The prevalence of the mitochondrial DNA 16189 variant in non‐diabetic Korean adults and its association with higher fasting glucose and body mass index
Abstract
Aims To evaluate the prevalence of the 16189 variant of mitochondrial DNA in Korean adults and its association with insulin resistance. Methods We investigated 160 non‐diabetic subjects from a community‐based diabetes survey conducted in Yonchon County, Korea in 1993. We extracted the DNA from peripheral blood and examined the 16189 variant by polymerase chain reaction and restrictive enzyme digestion. We compared body mass index (BMI), blood pressure, fasting plasma glucose, 2‐h plasma glucose after 75 g glucose load, fasting insulin, cholesterol, and homeostasis model assessment of insulin resistance and β‐cell function between the subjects with 16189 variant and wild type. Results The prevalence of the 16189 variant in Korean adults was 28.8% (46 of 160). Subjects with the 16189 variant had higher fasting glucose and BMI than those with wild type, but fasting insulin, homeostasis model assessment of insulin resistance and β‐cell function, cholesterol, and blood pressure were not different between two groups. Conclusion Our results provide evidence for an association of a frequent mitochondrial polymorphism with higher fasting glucose and the risk factors of diabetes mellitus.
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In European and Asian groups, the 16189T>C variant in the mtDNA D-loop is linked to obesity and type 2 diabetes.
“Analysis of both European126 and Asian populations127 showed that the 16189T>C substitution in the D-loop region of mtDNA is associated with obesity and T2DM.”
From Mitochondrial and metabolic dysfunction in ageing and age-related diseases (2022) · cites this paper as [127]
Variations in mtDNA have been linked to higher risk for metabolic disorders.
“Interestingly, mtDNA polymorphisms have been associated with an increased risk of metabolic diseases.”
From Mitochondrial and metabolic dysfunction in ageing and age-related diseases (2022) · cites this paper as [127]
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Mitochondrial and metabolic dysfunction in ageing and age-related diseases
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- Authors
- Kim, J. H., Park, K. S., Cho, Y. M., Kang, B. S., Kim, S. K., Jeon, H. J., Kim, S. Y., & Lee, H. K.
- Affiliations
- Seoul National University (KR)
- Seoul National University Hospital (KR)
- Corresponding author
- Cho, Y. M.
- Lee, H. K.
- Venue
- Diabetic Medicine
- Publisher
- Wiley
- Published
- 2002-07-30
- Volume
- 19
- Issue
- 8
- Pages
- 681-684
- ISSN
- 0742-3071 (ISSN-L)
- 1464-5491
- OpenAlex
- W2037030851
- Cited by
- 52
- References
- 19
- Citations by year
- 2025: 1 · 2024: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2018: 1 · 2017: 2 · 2016: 1 · 2015: 2 · 2014: 1 · 2013: 3 · 2012: 4
- FWCI
- 2.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetic Medicine (publishedVersion)
- PubMed (publishedVersion)
- Seoul National University Open Repository (Seoul National University) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- mitochondrial DNA, mitochondrial polymorphism, insulin resistance, fasting blood glucose, body mass index, diabetes risk factors, HOMA-IR, beta-cell function, Korean adults, prevalence
- MeSH terms
- Adult, Aged, Aged, 80 and over, Blood Glucose, Blood Pressure, DNA, Mitochondrial, Female, Homeostasis, Humans, Insulin Resistance, Islets of Langerhans, Korea, Male, Middle Aged, Polymorphism, Genetic, Regression Analysis, Body Mass Index
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