The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
bcl-2 inhibits death of central neural cells induced by multiple agents.
Open accessAbstract
The protooncogene bcl-2, which has been implicated in B-cell lymphoma development, inhibits apoptosis due to growth factor withdrawal in some, but not all, hematopoietic cells. Recently we found that bcl-2 also inhibits apoptosis in PC12 pheochromocytoma cells. We now report that bcl-2 inhibits the death of a central neural cell line due to serum and growth factor withdrawal, the calcium ionophore A23187, glucose withdrawal, membrane peroxidation, and, in some cases, free radical-induced damage. This broad range of protective effects of BCL-2 protein suggests that BCL-2 may interact with a central step in neural cell death. Measurements of intracellular free calcium suggest that BCL-2 alters the transduction of neural death signals at a point distal to the rise in intracellular free calcium.
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Citations
Cites
Cell death and control of cell survival in the oligodendrocyte lineage
Barres, B. A., Hart, I. K., Coles, H. S. R., Burne, J. F., Voyvodic, J. T., Richardson, W. D., & Raff, M. C. (1992) · Cell · doi:10.1016/0092-8674(92)90531-g · Cited by 1,345
Nuñez, G., London, L., Hockenbery, D., Alexander, M., McKearn, J. P., & Korsmeyer, S. J. (1990) · The Journal of Immunology · doi:10.4049/jimmunol.144.9.3602 · Cited by 899
Cited by
Apoptosis in the Pathogenesis and Treatment of Disease
Thompson, C. B. (1995) · Science · doi:10.1126/science.7878464 · Cited by 6,524
Bcl-2 functions in an antioxidant pathway to prevent apoptosis
Hockenbery, D. M., Oltvai, Z. N., Yin, X.-M., Milliman, C. L., & Korsmeyer, S. J. (1993) · Cell · doi:10.1016/0092-8674(93)80066-n · Cited by 3,419
Bcl-2 and the regulation of programmed cell death
Reed, J. (1994) · The Journal of cell biology · doi:10.1083/jcb.124.1.1 · Cited by 2,305
Leist, M., Single, B., Castoldi, A. F., Kühnle, S., & Nicotera, P. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.8.1481 · Cited by 1,871
Massive Cell Death of Immature Hematopoietic Cells and Neurons in Bcl-x-Deficient Mice
Motoyama, N., Wang, F., Roth, K. A., Sawa, H., Nakayama, K.-I., Nakayama, K., Negishi, I., Senju, S., Zhang, Q., Fujii, S., et al. (1995) · Science · doi:10.1126/science.7878471 · Cited by 1,163
Metadata
- Authors
- Zhong, L. T., Sarafian, T., Kane, D. J., Charles, A. C., Mah, S. P., Edwards, R. H., & Bredesen, D. E.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1993-05-15
- Volume
- 90
- Issue
- 10
- Pages
- 4533-4537
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2053640261
- Cited by
- 619
- References
- 2
- FWCI
- 17.36
- Type
- journal article
- Language
- en
- Open access
- green
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- Zhong, L. T., Sarafian, T., Kane, D. J., Charles, A. C., Mah, S. P., Edwards, R. H., & Bredesen, D. E. (1993). bcl-2 inhibits death of central neural cells induced by multiple agents. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.90.10.4533
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