The DOI matches its Crossref record; 32 of the 33 references it cites were found in a registry or an index.
Heart rate variability in patients with untreated Parkinson's disease
Abstract
The aim of this study was to evaluate cardiovascular responses as a marker of autonomic nervous system (ANS) disturbances in patients with untreated Parkinson's disease (PD) and to assess the relationship between them and the clinical characteristics of PD. The ANS functions were investigated in 50 patients with PD and 55 healthy subjects by measuring standard cardiovascular autonomic reflexes and heart rate variability (HRV) at rest using spectral analysis (the autoregressive model and the fast Fourier transformation), the percentage of the counts of beat-to-beat variation greater than 50 ms and the fractal dimension. Significantly attenuated HRV and deficient blood pressure reaction to tilting were found in the PD patient group. The patients with hypokinesia/rigidity as the initial symptom of PD had a more pronounced HRV deficit than those with tremor onset. Untreated PD patients suffer significant failure in cardiovascular nervous system regulation, and in patients with hypokinesia/rigidity as their initial disease manifestation the risk of this ANS dysfunction is high. However, in the early stages of PD these changes did not reach significance at individual level.
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In the citing paper
“Similar to motor function, prominent changes in 24-hour rhythms of heart rate and blood pressure have been repeatedly reported in PD.”
From Circadian dysregulation in Parkinson's disease (2017) · cites this paper as Kallio et al., 2000
In the citing paper
“These studies report reversal of the normal diurnal rhythm of BP with increased diurnal variability of BP and elevations of overnight BP along with loss of diurnal HR variability and a disappearance of the sympathetic morning peak (Haapaniemi et al., 2001, Kallio et al., 2000, Kallio et al., 2004, Mastrocola et al., 1999).”
From Circadian dysregulation in Parkinson's disease (2017) · cites this paper as Kallio et al., 2000
Citations
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'The clocks that time us'—circadian rhythms in neurodegenerative disorders
Videnović, A., Lázár, A. S., Barker, R. A., & Overeem, S. (2014) · Nature Reviews Neurology · doi:10.1038/nrneurol.2014.206 · Cited by 381
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Metadata
- Authors
- Kallio, M., Haapaniemi, T., Turkka, J., Suominen, K., Tolonen, U., Sotaniemi, K., Heikkilä, V. ‐., & Myllylä, V.
- Affiliations
- University of Oulu (FI)
- Corresponding author
- Kallio, M.
- ORCID
- Kallio, M.
- Venue
- European Journal of Neurology
- Publisher
- Wiley
- Published
- 2000-12
- Volume
- 7
- Issue
- 6
- Pages
- 667-672
- ISSN
- 1351-5101 (ISSN-L)
- 1468-1331
- OpenAlex
- W2007990975
- Cited by
- 115
- References
- 33
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 2 · 2022: 4 · 2021: 5 · 2020: 3 · 2019: 5 · 2018: 3 · 2017: 4 · 2016: 12 · 2015: 8 · 2014: 13 · 2013: 7 · 2012: 7
- FWCI
- 1.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Syncope and Autonomic Disorders
- Keywords
- Parkinson's disease, heart rate variability, autonomic dysfunction, untreated Parkinson's disease, fractal dimension, beat-to-beat variation
- MeSH terms
- Adult, Aged, Autonomic Nervous System, Blood Pressure, Female, Heart Rate, Humans, Male, Middle Aged, Parkinson Disease, Reference Values, Valsalva Maneuver, Tilt-Table Test
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