Cited by 115Heart Rate Variability and Autonomic ControlParkinson's Disease Mechanisms and TreatmentsCardiovascular Syncope and Autonomic Disorders

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Heart rate variability in patients with untreated Parkinson's disease

Kallio, M., Haapaniemi, T., Turkka, J., Suominen, K., Tolonen, U., Sotaniemi, K., Heikkilä, V.‐P., Myllylä, V.·2000·European Journal of Neurology

DOI 10.1046/j.1468-1331.2000.00127.x

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Abstract

The aim of this study was to evaluate cardiovascular responses as a marker of autonomic nervous system (ANS) disturbances in patients with untreated Parkinson's disease (PD) and to assess the relationship between them and the clinical characteristics of PD. The ANS functions were investigated in 50 patients with PD and 55 healthy subjects by measuring standard cardiovascular autonomic reflexes and heart rate variability (HRV) at rest using spectral analysis (the autoregressive model and the fast Fourier transformation), the percentage of the counts of beat-to-beat variation greater than 50 ms and the fractal dimension. Significantly attenuated HRV and deficient blood pressure reaction to tilting were found in the PD patient group. The patients with hypokinesia/rigidity as the initial symptom of PD had a more pronounced HRV deficit than those with tremor onset. Untreated PD patients suffer significant failure in cardiovascular nervous system regulation, and in patients with hypokinesia/rigidity as their initial disease manifestation the risk of this ANS dysfunction is high. However, in the early stages of PD these changes did not reach significance at individual level.

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Authors: Kallio, M., Haapaniemi, T., Turkka, J., Suominen, K., Tolonen, U., Sotaniemi, K., Heikkilä, V. ‐., & Myllylä, V.
Affiliations: University of Oulu (FI)
Corresponding author: Kallio, M.
ORCID: Kallio, M.
Venue: European Journal of Neurology
Publisher: Wiley
Published: 2000-12
Volume: 7
Issue: 6
Pages: 667-672
ISSN: 1351-5101 (ISSN-L)
1468-1331
DOI: 10.1046/j.1468-1331.2000.00127.x
OpenAlex: W2007990975
Cited by: 115
References: 33
Citations by year: 2026: 5 · 2025: 8 · 2024: 2 · 2022: 4 · 2021: 5 · 2020: 3 · 2019: 5 · 2018: 3 · 2017: 4 · 2016: 12 · 2015: 8 · 2014: 13 · 2013: 7 · 2012: 7
FWCI: 1.48
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 399 d)
Locations: European Journal of Neurology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Syncope and Autonomic Disorders
Keywords: Parkinson's disease, heart rate variability, autonomic dysfunction, untreated Parkinson's disease, fractal dimension, beat-to-beat variation
MeSH terms: Adult, Aged, Autonomic Nervous System, Blood Pressure, Female, Heart Rate, Humans, Male, Middle Aged, Parkinson Disease, Reference Values, Valsalva Maneuver, Tilt-Table Test

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Heart rate variability in patients with untreated Parkinson's disease

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