transporter
Bossé, R., Fumagalli, F., Jaber, M., Giros, B., Gainetdinov, R. R., Wetsel, W. C., Missale, C., & Caron, M. G. (1997) · Neuron · doi:10.1016/s0896-6273(00)80353-0 · Cited by 203 · see citing works
Self-citationSmits, S. M., Ponnio, T., Conneely, O. M., Burbach, J. P. H., & Smidt, M. P. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02885.x · Cited by 194 · see citing works
López-Gil, X., Babot, Z., Amargós-Bosch, M., Suñol, C., Artigas, F., & Adell, A. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301356 · Cited by 183 · see citing works
Role of Tumor Necrosis Factor-α in Methamphetamine-Induced Drug Dependence and Neurotoxicity
Nakajima, A., Yamada, K., Nagai, T., Uchiyama, T., Miyamoto, Y., Mamiya, T., He, J., Nitta, A., Mizuno, M., Tran, M. H., et al. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.4847-03.2004 · Cited by 176 · see citing works
A highly tunable dopaminergic oscillator generates ultradian rhythms of behavioral arousal
Blum, I. D., Zhu, L., Moquin, L., Kokoeva, M. V., Gratton, A., Giros, B., & Storch, K.-F. (2014) · eLife · doi:10.7554/elife.05105 · Cited by 168 · see citing works
Self-citationGenetics of adult attention-deficit/hyperactivity disorder
Faraone, S. V. (2004) · Psychiatric Clinics of North America · doi:10.1016/s0193-953x(03)00090-x · Cited by 166 · see citing works
Monoamine-sensitive developmental periods impacting adult emotional and cognitive behaviors
Suri, D., Teixeira, C. M., Cagliostro, M. K. C., Mahadevia, D., & Ansorge, M. S. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2014.231 · Cited by 167 · see citing works
Evidence of increased dopamine receptor signaling in food-restricted rats
Carr, K. D., Tsimberg, Y., Berman, Y., & Yamamoto, N. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00227-6 · Cited by 167 · see citing works
Walitza, S., Renner, T. J., Dempfle, A., Konrad, K., Wewetzer, C., Halbach, A., Herpertz-Dahlmann, B., Remschmidt, H., Smidt, J., Linder, M., et al. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001734 · Cited by 158 · see citing works
Zhu, J., & Reith, M. (2008) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152708786927877 · Cited by 140 · see citing works
Brodski, C., Weisenhorn, D. M. V., Signore, M., Sillaber, I., Oesterheld, M., Broccoli, V., Acampora, D., Simeone, A., & Wurst, W. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-10-04199.2003 · Cited by 131 · see citing works
Viral Gene Delivery Selectively Restores Feeding and Prevents Lethality of Dopamine-Deficient Mice
Szczypka, M. S., Mandel, R. J., Donahue, B. A., Snyder, R. O., Leff, S. E., & Palmiter, R. D. (1999) · Neuron · doi:10.1016/s0896-6273(00)80688-1 · Cited by 129 · see citing works
Drenan, R. M., Grady, S. R., Steele, A. D., McKinney, S., Patzlaff, N. E., McIntosh, J. M., Marks, M. J., Miwa, J. M., & Lester, H. A. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.2056-10.2010 · Cited by 127 · see citing works
Ziegler, S., Pedersen, M. L., Mowinckel, A. M., & Biele, G. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.09.002 · Cited by 110 · see citing works
Cragg, S. J., Rice, M. E., & Greenfield, S. A. (1997) · Journal of Neurophysiology · doi:10.1152/jn.1997.77.2.863 · Cited by 118 · see citing works
Characterization of A11 neurons projecting to the spinal cord of mice
Koblinger, K., Füzesi, T., Ejdrygiewicz, J., Krajacic, A., Bains, J. S., & Whelan, P. J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0109636 · Cited by 114 · see citing works
Trinh, J. V., Nehrenberg, D. L., Jacobsen, J. P. R., Caron, M. G., & Wetsel, W. C. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00165-9 · Cited by 113 · see citing works
Self-citationBarr, A. M., Lehmann-Masten, V., Paulus, M., Gainetdinov, R. R., Caron, M. G., & Geyer, M. A. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300343 · Cited by 103 · see citing works
Self-citationMesolimbic dopamine super-sensitivity in melanin-concentrating hormone-1 receptor-deficient mice
Smith, D. G., Tzavara, E. T., Shaw, J., Luecke, S., Wade, M., Davis, R., Salhoff, C., Nomikos, G. G., & Gehlert, D. R. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.4079-04.2005 · Cited by 103 · see citing works
Altered midbrain dopaminergic neurotransmission during development in an animal model of ADHD
Leo, D., Sorrentino, E., Volpicelli, F., Eyman, M., Greco, D., Viggiano, D., di Porzio, U., & Perrone-Capano, C. (2003) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2003.08.009 · Cited by 103 · see citing works
Cellular and subcellular localization of the dopamine transporter in rat cortex
Sesack, S. R., Hawrylak, V. A., Guido, M. A., & Levey, A. I. (1997) · Advances in pharmacology · doi:10.1016/s1054-3589(08)60720-6 · Cited by 101 · see citing works
Vazquez, V., Penit-Soria, J., Durand, C., Besson, M. J., Giros, B., & Daugé, V. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.4807-04.2005 · Cited by 101 · see citing works
Self-citationNeurosteroid Actions in Memory and Neurologic/Neuropsychiatric Disorders
Ratner, M. H., Kumaresan, V., & Farb, D. H. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00169 · Cited by 96 · see citing works
Kollins, S. H., & Adcock, R. A. (2014) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2014.02.002 · Cited by 95 · see citing works
Phasic dopamine signals: from subjective reward value to formal economic utility
Schultz, W., Carelli, R. M., & Wightman, R. M. (2015) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2015.09.006 · Cited by 88 · see citing works
Review: Genetics of Attention Deficit/Hyperactivity Disorder
Wallis, D., Russell, H. F., & Muenke, M. (2008) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/jsn049 · Cited by 86 · see citing works
Amsterdam, J. D., & Newberg, A. B. (2007) · Neuropsychobiology · doi:10.1159/000106476 · Cited by 84 · see citing works
Abnormal neurodevelopment, neurosignaling and behaviour in Npas3-deficient mice
Brunskill, E. W., Ehrman, L. A., Williams, M. T., Klanke, J., Hammer, D., Schaefer, T. L., Sah, R., Il, G. W. D., Potter, S. S., & Vorhees, C. V. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04291.x · Cited by 84 · see citing works
The current status of association studies in obsessive-compulsive disorder
Hemmings, S. M. J., & Stein, D. J. (2006) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2006.02.011 · Cited by 83 · see citing works
Salvatore, M. F., Calipari, E. S., & Jones, S. R. (2016) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.6b00064 · Cited by 72 · see citing works
Self-citationEarly Adolescence is a Critical Period for the Maturation of Inhibitory Behavior
Reynolds, L. M., Yetnikoff, L., Pokinko, M., Wodzinski, M., Epelbaum, J. G., Lambert, L. C., Cossette, M.-P., Arvanitogiannis, A., & Flores, C. (2019) · Cerebral Cortex · doi:10.1093/cercor/bhy247 · Cited by 75 · see citing works
Drug addiction: from bench to bedside
Cheron, J., & Kerchove d’Exaerde, A. D. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01542-0 · Cited by 75 · see citing works
Brown, E. S., Nejtek, V. A., Perantie, D. C., Rajan Thomas, N., & Rush, A. J. (2003) · Journal of Clinical Psychopharmacology · doi:10.1097/01.jcp.0000085412.08426.08 · Cited by 67 · see citing works
Kambeitz, J., Romanos, M., & Ettinger, U. (2014) · The Pharmacogenomics Journal · doi:10.1038/tpj.2013.9 · Cited by 64 · see citing works
Chang, T. T., Yeh, T. L., Chiu, N. T., Chen, P. S., Huang, H. Y., Yang, Y. K., Lee, I. H., & Lu, R. B. (2010) · Bipolar Disorders · doi:10.1111/j.1399-5618.2009.00771.x · Cited by 63 · see citing works
Powell, S. B., Young, J. W., Ong, J. C., Caron, M. G., & Geyer, M. A. (2008) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e32830dc110 · Cited by 57 · see citing works
Self-citationHIRONAKA, N., IKEDA, K., SORA, I., UHL, G. R., & NIKI, H. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1316.018 · Cited by 55 · see citing works
An international multicenter association study of the serotonin transporter gene in persistent ADHD
Landaas, E. T., Johansson, S., Jacobsen, K. K., Ribasés, M., Bosch, R., Sánchez‐Mora, C., Jacob, C. P., Boreatti‐Hümmer, A., Kreiker, S., Lesch, K. ‐., et al. (2010) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2010.00567.x · Cited by 55 · see citing works
Yacubian, J., & Büchel, C. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.05.015 · Cited by 53 · see citing works
Holst, S. C., Müller, T., Valomon, A., Seebauer, B., Berger, W., & Landolt, H.-P. (2017) · Scientific Reports · doi:10.1038/srep45982 · Cited by 45 · see citing works
Mice lacking adenylyl cyclase‐5 cope badly with repeated restraint stress
Kim, K., & Han, P. (2009) · Journal of Neuroscience Research · doi:10.1002/jnr.22119 · Cited by 42 · see citing works
DIETZ, D., TAPOCIK, J., GAVALCRUZ, M., & KABBAJ, M. (2005) · Physiology & Behavior · doi:10.1016/j.physbeh.2005.08.005 · Cited by 41 · see citing works
- Authors
- Giros, B., Jaber, M., Jones, S. R., Wightman, R. M., & Caron, M. G.
- Affiliations
- Howard Hughes Medical Institute (US)
- University of North Carolina at Chapel Hill (US)
- Venue
- Nature
- Published
- 1996-02
- Volume
- 379
- Issue
- 6566
- Pages
- 606-612
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2014793858
- Cited by
- 2,476
- References
- 41
- Citations by year
- 2026: 34 · 2025: 39 · 2024: 32 · 2023: 61 · 2022: 52 · 2021: 62 · 2020: 47 · 2019: 54 · 2018: 62 · 2017: 67 · 2016: 58 · 2015: 74 · 2014: 93 · 2013: 73 · 2012: 97
- FWCI
- 43.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Keywords
- dopamine transporter, hyperlocomotion, cocaine, amphetamine, psychostimulants, dopamine, neurotransmitter levels, locomotor activity, dopamine release, dopamine uptake
- MeSH terms
- Amphetamine, Animals, Carrier Proteins, Cell Line, Cocaine, Dopamine, Dynorphins, Enkephalins, Female, Gene Expression Regulation, Locomotion, Male, Membrane Glycoproteins, Mice, Inbred C57BL, Nerve Tissue Proteins, Protein Precursors, Mice, Knockout, Gene Targeting, Membrane Transport Proteins, Dopamine Plasma Membrane Transport Proteins, Mice, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review