Cited by 162Migraine and Headache StudiesTemporomandibular Joint DisordersPain Mechanisms and Treatments

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Topiramate in the Treatment of Chronic Migraine

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Silvestrini, M, Bartolini, M, Coccia, M, Baruffaldi, R, Taffi, R, Provinciali, L·2003·Cephalalgia

DOI 10.1046/j.1468-2982.2003.00592.x

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Abstract

The purpose of this study was to evaluate the efficacy of topiramate in the treatment of chronic migraine. This was a double-blind, randomized, placebo controlled, parallel-group study. Patients suffering from chronic migraine with analgesic overuse were randomly assigned in a 1 : 1 ratio to receive topiramate or placebo. Following a baseline phase of eight weeks, the study drug was titrated in 25-mg increments over one week to 50 mg daily. Titration phase was followed by a 8-week maintenance phase. Number of days with headache during a 28-day period was the efficacy variable. At baseline, there was no difference in the number of days with headache between patients treated with topiramate and those treated with placebo (mean ± SD: 20.9 ± 3.2 and 20.8 ± 3.2, respectively). During the last 4 week-maintenance phase, topiramate-treated patients experienced a significantly lower 28-day headache frequency in comparison to those treated with placebo (mean number of days with headache ± SD: 8.1 ± 8.1 vs. 20.6 ± 3.4, P < 0.0007). Topiramate at low doses proved to be an effective therapeutic approach to reduce headache frequency in patients with chronic migraine and analgesic overuse.

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Authors: Silvestrini, M., Bartolini, M., Coccia, M., Baruffaldi, R., Taffi, R., & Provinciali, L.
Affiliations: Istituti di Ricovero e Cura a Carattere Scientifico (IT)
Department of Neurological Sciences, University of Ancona, Ancona, Italy
Corresponding author: Silvestrini, M
ORCID: Silvestrini, M
Bartolini, M
Venue: Cephalalgia
Publisher: SAGE Publications
Published: 2003-10
Volume: 23
Issue: 8
Pages: 820-824
ISSN: 0333-1024 (ISSN-L)
1468-2982
DOI: 10.1046/j.1468-2982.2003.00592.x
OpenAlex: W2015197538
Cited by: 162
References: 23
Citations by year: 2026: 2 · 2025: 4 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 6 · 2020: 3 · 2019: 3 · 2018: 4 · 2017: 4 · 2016: 5 · 2015: 9 · 2014: 9 · 2013: 7 · 2012: 9
FWCI: 5.04
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Cephalalgia (publishedVersion)
PubMed (publishedVersion)
Università Politecnica delle Marche (Università Politecnica delle Marche) (submittedVersion)
Topics: Health Sciences › Medicine › Clinical Neurology › Migraine and Headache Studies
Health Sciences › Dentistry › Oral Surgery › Temporomandibular Joint Disorders
Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Keywords: topiramate, chronic migraine, analgesic overuse, headache frequency, anticonvulsant prophylaxis, dose titration
MeSH terms: Topiramate, Adult, Analgesics, Chronic Disease, Double-Blind Method, Female, Fructose, Humans, Male, Middle Aged, Migraine Disorders, Multivariate Analysis, Confidence Intervals, Chi-Square Distribution, Odds Ratio

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Topiramate in the Treatment of Chronic Migraine

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