Cited by 2,476Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchParkinson's Disease Mechanisms and Treatments

Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter

Giros, Bruno, Jaber, Mohamed, Jones, Sara R., Wightman, R. Mark, Caron, Marc G.·1996·Nature

Abstract

Disruption of the mouse dopamine transporter gene results in spontaneous hyperlocomotion despite major adaptive changes, such as decreases in neurotransmitter and receptor levels. In homozygote mice, dopamine persists at least 100 times longer in the extracellular space, explaining the biochemical basis of the hyperdopaminergic phenotype and demonstrating the critical role of the transporter in regulating neurotransmission. The dopamine transporter is an obligatory target of cocaine and amphetamine, as these psychostimulants have no effect on locomotor activity or dopamine release and uptake in mice lacking the transporter.

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Crossref · 10.1038/379606a0

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Authors
Giros, B., Jaber, M., Jones, S. R., Wightman, R. M., & Caron, M. G.
Affiliations
  • Howard Hughes Medical Institute (US)
  • University of North Carolina at Chapel Hill (US)
Venue
Nature
Published
1996-02
Volume
379
Issue
6566
Pages
606-612
ISSN
  • 0028-0836 (ISSN-L)
  • 1476-4687
OpenAlex
W2014793858
Cited by
2,476
References
41
Citations by year
2026: 34 · 2025: 39 · 2024: 32 · 2023: 61 · 2022: 52 · 2021: 62 · 2020: 47 · 2019: 54 · 2018: 62 · 2017: 67 · 2016: 58 · 2015: 74 · 2014: 93 · 2013: 73 · 2012: 97
FWCI
43.87
Type
journal article
Language
en
Open access
closed
Locations
  • Nature (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
Keywords
dopamine transporter, hyperlocomotion, cocaine, amphetamine, psychostimulants, dopamine, neurotransmitter levels, locomotor activity, dopamine release, dopamine uptake
MeSH terms
Amphetamine, Animals, Carrier Proteins, Cell Line, Cocaine, Dopamine, Dynorphins, Enkephalins, Female, Gene Expression Regulation, Locomotion, Male, Membrane Glycoproteins, Mice, Inbred C57BL, Nerve Tissue Proteins, Protein Precursors, Mice, Knockout, Gene Targeting, Membrane Transport Proteins, Dopamine Plasma Membrane Transport Proteins, Mice, Rats

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