The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Rapid Communication: Oxidative Stress Induces Apoptosis in Embryonic Cortical Neurons
Abstract
Abstract: Glutamate‐induced glutathione depletion in immature embryonic cortical neurons has been shown to lead to oxidative stress and cell death. We have used this in vitro model to investigate the mechanism(s) by which free radicals induce neuronal degeneration. We find that glutathione depletion leads to hypercondensation and fragmentation of chromatin into spherical or irregular shapes, a morphologic signature of apoptosis. These morphologic changes are accompanied by laddering of DNA into multiple oligonucleosomal fragments and can be prevented by the antioxidants idebenone and butylated hydroxyanisole. Cell death induced by glutathione depletion can also be prevented by inhibitors of macromolecular synthesis. Taken together, these observations suggest that oxidative stress can induce apoptosis in neurons.
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Citations
Cites
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Induction of Apoptosis by the Low-Affinity NGF Receptor
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Cited by
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
Dixon, S. J., Lemberg, K. M., Lamprecht, M. R., Skouta, R., Zaitsev, E. M., Gleason, C. E., Patel, D. N., Bauer, A. J., Cantley, A. M., Yang, W. S., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.042 · Cited by 18,691
Oxidative Stress, Glutamate, and Neurodegenerative Disorders
Coyle, J. T., & Puttfarcken, P. (1993) · Science · doi:10.1126/science.7901908 · Cited by 3,762
Sleiman, S. F., Henry, J., Al-Haddad, R., El Hayek, L., Abou Haidar, E., Stringer, T., Ulja, D., Karuppagounder, S. S., Holson, E. B., Ratan, R. R., et al. (2016) · eLife · doi:10.7554/elife.15092 · Cited by 810
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Metadata
- Authors
- Ratan, R. R., Murphy, T. H., & Baraban, J. M.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 1994-01
- Volume
- 62
- Issue
- 1
- Pages
- 376-379
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W2011371104
- Cited by
- 584
- References
- 20
- FWCI
- 19.85
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Rapid Communication: Oxidative Stress Induces Apoptosis in Embryonic Cortical Neurons. https://app.cochat.ai/papers/10.1046/j.1471-4159.1994.62010376.x
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- Ratan, R. R., Murphy, T. H., & Baraban, J. M. (1994). Rapid Communication: Oxidative Stress Induces Apoptosis in Embryonic Cortical Neurons. Journal of Neurochemistry. https://doi.org/10.1046/j.1471-4159.1994.62010376.x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
