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Gestational diabetes mellitus in the last trimester – a feature of maternal iron excess?
Abstract
SUMMARY Aim To determine whether non‐anaemic women with gestational diabetes mellitus (GDM) diagnosed in third trimester pregnancy have evidence of increased iron stores compared with matched non‐diabetic controls. Methods In a prospective study, women who had antenatal booking before 20 weeks' gestation and without anaemia or diabetes mellitus were recruited at the time of the oral glucose tolerance test (OGTT) at 28–31 weeks' gestation for the study of serum ferritin, iron and transferrin concentrations. The results were blinded to the managing obstetricians. After delivery, the records were reviewed. The cases diagnosed as GDM were compared with a control group (two controls for each index case matched for parity) selected at random from the at‐risk but nondiabetic cases. Results GDM was diagnosed in 97 of the 401 women recruited. Compared with the 194 controls, there was no difference in the weight, body mass index, booking and third trimester haemoglobin, or third trimester red cell indices, but concentrations of serum ferritin, iron, transferrin saturation, and the post‐natal haemoglobin were significantly higher. On multiple regression analysis, maternal BMI and the log‐transformed ferritin concentration remained significant determinants of the OGTT 2‐h glucose value. Conclusion The results suggest an association between increased iron stores and glucose intolerance at the third trimester in non‐anaemic women. The role of iron excess in the pathogenesis of GDM needs to be examined.
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“Iron 'excess' is also a known feature of gestational diabetes [591-593], and is a clear risk factor for the disease even in 'normal' populations [594-603], and indeed diabetes is a classical consequence of iron overloading as seen in hereditary haemochromatosis [604].”
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Cross-Talk Between Iron Metabolism and Diabetes
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“diabetes [591-593], and is a clear risk factor for the”
BackgroundSerum Ferritin and Risk of the Metabolic Syndrome in U.S. Adults
Jehn, M., Clark, J. M., & Guallar, E. (2004) · Diabetes Care · doi:10.2337/diacare.27.10.2422 · Cited by 443
“Second, serum ferritin levels correlated with various measures of insulin sensitivity in several different populations, including individuals without diabetes (6,21), individuals with diabetes (22), women with gestational diabetes (23), and patients with thalassemia (24).”
BackgroundRole of Minerals and Trace Elements in Diabetes and Insulin Resistance
Dubey, P., Thakur, V., & Chattopadhyay, M. (2020) · Nutrients · doi:10.3390/nu12061864 · Cited by 407
“The results revealed no change in the weight, BMI, or hemoglobin levels in the third trimester, but showed significantly higher concentrations of serum ferritin, iron, transferrin saturation and postnatal hemoglobin, suggesting a correlation between increased iron stores and glucose intolerance [82].”
Background
Metadata
- Authors
- Lao, T. T., Chan, P. L., & Tam, K. F.
- Affiliations
- Tsan Yuk Hospital (CN)
- Corresponding author
- Lao, T. T.
- Venue
- Diabetic Medicine
- Publisher
- Wiley
- Published
- 2001-03
- Volume
- 18
- Issue
- 3
- Pages
- 218-223
- ISSN
- 0742-3071 (ISSN-L)
- 1464-5491
- OpenAlex
- W1988582933
- Cited by
- 137
- References
- 35
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 4 · 2023: 6 · 2022: 7 · 2021: 7 · 2020: 7 · 2019: 4 · 2018: 5 · 2017: 4 · 2016: 11 · 2015: 5 · 2014: 11 · 2013: 9 · 2012: 7
- FWCI
- 6.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetic Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Keywords
- gestational diabetes mellitus, iron overload, iron stores, serum ferritin, transferrin saturation, third trimester, impaired glucose tolerance, body mass index
- MeSH terms
- Adult, Birth Weight, Cross-Sectional Studies, Female, Ferritins, Gestational Age, Glucose Tolerance Test, Hemoglobins, Humans, Infant, Newborn, Iron, Maternal Age, Pregnancy, Pregnancy Trimester, Third, Reference Values, Transferrin, Diabetes, Gestational, Dietary Supplements
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