The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Topiramate in the Treatment of Chronic Migraine
Open accessAbstract
The purpose of this study was to evaluate the efficacy of topiramate in the treatment of chronic migraine. This was a double-blind, randomized, placebo controlled, parallel-group study. Patients suffering from chronic migraine with analgesic overuse were randomly assigned in a 1 : 1 ratio to receive topiramate or placebo. Following a baseline phase of eight weeks, the study drug was titrated in 25-mg increments over one week to 50 mg daily. Titration phase was followed by a 8-week maintenance phase. Number of days with headache during a 28-day period was the efficacy variable. At baseline, there was no difference in the number of days with headache between patients treated with topiramate and those treated with placebo (mean ± SD: 20.9 ± 3.2 and 20.8 ± 3.2, respectively). During the last 4 week-maintenance phase, topiramate-treated patients experienced a significantly lower 28-day headache frequency in comparison to those treated with placebo (mean number of days with headache ± SD: 8.1 ± 8.1 vs. 20.6 ± 3.4, P < 0.0007). Topiramate at low doses proved to be an effective therapeutic approach to reduce headache frequency in patients with chronic migraine and analgesic overuse.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“significant issues persist in patients who do not benefit from current drug treatments [54, 55]”
From Protocol and methods for testing the efficacy of well-being therapy in chronic migraine patients: a randomized controlled trial. (2018) · cites this paper as [54]
Citations
Cites
Sorge, F., Simone, R. D., Marano, E., Nolano, M., Orefice, G., & Carrieri, P. B. (1988) · Cephalalgia · doi:10.1046/j.1468-2982.1988.0801001.x · Cited by 3,464
Bonica, J. J., Melzack, R., & Wall, P. D. (1999) · Cited by 2,537
Periaqueductal Gray Matter Dysfunction in Migraine: Cause or the Burden of Illness?
Welch, K. M. A., Nagesh, V., Aurora, S. K., & Gelman, N. (2001) · Headache The Journal of Head and Face Pain · doi:10.1046/j.1526-4610.2001.041007629.x · Cited by 621
Classification of daily and near-daily headaches
Silberstein, S. D., Lipton, R. B., & Sliwinski, M. J. (1996) · Neurology · doi:10.1212/wnl.47.4.871 · Cited by 613
White, H. S., Brown, S. D., Woodhead, J. H., Skeen, G. A., & Wolf, H. H. (1997) · Epilepsy Research · doi:10.1016/s0920-1211(97)00045-4 · Cited by 356
Lipton, R. B., Stewart, W. F., Sawyer, J. P. C., & Edmeads, J. G. (2001) · Headache The Journal of Head and Face Pain · doi:10.1111/j.1526-4610.2001.01156.x · Cited by 340
The Midbrain Periaqueductal Gray Matter
Depaulis, A., & Bandler, R. J. (1991) · Springer eBooks · doi:10.1007/978-1-4615-3302-3 · Cited by 317
The Midbrain periaqueductal gray matter : functional, anatomical, and neurochemical organization
Depaulis, A., & Bandler, R. J. (1991) · Plenum Press eBooks · Cited by 216
Topiramate in Migraine Prevention: A Double‐Blind, Placebo‐Controlled Study
Storey, J. R., Calder, C., Hart, D. E., & Potter, D. (2001) · Headache The Journal of Head and Face Pain · doi:10.1046/j.1526-4610.2001.01190.x · Cited by 196
Topiramate: a review of preclinical, pharmacokinetic, and clinical data
Rosenfeld, W. E. (1997) · Clinical Therapeutics · doi:10.1016/s0149-2918(97)80006-9 · Cited by 186
Quality of life in chronic daily headache
Guitera, V., Muñoz, P., Castillo, J., & Pascual, J. (2002) · Neurology · doi:10.1212/wnl.58.7.1062 · Cited by 160
MRI of the occipital cortex, red nucleus, and substantia nigra during visual aura of migraine
Welch, K. M. A., Cao, Y., Aurora, S. K., Wiggins, G. C., & Vikingstad, E. M. (1998) · Neurology · doi:10.1212/wnl.51.5.1465 · Cited by 129
Topiramate-treated cluster headache
Wheeler, S. D., & Carrazana, E. J. (1999) · Neurology · doi:10.1212/wnl.53.1.234 · Cited by 124
Topiramate increases cerebral GABA in healthy humans
Kuzniecky, R., Hetherington, H. P., Ho, S., Pan, J. W., Martin, R. C., Gilliam, F. G., Hugg, J. W., & Faught, E. (1998) · Neurology · doi:10.1212/wnl.51.2.627 · Cited by 112
Long-Term Follow-Up of Patients Treated for Chronic Headache with Analgesic Overuse
Pini, L.-A., Cicero, A., & Sandrini, M. (2001) · Cephalalgia · doi:10.1046/j.1468-2982.2001.00288.x · Cited by 95
Chronic daily headache: nosology and pathophysiology
Welch, M. K. A., & Goadsby, P. J. (2002) · Current Opinion in Neurology · doi:10.1097/00019052-200206000-00011 · Cited by 86
Divalproex in the Long‐term Treatment of Chronic Daily Headache
Freitag, F. G., Diamond, S., Diamond, M. L., & Urban, G. J. (2001) · Headache The Journal of Head and Face Pain · doi:10.1046/j.1526-4610.2001.111006271.x · Cited by 62
Headaches Associated With Chronic Use of Analgesics: A Therapeutic Approach
Pini, L. A., Bigarelli, M., Vitale, G., & Sternieri, E. (1996) · Headache The Journal of Head and Face Pain · doi:10.1046/j.1526-4610.1996.3607433.x · Cited by 60
Topiramate: A Case Series Study in Migraine Prophylaxis
Young, W., Hopkins, M., Shechter, A. L., & Silberstein, S. (2002) · Cephalalgia · doi:10.1046/j.1468-2982.2002.00380.x · Cited by 58
Treatment of Cluster Headache with Topiramate: Effects and Side-Effects in Five Patients
Förderreuther, S., Mayer, M. F., & Straube, A. M. (2002) · Cephalalgia · doi:10.1046/j.1468-2982.2002.00339.x · Cited by 56
Guitera, V., Muñoz, P., Castillo, J., & Pascual, J. (1999) · Cephalalgia · doi:10.1046/j.1468-2982.1999.1910847.x · Cited by 27
Cellular Adaptation in Migraineurs with Chronic Daily Headache
Hering, R., Gardiner, I., Catarci, T., Whitmarsh, T. E., Steiner, T. J., & de Belleroche, J. (1993) · Cephalalgia · doi:10.1046/j.1468-2982.1993.1304261.x · Cited by 24
Management of Chronic Daily Headache Utilizing a Uniform Treatment Pathway
Rothrock, J. F. (1999) · Headache The Journal of Head and Face Pain · doi:10.1046/j.1526-4610.1999.3909650.x · Cited by 19
Research works printed but not linked: 4
- Headache Classification Committee of the International Headache Society., 1988, Cephalalgia, 8, 1
- Edwards KR, 2000, Neurology, 54, A81
- Krusz JC, 1999, Headache, 39, 363
- Storey JR, 1999, Neurology, 52, A211
Cited by
Sorted by citations
Aurora, S. K., Dodick, D., Turkel, C., DeGryse, R., Silberstein, S., Lipton, R. B., Diener, H., & Brin, M. F. (2010) · Cephalalgia · doi:10.1177/0333102410364676 · Cited by 1,056
Diener, H., Dodick, D., Aurora, S. K., Turkel, C., DeGryse, R., Lipton, R. B., Silberstein, S., & Brin, M. F. (2010) · Cephalalgia · doi:10.1177/0333102410364677 · Cited by 974
Chronic migraine: risk factors, mechanisms and treatment
May, A., & Schulte, L. H. (2016) · Nature Reviews Neurology · doi:10.1038/nrneurol.2016.93 · Cited by 634
Diener, H., Bussone, G., Oene, J. V., Lahaye, M., Schwalen, S., & Goadsby, P. (2007) · Cephalalgia · doi:10.1111/j.1468-2982.2007.01326.x · Cited by 561
Silberstein, S. D., Lipton, R. B., Dodick, D. W., Freitag, F. G., Ramadan, N. M., Mathew, N. T., Brandes, J. L., BIGAL, M. E., Saper, J. R., Ascher, S., et al. (2007) · Headache The Journal of Head and Face Pain · doi:10.1111/j.1526-4610.2006.00684.x · Cited by 495
Metadata
- Authors
- Silvestrini, M., Bartolini, M., Coccia, M., Baruffaldi, R., Taffi, R., & Provinciali, L.
- Affiliations
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Department of Neurological Sciences, University of Ancona, Ancona, Italy
- Corresponding author
- Silvestrini, M
- Venue
- Cephalalgia
- Publisher
- SAGE Publications
- Published
- 2003-10
- Volume
- 23
- Issue
- 8
- Pages
- 820-824
- ISSN
- 0333-1024 (ISSN-L)
- 1468-2982
- OpenAlex
- W2015197538
- Cited by
- 162
- References
- 23
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 6 · 2020: 3 · 2019: 3 · 2018: 4 · 2017: 4 · 2016: 5 · 2015: 9 · 2014: 9 · 2013: 7 · 2012: 9
- FWCI
- 5.04
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cephalalgia (publishedVersion)
- PubMed (publishedVersion)
- Università Politecnica delle Marche (Università Politecnica delle Marche) (submittedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Migraine and Headache Studies
- Health Sciences › Dentistry › Oral Surgery › Temporomandibular Joint Disorders
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Keywords
- topiramate, chronic migraine, analgesic overuse, headache frequency, anticonvulsant prophylaxis, dose titration
- MeSH terms
- Topiramate, Adult, Analgesics, Chronic Disease, Double-Blind Method, Female, Fructose, Humans, Male, Middle Aged, Migraine Disorders, Multivariate Analysis, Confidence Intervals, Chi-Square Distribution, Odds Ratio
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
