The DOI matches its Crossref record.
Quaternary Structure of the Native GABAA Receptor Determined by Electron Microscopic Image Analysis
Abstract
Abstract: In the transmitter‐gated ion channel class of receptors, the members of which are all believed to be heterooligomers, the number and arrangement of the subunits are only known with any certainty for the nicotinic acetylcholine receptor from Torpedo electric fish. That receptor has been shown to possess a pentameric rosette structure, with five homologous subunits (α 2 βγδ) arranged to enclose the central ion channel. The data were obtained by electron image analysis of two‐dimensional receptor arrays, which form as a consequence of that receptor's exceptionally high abundance in the Torpedo membranes and are therefore not attainable for other receptors. We have applied another direct approach to determine the quaternary structure of native ionotropic GABA receptors. We have purified those receptors from porcine brain cortex and analysed the rotational symmetry of isolated receptors visualized by electron microscopy. The results show the receptor to have a pentameric structure with a central water‐filled pore, which can now be said to be characteristic of the entire superfamily.
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Citations
Cited by
Macdonald, R. L., & Olsen, R. W. (1994) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.17.030194.003033 · Cited by 1,975
Fritschy, J., & Mohler, H. (1995) · Journal of Comparative Neurology · doi:10.1002/cne.903590111 · Cited by 1,244
Hippocampal GABAergic Inhibitory Interneurons
Pelkey, K. A., Chittajallu, R., Craig, M. T., Tricoire, L., Wester, J. C., & McBain, C. J. (2017) · Physiological Reviews · doi:10.1152/physrev.00007.2017 · Cited by 889
Barnard, E. A., Skolnick, P., Olsen, R. W., Mohler, H., Sieghart, W., Biggio, G., Braestrup, C., Bateson, A. N., & Langer, S. Z. (1998) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01363-2 · Cited by 632
Self-citationGABA and GABA Receptors in the Central Nervous System and Other Organs
Watanabe, M., Maemura, K., Kanbara, K., Tamayama, T., & Hayasaki, H. (2002) · International Review of Cytology · doi:10.1016/s0074-7696(02)13011-7 · Cited by 630
Metadata
- Authors
- Nayeem, N., Green, T. P., Martin, I. L., & Barnard, E. A.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 1994-02
- Volume
- 62
- Issue
- 2
- Pages
- 815-818
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W2023468172
- Cited by
- 437
- References
- 0
- FWCI
- 18.83
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Quaternary Structure of the Native GABAA Receptor Determined by Electron Microscopic Image Analysis. https://app.cochat.ai/papers/10.1046/j.1471-4159.1994.62020815.x
- The paper
- Nayeem, N., Green, T. P., Martin, I. L., & Barnard, E. A. (1994). Quaternary Structure of the Native GABAA Receptor Determined by Electron Microscopic Image Analysis. Journal of Neurochemistry. https://doi.org/10.1046/j.1471-4159.1994.62020815.x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
