Body Iron Stores Are Associated With Serum Insulin and Blood Glucose Concentrations: Population study in 1,013 eastern Finnish men
Abstract
OBJECTIVE: To study if there is an association between mildly elevated body iron and glucose homeostasis indexes. RESEARCH DESIGN AND METHODS: A cross-sectional population study was conducted in 1,013 middle-aged men, and an association of serum ferritin with concentrations of serum insulin, blood glucose, and serum fructosamine was tested. RESULTS: The mean concentration of fasting serum insulin was 21.6% higher (95% CI 7.3–37.9%, P < 0.001) in the 5th quintile of serum ferritin compared with the 1st quintile. The elevation in blood glucose was 6.1% (95% CI 2.3–9.9%, P < 0.001) and in serum fructosamine 3.9% (1.5–6.9%, P < 0.01). CONCLUSIONS: Mildly elevated body iron stores are associated with statistically significant elevations in glucose homeostasis indexes.
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Iron excess is a known feature of gestational diabetes and a clear risk factor for diabetes even in normal populations; diabetes is a classical consequence of iron overloading in hereditary haemochromatosis.
“Iron 'excess' is also a known feature of gestational diabetes [591-593], and is a clear risk factor for the disease even in 'normal' populations [594-603], and indeed diabetes is a classical consequence of iron overloading as seen in hereditary haemochromatosis [604].”
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- Authors
- Tuomainen, T.-P., Nyyssönen, K., Salonen, R., Tervahauta, A., Korpela, H., Lakka, T., Kaplan, G. A., & Salonen, J. T.
- Affiliations
- Research Institute of Public Health, University of Kuopio Kuopio, Finland
- Department of Community Health and General Practice, University of Kuopio Kuopio, Finland
- Department of Health Services (US)
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 1997-03-01
- Volume
- 20
- Issue
- 3
- Pages
- 426-428
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- OpenAlex
- W2131210225
- Cited by
- 312
- References
- 0
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 9 · 2023: 11 · 2022: 5 · 2021: 8 · 2020: 9 · 2019: 5 · 2018: 9 · 2017: 14 · 2016: 12 · 2015: 16 · 2014: 19 · 2013: 23 · 2012: 12
- FWCI
- 3.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes Care (publishedVersion)
- PubMed (publishedVersion)
- Deep Blue (University of Michigan) (submittedVersion)
- Funders
- World Health Organization
- Academy of Finland
- National Heart, Lung, and Blood Institute (HL-44199, R01HL044199)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- iron stores, serum ferritin, serum insulin, blood glucose, glucose homeostasis, fructosamine, iron overload, middle-aged men, diabetes risk
- MeSH terms
- Adult, Blood Glucose, Cross-Sectional Studies, Diabetes Mellitus, Fasting, Ferritins, Finland, Follow-Up Studies, Glucose Tolerance Test, Homeostasis, Humans, Insulin, Male, Middle Aged, Cohort Studies, Fructosamine
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