Confocal laser scanning microscopy of porcine skin: implications for human wound healing studies
Abstract
The structure of porcine skin as examined by light microscopy is reviewed and its similarities to and differences from human skin are highlighted. Special imaging techniques and staining procedures are described and their use in gathering morphological information in porcine skin is discussed. Confocal laser scanning microscopy (CLSM) was employed to examine the structure of porcine skin and the findings are presented as an adjunct to the information already available in the literature. It is concluded that CLSM provides valuable additional morphological information to material examined by conventional microscopy and is useful for wound healing studies in the porcine model.
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Domestic pigs represent a relevant animal model with a skin highly similar in its architecture to the human skin.
“domestic pigs representing a relevant animal model with a skin highly similar in its architecture to the human skin [25,26].”
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References 25 · Cited by 177
- Authors
- VARDAXIS, N. J., BRANS, T. A., BOON, M. E., KREIS, R. W., & MARRES, L. M.
- Affiliations
- RMIT University (AU)
- Venue
- Journal of Anatomy
- Publisher
- Wiley
- Published
- 1997-06
- Volume
- 190
- Issue
- 4
- Pages
- 601-611
- ISSN
- 0021-8782 (ISSN-L)
- 1469-7580
- OpenAlex
- W2151607513
- Cited by
- 177
- References
- 25
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 3 · 2023: 6 · 2022: 3 · 2021: 12 · 2020: 4 · 2019: 11 · 2018: 3 · 2017: 10 · 2016: 17 · 2015: 10 · 2014: 14 · 2013: 10 · 2012: 7
- FWCI
- 1.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Anatomy (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Health Sciences › Medicine › Urology › Comparative Animal Anatomy Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Advanced Fluorescence Microscopy Techniques
- Keywords
- porcine skin, skin anatomy, wound healing, porcine model, skin morphology, confocal laser scanning microscopy
- MeSH terms
- Animals, Collagen, Disease Models, Animal, Coloring Agents, Elastin, Epidermis, Female, Macrophages, Mast Cells, Muscle, Smooth, Skin, Swine, Wound Healing, Microscopy, Confocal
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