GABA A ‐receptor heterogeneity in the adult rat brain: Differential regional and cellular distribution of seven major subunits
Abstract
GABAA-receptors display an extensive structural heterogeneity based on the differential assembly of a family of at least 15 subunits (alpha 1-6, beta 1-3, gamma 1-3, delta, rho 1-2) into distinct heteromeric receptor complexes. The subunit composition of receptor subtypes is expected to determine their physiological properties and pharmacological profiles, thereby contributing to flexibility in signal transduction and allosteric modulation. In heterologous expression systems, functional receptors require a combination of alpha-, beta-, and gamma-subunit variants, the gamma 2-subunit being essential to convey a classical benzodiazepine site to the receptor. The subunit composition and stoichiometry of native GABAA-receptor subtypes remain unknown. The aim of this study was to identify immunohistochemically the main subunit combinations expressed in the adult rat brain and to allocate them to identified neurons. The regional and cellular distribution of seven major subunits (alpha 1, alpha 2, alpha 3, alpha 5, beta 2,3, gamma 2, delta) was visualized by immunoperoxidase staining with subunit-specific antibodies (the beta 2- and beta 3-subunits were covisualized with the monoclonal antibody bd-17). Putative receptor subtypes were identified on the basis of colocalization of subunits within individual neurons, as analyzed by confocal laser microscopy in double- and triple-immunofluorescence staining experiments. The results reveal an extraordinary heterogeneity in the distribution of GABAA-receptor subunits, as evidenced by abrupt changes in immunoreactivity along well-defined cytoarchitectonic boundaries and by pronounced differences in the cellular distribution of subunits among various types of neurons. Thus, functionally and morphologically diverse neurons were characterized by a distinct GABAA-receptor subunit repertoire. The multiple staining experiments identified 12 subunit combinations in defined neurons. The most prevalent combination was the triplet alpha 1/beta 2,3/gamma 2, detected in numerous cell types throughout the brain. An additional subunit (alpha 2, alpha 3, or delta) sometimes was associated with this triplet, pointing to the existence of receptors containing four subunits. The triplets alpha 2/beta 2,3/gamma 2, alpha 3/beta 2,3/gamma 2, and alpha 5/beta 2,3/gamma 2 were also identified in discrete cell populations. The prevalence of these seven combinations suggest that they represent major GABAA-receptor subtypes. Five combinations also apparently lacked the beta 2,3-subunits, including one devoid of gamma 2-subunit (alpha 1/alpha 2/gamma 2, alpha 2/gamma 2, alpha 3/gamma 2, alpha 2/alpha 3/gamma 2, alpha 2/alpha 5/delta).(ABSTRACT TRUNCATED AT 400 WORDS)
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
α2GABAARs are densely expressed in the central amygdala.
“α2-GABAARs are densely expressed in the central amygdala [35, 36, 40], but their precise cellular location and function are still unknown.”
From An emerging circuit pharmacology of GABAA receptors (2018) · cites this paper as [35]
α5GABAARs are expressed at negligible levels in the CeA.
“This finding is striking, as α5GABAARs are expressed at negligible levels in the CeA [35, 36]”
From An emerging circuit pharmacology of GABAA receptors (2018) · cites this paper as [35]
Cites
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585 · see citing works
Hsu, S. M., Raine, L., & Fanger, H. (1981) · Journal of Histochemistry & Cytochemistry · doi:10.1177/29.4.6166661 · Cited by 14,248 · see citing works
Ledent, C. A., Valverde, O., Cossu, G., Petitet, F., Aubert, J.-F., Beslot, F., Böhme, G. A., Impérato, A., Pedrazzini, T., Roques, B. P., et al. (1999) · Science · doi:10.1126/science.283.5400.401 · Cited by 3,612 · see citing works
GABA<sub>A</sub> Receptor Channels
Macdonald, R. L., & Olsen, R. W. (1994) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.17.030194.003033 · Cited by 1,975 · see citing works
Sequence and functional expression of the GABAA receptor shows a ligand-gated receptor super-family
Schofield, P. R., Darlison, M. G., Fujita, N., Burt, D. R., Stephenson, F. A., Rodriguez, H., Rhee, L. M., Ramachandran, J., Reale, V., Glencorse, T. A., et al. (1987) · Nature · doi:10.1038/328221a0 · Cited by 1,622 · see citing works
Wisden, W., Laurie, D. J., Monyer, H., & Seeburg, P. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-03-01040.1992 · Cited by 1,543 · see citing works
Importance of a novel GABAA receptor subunit for benzodiazepine pharmacology
Pritchett, D. B., Sontheimer, H. W., Shivers, B. D., Ymer, S., Kettenmann, H., Schofield, P. R., & Seeburg, P. H. (1989) · Nature · doi:10.1038/338582a0 · Cited by 1,293 · see citing works
Majewska, M. D. (1992) · Progress in Neurobiology · doi:10.1016/0301-0082(92)90025-a · Cited by 1,087 · see citing works
Petralia, R. S., & Wenthold, R. J. (1992) · The Journal of Comparative Neurology · doi:10.1002/cne.903180309 · Cited by 999 · see citing works
Petralia, R. S., Yokotani, N., & Wenthold, R. J. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-02-00667.1994 · Cited by 850 · see citing works
Type I and Type II GABA A -Benzodiazepine Receptors Produced in Transfected Cells
Pritchett, D. B., Lüddens, H., & Seeburg, P. H. (1989) · Science · doi:10.1126/science.2551039 · Cited by 718 · see citing works
Laurie, D., Seeburg, P., & Wisden, W. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-03-01063.1992 · Cited by 668 · see citing works
The effect of subunit composition of rat brain GABAA receptors on channel function
Sigel, E., Baur, R., Trube, G., Möhler, H., & Malherbe, P. (1990) · Neuron · doi:10.1016/0896-6273(90)90224-4 · Cited by 595 · see citing works
Somogyi, P., & Takagi, H. (1982) · Neuroscience · doi:10.1016/0306-4522(82)90035-5 · Cited by 572 · see citing works
AMPA glutamate receptor subunits are differentially distributed in rat brain
Martin, L. J., Blackstone, C. D., Levey, A. I., Huganir, R. L., & Price, D. L. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90199-p · Cited by 569 · see citing works
Functional properties of recombinant rat GABAA receptors depend upon subunit composition
Verdoorn, T. A., Draguhn, A., Ymer, S., Seeburg, P. H., & Sakmann, B. J. (1990) · Neuron · doi:10.1016/0896-6273(90)90145-6 · Cited by 553 · see citing works
Cerebellar GABAA receptor selective for a behavioural alcohol antagonist
Lüddens, H., Pritchett, D. B., Köhler, M. G., Killisch, I., KEINÄNEN, K. P., Monyer, H., Sprengel, R., & Seeburg, P. H. (1990) · Nature · doi:10.1038/346648a0 · Cited by 538 · see citing works
Fritschy, J., Paysan, J., Enna, A., & Möhler, H. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-09-05302.1994 · Cited by 506 · see citing works
Self-citationγ‐Aminobutyric AcidA Receptor α5‐Subunit Creates Novel Type II Benzodiazepine Receptor Pharmacology
Pritchett, D. B., & Seeburg, P. H. (1990) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1990.tb01237.x · Cited by 503 · see citing works
Modulation of inhibitory and excitatory amino acid receptor ion channels by zinc.
Smart, T., Xie, X., & Krishek, B. (1994) · Progress in neurobiology · doi:10.1016/0301-0082(94)90082-5 · Cited by 459 · see citing works
Quaternary Structure of the Native GABAA Receptor Determined by Electron Microscopic Image Analysis
Nayeem, N., Green, T. P., Martin, I. L., & Barnard, E. A. (1994) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1994.62020815.x · Cited by 436 · see citing works
Some properties of brain specific benzodiazepine receptors: New evidence for multiple receptors
Squires, R. F., Benson, D. I., Bræstrup, C., Coupet, J., Klepner, C. A., Myers, V., & Beer, B. (1979) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(79)90341-1 · Cited by 408 · see citing works
Resolution of two biochemically and pharmacologically distinct benzodiazepine receptors
Klepner, C. A., LIPPA, A. S., Benson, D. I., Sano, M. C., & Beer, B. (1979) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(79)90125-4 · Cited by 407 · see citing works
Functional and molecular distinction between recombinant rat GABAA receptor subtypes by Zn2+
Draguhn, A., Verdoorn, T. A., Ewert, M., Seeburg, P. H., & Sakmann, B. J. (1990) · Neuron · doi:10.1016/0896-6273(90)90337-f · Cited by 376 · see citing works
Comparative molecular neuroanatomy of cloned GABAA receptor subunits in the rat CNS
Persohn, E., Malherbe, P., & Richards, J. (1992) · The Journal of comparative neurology · doi:10.1002/cne.903260204 · Cited by 365 · see citing works
Fritschy, J., Benke, D., Mertens, S., Oertel, W., Bächi, T., & Möhler, H. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.15.6726 · Cited by 344 · see citing works
Self-citationFunctional Modulation of GABA A Receptors by cAMP-Dependent Protein Phosphorylation
Moss, S. J., Smart, T. G., Blackstone, C. D., & Huganir, R. L. (1992) · Science · doi:10.1126/science.1323140 · Cited by 341 · see citing works
Assembly of GABAA receptor subunits: role of the delta subunit
Saxena, N., & Macdonald, R. L. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-11-07077.1994 · Cited by 338 · see citing works
Schoch, P., Richards, J. G., Häring, P., et al. (1985) · Nature · doi:10.1038/314168a0 · Cited by 316 · see citing works
Chen, Q. X., Stelzer, A., Kay, A. R., & Wong, R. K. S. (1990) · The Journal of Physiology · doi:10.1113/jphysiol.1990.sp017908 · Cited by 310 · see citing works
Regulation of GABAA receptor function by protein kinase C phosphorylation
Krishek, B. J., Xie, X., Blackstone, C. D., Huganir, R. L., Moss, S. J., & Smart, T. G. (1994) · Neuron · doi:10.1016/0896-6273(94)90316-6 · Cited by 307 · see citing works
Richards, J., Schoch, P., Häring, P., Takács, B., & Möhler, H. (1987) · Journal of Neuroscience · doi:10.1523/jneurosci.07-06-01866.1987 · Cited by 296 · see citing works
Cloning, pharmacological characteristics and expression pattern of the rat GABAA receptor α4 subunit
Wisden, W., Herb, A., Wieland, H., KEINÄNEN, K. P., Lüddens, H., & Seeburg, P. H. (1991) · FEBS Letters · doi:10.1016/0014-5793(91)81076-k · Cited by 260 · see citing works
Olsen, R. W., McCabe, R. T., & Wamsley, J. K. (1990) · PubMed · Cited by 256 · see citing works
Moss, S. J., Doherty, C., & Huganir, R. L. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)49736-6 · Cited by 250 · see citing works
Cyclic AMP-dependent protein kinase decreases GABAA receptor current in mouse spinal neurons
Porter, N. M., Twyman, R. E., Uhler, M. D., & Macdonald, R. L. (1990) · Neuron · doi:10.1016/0896-6273(90)90338-g · Cited by 241 · see citing works
Somogyi, P., Takagi, H., Richards, J. G., & Möhler, H. (1989) · Journal of Neuroscience · doi:10.1523/jneurosci.09-06-02197.1989 · Cited by 234 · see citing works
Angelotti, T., & Macdonald, R. L. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-04-01429.1993 · Cited by 232 · see citing works
Poulter, M., Barker, J. L., O'Carroll, A.-M., et al. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-08-02888.1992 · Cited by 230 · see citing works
Multiple benzodiazepine receptor localization by light microscopic radiohistochemistry.
Young, W. S., Niehoff, D. L., Kuhar, M. J., Beer, B., & LIPPA, A. S. (1981) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)32438-9 · Cited by 227 · see citing works
GABAA receptors display association of γ2-subunit with α1- and β2/3-subunits
Benke, D., Mertens, S., Trzeciak, A. M., Gillessen, D., & Möhler, H. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)64347-2 · Cited by 216 · see citing works
Gao, B., Fritschy, J., Benke, D., & Möhler, H. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90582-z · Cited by 214 · see citing works
Self-citationEthyl β-carboline-3-carboxylate shows differential benzodiazepine receptor interaction
Nielsen, M. B., & Bræstrup, C. (1980) · Nature · doi:10.1038/286606a0 · Cited by 210 · see citing works
Benke, D., Fritschy, J., Trzeciak, A. M., Bannwarth, W., & Möhler, H. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47131-1 · Cited by 204 · see citing works
Self-citationMcKernan, R. M., Quirk, K., Prince, R. J., Cox, P. A., Gillard, N. P., RAGAN, C. I., & Whiting, P. J. (1991) · Neuron · doi:10.1016/0896-6273(91)90379-e · Cited by 194 · see citing works
Sieghart, W., Eichinger, A., Richards, J. G., & Möhler, H. (1987) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1987.tb13125.x · Cited by 191 · see citing works
Mertens, S., Benke, D., & Möhler, H. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53413-x · Cited by 176 · see citing works
Mhatre, M. C., Pena, G., Sieghart, W., & Ticku, M. K. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb09795.x · Cited by 174 · see citing works
Effects of subunit types of the cloned GABAA receptor on the response to a neurosteroid
Shingai, R., Sutherland, M. L., & Barnard, E. A. (1991) · European Journal of Pharmacology Molecular Pharmacology · doi:10.1016/0922-4106(91)90149-c · Cited by 173 · see citing works
Kellenberger, S. B., Malherbe, P., & Sigel, E. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)35656-4 · Cited by 171 · see citing works
Montpied, P., Morrow, A. L., Karanian, J. W., Ginns, E. I., Martin, B. M., & Paul, S. M. (1991) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)10877-8 · Cited by 170 · see citing works
Stoichiometry of a recombinant GABAA receptor deduced from mutation-induced rectification
Backus, K. H., Arigoni, M., Drescher, U., Scheurer, L., Malherbe, P., Möhler, H., & Benson, J. A. (1993) · Neuroreport · doi:10.1097/00001756-199312000-00026 · Cited by 168 · see citing works
Sanger, D. J., Bénavidès, J., Perrault, G., Morel, E., Cohen, C., Joly, D., & Živković, B. (1994) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(94)90049-3 · Cited by 161 · see citing works
de Blas, A., Vitórica, J., & Friedrich, P. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-02-00602.1988 · Cited by 161 · see citing works
Verdoorn, T. A. (1994) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)10020-5 · Cited by 149 · see citing works
Gao, B., & Fritschy, J. M. (1994) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1994.tb00994.x · Cited by 147 · see citing works
Self-citationEwert, M., Shivers, B. D., Lüddens, H., et al. (1990) · The Journal of Cell Biology · doi:10.1083/jcb.110.6.2043 · Cited by 143 · see citing works
Greferath, U., Grünert, U., Fritschy, J., Stephenson, A., Möhler, H., & Wässle, H. (1995) · The Journal of Comparative Neurology · doi:10.1002/cne.903530407 · Cited by 141 · see citing works
Self-citationBohlhalter, S., Möhler, H., & Fritschy, J. (1994) · Brain Research · doi:10.1016/0006-8993(94)90905-9 · Cited by 140 · see citing works
Self-citationWafford, K. A., Bain, C., Whiting, P. J., & Kemp, J. A. (1993) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)13199-4 · Cited by 140 · see citing works
Puia, G., Costa, E., & Vicini, S. (1994) · Neuron · doi:10.1016/0896-6273(94)90157-0 · Cited by 138 · see citing works
The septum and amygdala differentially mediate the anxiolytic effects of benzodiazepines
Pesold, C., & Treit, D. (1994) · Brain Research · doi:10.1016/0006-8993(94)90662-9 · Cited by 137 · see citing works
Leidenheimer, N. J., McQuilkin, S. J., Hahner, L., Whiting, P. J., & Harris, R. A. (1992) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09271-5 · Cited by 132 · see citing works
Hendry, S., Huntsman, M. M., Viñuela, Á., Möhler, H., Blas, A. L. D., & Jones, E. G. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-04-02383.1994 · Cited by 131 · see citing works
Niddam, R., Dubois, A., Scatton, B., et al. (1987) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1987.tb00977.x · Cited by 122 · see citing works
Buck, K. J., Hahner, L., Sikela, J. M., & Harris, R. A. (1991) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1991.tb08313.x · Cited by 119 · see citing works
Zhang, J., Sato, M., & Tohyama, M. (1991) · The Journal of Comparative Neurology · doi:10.1002/cne.903030409 · Cited by 115 · see citing works
Vitórica, J., Park, D., Chin, G. J., & Blas, A. L. D. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-02-00615.1988 · Cited by 114 · see citing works
Müller, T. H., Fritschy, J., Grosche, J., Pratt, G., Möhler, H., & Kettenmann, H. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-05-02503.1994 · Cited by 113 · see citing works
Self-citationBenke, D., Mertens, S., Trzeciak, A. M., Gillessen, D., & Möhler, H. (1991) · FEBS Letters · doi:10.1016/0014-5793(91)80573-l · Cited by 107 · see citing works
Korpi, E. R., & Lüddens, H. (1993) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)13177-5 · Cited by 107 · see citing works
Duggan, M. J., Pollard, S., & Stephenson, F. A. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54297-6 · Cited by 104 · see citing works
Huntsman, M. M., Isackson, P. J., & Jones, E. G. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-04-02236.1994 · Cited by 100 · see citing works
Houser, C. R., Rw, O., Richards, J. G., & Möhler, H. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-04-01370.1988 · Cited by 100 · see citing works
Varečka, Ĺ., Wu, C., Rotter, A., et al. (1994) · The Journal of Comparative Neurology · doi:10.1002/cne.903390304 · Cited by 100 · see citing works
Gao, B., Hornung, J., & Fritschy, J. (1995) · Neuroscience · doi:10.1016/0306-4522(94)00480-s · Cited by 100 · see citing works
Self-citationBiochemical evidence for the existence of gamma-aminobutyrateA receptor iso-oligomers.
Duggan, M. J., & Stephenson, F. A. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)39669-3 · Cited by 99 · see citing works
Chronic ethanol treatment upregulates the GABA receptor β subunit expression
Mhatre, M., & Ticku, M. K. (1994) · Molecular Brain Research · doi:10.1016/0169-328x(94)90231-3 · Cited by 97 · see citing works
Hunter, C., Petralia, R. S., Vu, T., & Wenthold, R. J. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-05-01932.1993 · Cited by 95 · see citing works
The γ3‐subunit of the GABA A ‐receptor confers sensitivity to benzodiazepine receptor ligands
Knoflach, F., Rhyner, T., Villa, M., et al. (1991) · FEBS Letters · doi:10.1016/0014-5793(91)81184-a · Cited by 95 · see citing works
Bénavidès, J., Peny, B., Ruano, D., et al. (1993) · Brain Research · doi:10.1016/0006-8993(93)90375-w · Cited by 95 · see citing works
Gutiérrez, A., Khan, Z. U., & de Blas, A. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-11-07168.1994 · Cited by 93 · see citing works
Immunohistochemical localization of the α1, α2 and α3 subunit of the GABAA receptor in the rat brain
Zimprich, F., Zezula, J., Sieghart, W., & Lassmann, H. (1991) · Neuroscience Letters · doi:10.1016/0304-3940(91)90910-l · Cited by 93 · see citing works
Evidence for central benzodiazepine receptor heterogeneity from behavior tests
Davies, M. F., Onaivi, E. S., Chen, S.-W., Maguire, P. A., Tsai, N. F., & Loew, G. H. (1994) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(94)90455-3 · Cited by 93 · see citing works
Bureau, M., & Olsen, R. W. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb13643.x · Cited by 92 · see citing works
Baude, A., Séquier, J. M., McKernan, R. M., Olivier, K. R., & Somogyi, P. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90513-2 · Cited by 89 · see citing works
Mathews, G. C., Bolos, A. M., Holland, K. D., Isenberg, K. E., Covey, D. F., Ferrendelli, J. A., & Rothman, S. M. (1994) · Neuron · doi:10.1016/0896-6273(94)90465-0 · Cited by 83 · see citing works
Bureau, M., & Olsen, R. W. (1990) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)10839-0 · Cited by 83 · see citing works
Woodward, R. M., Polenzani, L., & Miledi, R. (1992) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)08852-2 · Cited by 81 · see citing works
Gyenes, M., Wang, Q., Gibbs, T. T., et al. (1994) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09732-9 · Cited by 81 · see citing works
Mapping of GABAA receptor α5 and α6 subunit-like immunoreactivity in rat brain
Thompson, C. L., Bodewitz, G., Stephenson, F. A., et al. (1992) · Neuroscience Letters · doi:10.1016/0304-3940(92)90714-i · Cited by 79 · see citing works
Immunochemical Identification of the α1- And α3–Subuntis of the GabaA-Receptor in Rat Brain
Benke, D., Cicin-Sain, A., Mertens, S., & Möhler, H. (1991) · Journal of Receptor Research · doi:10.3109/10799899109066418 · Cited by 77 · see citing works
A prominent epitope on GABAA receptors is recognized by two different monoclonal antibodies
Ewert, M., Blas, A. L. D., Möhler, H., & Seeburg, P. H. (1992) · Brain Research · doi:10.1016/0006-8993(92)90368-j · Cited by 76 · see citing works
Marksitzer, R., Benke, D., Fritschy, J., et al. (1993) · Journal of Receptor Research · doi:10.3109/10799899309073673 · Cited by 76 · see citing works
Self-citationPollard, S., Duggan, M. J., & Stephenson, F. A. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53758-3 · Cited by 74 · see citing works
Localization of NMDA receptor subunit mRNAs in the rat locus coeruleus
Luque, J. M., Malherbe, P., & Richards, J. G. (1995) · Molecular Brain Research · doi:10.1016/0169-328x(94)00253-b · Cited by 74 · see citing works
The GABAA receptor γ1 subunit is expressed by distinct neuronal populations
Araki, T., Kiyama, H., & Tohyama, M. (1992) · Molecular Brain Research · doi:10.1016/0169-328x(92)90159-9 · Cited by 73 · see citing works
Ruano, D., Vizuete, M., Cano, J., et al. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb09747.x · Cited by 71 · see citing works
Quirk, K., Gillard, N. P., RAGAN, C. I., Whiting, P. J., & McKernan, R. M. (1994) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)10555-5 · Cited by 71 · see citing works
Faull, R. L. M., Waldvogel, H. J., Nicholson, L. F. B., & Synek, B. J. L. (1993) · Progress in brain research · doi:10.1016/s0079-6123(08)61341-2 · Cited by 69 · see citing works
Region-specific expression of GABAA receptor α3 and α4 subunits mRNAs in the rat brain
Araki, T., & Tohyama, M. (1992) · Molecular Brain Research · doi:10.1016/0169-328x(92)90132-u · Cited by 67 · see citing works
Machu, T. K., Firestone, J. A., & Browning, M. D. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb03582.x · Cited by 67 · see citing works
Short and Long Form γ2 Subunits of the GABAA/Benzodiazepine Receptors
Khan, Z. U., Gutiérrez, A., & Blas, A. L. D. (1994) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1994.63041466.x · Cited by 66 · see citing works
Soltész, I., Roberts, J. D. B., Takagi, H., Richards, J. G., Möhler, H., & Somogyi, P. (1990) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1990.tb00434.x · Cited by 66 · see citing works
Li, H., Siegel, R. E., & Schwartz, R. D. (1993) · Hippocampus · doi:10.1002/hipo.450030412 · Cited by 62 · see citing works
Effects of subunit types of the recombinant GABAA receptor on the response to a neurosteroid
Zaman, S. H., Shingai, R., Harvey, R. J., Darlison, M. G., & Barnard, E. A. (1992) · European Journal of Pharmacology Molecular Pharmacology · doi:10.1016/0922-4106(92)90106-6 · Cited by 61 · see citing works
Antibodies Specific for α‐Subunit Subtypes of GABAA Receptors Reveal Brain Regional Heterogeneity
Endo, S., & Olsen, R. W. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb03300.x · Cited by 60 · see citing works
Localization of GABAA receptor subunit mRNAs in the rat locus coeruleus
Luque, J. M., Malherbe, P., & Richards, J. G. (1994) · Molecular Brain Research · doi:10.1016/0169-328x(94)90135-x · Cited by 58 · see citing works
Localization of GABAA-receptor γ2-subunit mRNA-containing neurons in the rat central nervous system
Araki, T., Sato, M., Kiyama, H., Manabe, Y., & Tohyama, M. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90119-m · Cited by 57 · see citing works
GABAA receptor α1 subunit, an early marker for area specification in developing rat cerebral cortex
Paysan, J., Möhler, H., Fritschy, J., et al. (1994) · The Journal of Comparative Neurology · doi:10.1002/cne.903500110 · Cited by 57 · see citing works
Self-citationModulation of GABA‐gated chloride currents by intracellular Ca2+ in cultured porcine melanotrophs.
Mouginot, D., FELTZ, P., & Schlichter, R. (1991) · The Journal of Physiology · doi:10.1113/jphysiol.1991.sp018587 · Cited by 52 · see citing works
Tögel, M., Mossier, B., Fuchs, K., et al. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)99974-6 · Cited by 50 · see citing works
Bénavidès, J., Peny, B., Durand, A., Arbilla, S., & Scatton, B. (1992) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)10428-x · Cited by 50 · see citing works
Massotti, M., Schlichting, J., Antonacci, M. D., Giusti, P., Memo, M., Costa, E., & Guidotti, A. (1990) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)23063-4 · Cited by 46 · see citing works
Functional Heterogeneity of Hippocampal GABAA Receptors
Schönrock, B., & Bormann, J. (1993) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1993.tb00957.x · Cited by 44 · see citing works
Browning, M. D., Endo, S., Smith, G. B., Dudek, E. M., & Olsen, R. W. (1993) · Neurochemical Research · doi:10.1007/bf00966927 · Cited by 41 · see citing works
Schwartz, R. D., Wagner, J. P., Yu, X., et al. (1994) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1994.62030916.x · Cited by 38 · see citing works
Duggan, M. J., Pollard, S., & Stephenson, F. A. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb09278.x · Cited by 37 · see citing works
Persistent elevation in GABAA receptor subunit mRNAs following social stress
Kang, I., Thompson, M. L., Heller, J., & Miller, L. G. (1991) · Brain Research Bulletin · doi:10.1016/0361-9230(91)90179-n · Cited by 35 · see citing works
GABAA-receptor immunoreactivity in the rat dorsal thalamus: An ultrastructural investigation
Spreafico, R., Biasi, S. D., Amadeo, A., et al. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90272-m · Cited by 29 · see citing works
Molecular characterization of Type I GABAA receptor complex from rat cerebral cortex and hippocampus
Ruano, D., Araujo, F., Machado, A., et al. (1994) · Molecular Brain Research · doi:10.1016/0169-328x(94)90157-0 · Cited by 29 · see citing works
Bravo, H., & Karten, H. J. (1992) · The Journal of Comparative Neurology · doi:10.1002/cne.903200104 · Cited by 27 · see citing works
Immunocytochemical detection of astrocyte GABAA receptors in cat visual cortex.
Rosier, A. M., Arckens, L., Orban, G. A., et al. (1993) · Journal of Histochemistry & Cytochemistry · doi:10.1177/41.5.8385682 · Cited by 26 · see citing works
Distribution of GABAA-receptor α1 subunit gene expression in the rat forebrain
Zhang, J., Araki, T., Sato, M., & Tohyama, M. (1991) · Molecular Brain Research · doi:10.1016/0169-328x(91)90032-s · Cited by 23 · see citing works
Negro, M., Chinchetru, M. A., Fernández‐López, A., & Calvo, P. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb10069.x · Cited by 13 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Cortical inhibitory neurons and schizophrenia
Lewis, D. A., Hashimoto, T., & Volk, D. W. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1648 · Cited by 2,297 · see citing works
Neurocircuitry of stress: central control of the hypothalamo–pituitary–adrenocortical axis
Herman, J. P., & Cullinan, W. E. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)10069-2 · Cited by 2,270 · see citing works
Variations on an inhibitory theme: phasic and tonic activation of GABAA receptors
Farrant, M., & Nusser, Z. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1625 · Cited by 2,081 · see citing works
GABA<sub>A</sub> Receptor Channels
Macdonald, R. L., & Olsen, R. W. (1994) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.17.030194.003033 · Cited by 1,975 · see citing works
the GIANT Consortium (2009) · Nature Genetics · doi:10.1038/ng.287 · Cited by 1,720 · see citing works
Benzodiazepine actions mediated by specific γ-aminobutyric acidA receptor subtypes
Rudolph, U., Crestani, F., Benke, D., Brünig, I., Benson, J. A., Fritschy, J.-M., Martin, J. R., Bluethmann, H., & Möhler, H. (1999) · Nature · doi:10.1038/44579 · Cited by 1,172 · see citing works
Self-citationOlsen, R. W., & Sieghart, W. (2008) · Pharmacological Reviews · doi:10.1124/pr.108.00505 · Cited by 1,064 · see citing works
The GABAergic deficit hypothesis of major depressive disorder
Luscher, B., Shen, Q., & Sahir, N. (2011) · Molecular Psychiatry · doi:10.1038/mp.2010.120 · Cited by 934 · see citing works
Molecular and neuronal substrate for the selective attenuation of anxiety
Löw, K., Crestani, F., Keist, R., Benke, D., Brünig, I., Benson, J. A., Fritschy, J.-M., Rülicke, T., Bluethmann, H., Möhler, H., et al. (2000) · Science · doi:10.1126/science.290.5489.131 · Cited by 946 · see citing works
Self-citationMcKernan, R. M., Rosahl, T. W., Reynolds, D. S., Sur, C., Wafford, K. A., Atack, J. R., Farrar, S., Myers, J., Cook, G., Ferris, P., et al. (2000) · Nature Neuroscience · doi:10.1038/75761 · Cited by 944 · see citing works
Neurosteroids: biosynthesis and function of these novel neuromodulators
Compagnone, N. A., & Mellon, S. H. (2000) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1999.0188 · Cited by 820 · see citing works
Beyond classical benzodiazepines: novel therapeutic potential of GABAA receptor subtypes
Rudolph, U., & Knoflach, F. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3502 · Cited by 733 · see citing works
A new benzodiazepine pharmacology
Möhler, H., Fritschy, J. M., & Rudolph, U. (2002) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.300.1.2 · Cited by 716 · see citing works
Self-citationCollinson, N., Kuenzi, F. M., Jarolimek, W., Maubach, K. A., Cothliff, R., Sur, C., Smith, A., Otu, F. M., Howell, O., Atack, J. R., et al. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-13-05572.2002 · Cited by 628 · see citing works
Trace fear conditioning involves hippocampal α <sub>5</sub> GABA <sub>A</sub> receptors
Crestani, F., Keist, R., Fritschy, J.-M., Benke, D., Vogt, K., Prut, L., Blüthmann, H., Möhler, H., & Rudolph, U. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.142288699 · Cited by 528 · see citing works
Self-citationHashimoto, T., Arion, D., Unger, T., Maldonado-Avilés, J. G., Morris, H. M., Volk, D. W., Mirnics, K., & Lewis, D. A. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002011 · Cited by 490 · see citing works
GABA-based therapeutic approaches: GABAA receptor subtype functions
RUDOLPH, U., & MOHLER, H. (2006) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2005.10.003 · Cited by 499 · see citing works
Self-citationNusser, Z., Hájos, N., Somogyi, P., & Mody, I. (1998) · Nature · doi:10.1038/25999 · Cited by 483 · see citing works
Hashimoto, T., Bazmi, H. H., Mirnics, K., Wu, Q., Sampson, A. R., & Lewis, D. A. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.07081223 · Cited by 457 · see citing works
Meyer, U., Nyffeler, M., Yee, B. K., Knuesel, I., & Feldon, J. (2008) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2007.09.012 · Cited by 457 · see citing works
Reversal of pathological pain through specific spinal GABAA receptor subtypes
Knabl, J., Witschi, R., Hösl, K., Reinold, H., Zeilhofer, U. B., Ahmadi, S., Brockhaus, J., Sergejeva, M., Hess, A., Brune, K., et al. (2008) · Nature · doi:10.1038/nature06493 · Cited by 438 · see citing works
Self-citationNeural bases for addictive properties of benzodiazepines
Tan, K. R., Brown, M., Labouèbe, G., Yvon, C., Creton, C., Fritschy, J.-M., Rudolph, U., & Lüscher, C. (2010) · Nature · doi:10.1038/nature08758 · Cited by 397 · see citing works
Self-citationGeneral anaesthetic actions on ligand-gated ion channels
Krasowski, M. D., & Harrison, N. L. (1999) · Cellular and Molecular Life Sciences (CMLS) · doi:10.1007/s000180050371 · Cited by 384 · see citing works
Rapid Signaling at Inhibitory Synapses in a Dentate Gyrus Interneuron Network
Bartos, M., Vida, I., Frotscher, M., Geiger, J. R. P., & Jonas, P. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-08-02687.2001 · Cited by 325 · see citing works
Sharma, P., Srivastava, P., Seth, A., Tripathi, P. N., Banerjee, A. G., & Shrivastava, S. K. (2019) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2018.12.006 · Cited by 331 · see citing works
Postnatal Differentiation of Basket Cells from Slow to Fast Signaling Devices
Doischer, D., Aurel Hosp, J., Yanagawa, Y., Obata, K., Jonas, P., Vida, I., & Bartos, M. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.2890-08.2008 · Cited by 248 · see citing works
GABAergic dysfunction in schizophrenia: new treatment strategies on the horizon
Guidotti, A., Auta, J., Davis, J. M., Dong, E., Grayson, D. R., Veldic, M., Zhang, X., & Costa, E. (2005) · Psychopharmacology · doi:10.1007/s00213-005-2212-8 · Cited by 262 · see citing works
Lewis, D., Volk, D., & Hashimoto, T. (2004) · Psychopharmacology · doi:10.1007/s00213-003-1673-x · Cited by 253 · see citing works
Brünig, I., Penschuck, S., Berninger, B., Benson, J., & Fritschy, J. (2001) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01506.x · Cited by 247 · see citing works
Self-citationPeng, Z., Hauer, B., Mihalek, R. M., Homanics, G. E., Sieghart, W., Olsen, R. W., & Houser, C. R. (2002) · Journal of Comparative Neurology · doi:10.1002/cne.10210 · Cited by 247 · see citing works
Lee, V., & Maguire, J. (2014) · Frontiers in Neural Circuits · doi:10.3389/fncir.2014.00003 · Cited by 228 · see citing works
McGregor, I. S., Hargreaves, G. A., Apfelbach, R., & Hunt, G. E. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.0187-04.2004 · Cited by 231 · see citing works
“, 1999) and contains GABA subunit configurations that bind benzodiazepines (Laurie et al., 1992; Fritschy and Mohler, 1995).”
Han, S., Tai, C., Jones, C. J., Scheuer, T., & Catterall, W. A. (2014) · Neuron · doi:10.1016/j.neuron.2014.01.016 · Cited by 231 · see citing works
Patterns of mRNA and protein expression for 12 GABAA receptor subunits in the mouse brain
Hörtnagl, H., Tasan, R. O., Wieselthaler, A., Kirchmair, E., Sieghart, W., & Sperk, G. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.01.008 · Cited by 229 · see citing works
An emerging circuit pharmacology of GABAA receptors
Engin, E., Benham, R. S., & Rudolph, U. (2018) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2018.04.003 · Cited by 225 · see citing works
Downregulation of Tonic GABAergic Inhibition in a Mouse Model of Fragile X Syndrome
Curia, G., Papouin, T., Séguéla, P., & Avoli, M. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhn159 · Cited by 218 · see citing works
Regulation of GABAA Receptor Subunit Expression by Pharmacological Agents
Uusi-Oukari, M., & Korpi, E. R. (2010) · Pharmacological Reviews · doi:10.1124/pr.109.002063 · Cited by 213 · see citing works
Towards a Better Understanding of GABAergic Remodeling in Alzheimer’s Disease
Govindpani, K., Calvo-Flores Guzmán, B., Vinnakota, C., Waldvogel, H., Faull, R., & Kwakowsky, A. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18081813 · Cited by 208 · see citing works
Ferguson, B. R., & Gao, W.-J. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.11.033 · Cited by 186 · see citing works
Yee, B. K., Keist, R., von Boehmer, L., Studer, R., Benke, D., Hagenbuch, N., Dong, Y., Malenka, R. C., Fritschy, J.-M., Bluethmann, H., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508752102 · Cited by 201 · see citing works
Self-citationHashimoto, T., Nguyen, Q. L., Rotaru, D., Keenan, T., Arion, D., Beneyto, M., Gonzalez-Burgos, G., & Lewis, D. A. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.01.004 · Cited by 151 · see citing works
Gunn, B. G., Cunningham, L., Cooper, M. A., Corteen, N. L., Seifi, M., Swinny, J. D., Lambert, J. J., & Belelli, D. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.1337-13.2013 · Cited by 151 · see citing works
Inhibitory control of hippocampal inhibitory neurons
Chamberland, S., & Topolnik, L. (2012) · Frontiers in Neuroscience · doi:10.3389/fnins.2012.00165 · Cited by 134 · see citing works
GABAergic Control of Depression-Related Brain States
Luscher, B., & Fuchs, T. (2015) · Advances in Pharmacology · doi:10.1016/bs.apha.2014.11.003 · Cited by 149 · see citing works
GABAA receptor-acting neurosteroids: a role in the development and regulation of the stress response
Gunn, B. G., Cunningham, L., Mitchell, S. G., Swinny, J. D., Lambert, J. J., & Belelli, D. (2015) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.06.001 · Cited by 149 · see citing works
Early developmental alterations in GABAergic protein expression in fragile X knockout mice
Adusei, D. C., Pacey, L. K. K., Chen, D., & Hampson, D. R. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.05.002 · Cited by 139 · see citing works
Ali, A. B., & Thomson, A. M. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhm160 · Cited by 129 · see citing works
Nyffeler, M., Meyer, U., Yee, B. K., Feldon, J., & Knuesel, I. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.07.029 · Cited by 139 · see citing works
Synaptic Properties of SOM- and CCK-Expressing Cells in Dentate Gyrus Interneuron Networks
Savanthrapadian, S., Meyer, T., Elgueta, C., Booker, S. A., Vida, I., & Bartos, M. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.5433-13.2014 · Cited by 119 · see citing works
Fischell, J., Van Dyke, A. M., Kvarta, M. D., LeGates, T. A., & Thompson, S. M. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.112 · Cited by 122 · see citing works
Drug targets for cognitive enhancement in neuropsychiatric disorders.
Wallace, T. L., Ballard, T. M., Pouzet, B., Riedel, W. J., & Wettstein, J. G. (2011) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.03.022 · Cited by 127 · see citing works
Wegner, F., Härtig, W., Bringmann, A., Grosche, J., Wohlfarth, K., Zuschratter, W., & Brückner, G. (2003) · Experimental Neurology · doi:10.1016/s0014-4886(03)00313-3 · Cited by 107 · see citing works
Antidepressant-like properties of α2-containing GABAA receptors
Vollenweider, I., Smith, K. S., Keist, R., & Rudolph, U. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.10.009 · Cited by 96 · see citing works
GABAergic regulation of the HPA and HPG axes and the impact of stress on reproductive function
Camille Melón, L., & Maguire, J. (2016) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2015.11.019 · Cited by 94 · see citing works
Smith, K. S., Engin, E., Meloni, E. G., & Rudolph, U. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.03.001 · Cited by 94 · see citing works
Chapter 2 Hypothalamic Neural Systems Controlling the Female Reproductive Life Cycle
(2009) · International Review of Cell and Molecular Biology · doi:10.1016/s1937-6448(08)02002-9 · Cited by 93 · see citing works
A precritical period for plasticity in visual cortex
Feller, M. B., & Scanziani, M. (2005) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2005.01.012 · Cited by 92 · see citing works
Modulation of anxiety and fear via distinct intrahippocampal circuits
Engin, E., Smith, K. S., Gao, Y., Nagy, D., Foster, R. A., Tsvetkov, E., Keist, R., Crestani, F., Fritschy, J.-M., Bolshakov, V. Y., et al. (2016) · eLife · doi:10.7554/elife.14120 · Cited by 91 · see citing works
Self-citationEngin, E., Zarnowska, E. D., Benke, D., Tsvetkov, E., Sigal, M., Keist, R., Bolshakov, V. Y., Pearce, R. A., & Rudolph, U. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.1370-15.2015 · Cited by 79 · see citing works
Cheng, T., Wallace, D. M., Ponteri, B. B., & Tuli, M. (2018) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s164307 · Cited by 66 · see citing works
Gonzalez-Burgos, G., Miyamae, T., Pafundo, D. E., Yoshino, H., Rotaru, D. C., Hoftman, G., Datta, D., Zhang, Y., Hammond, M., Sampson, A. R., et al. (2015) · Cerebral Cortex · doi:10.1093/cercor/bhu122 · Cited by 64 · see citing works
Renard, J., Rushlow, W. J., & Laviolette, S. R. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00281 · Cited by 62 · see citing works
Treating enhanced GABAergic inhibition in Down syndrome: Use of GABA α5-selective inverse agonists
Martínez-Cué, C., Delatour, B., & Potier, M.-C. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.12.008 · Cited by 58 · see citing works
Atack, J. R. (2009) · Advances in Pharmacology · doi:10.1016/s1054-3589(08)57004-9 · Cited by 52 · see citing works
Willi, R., Weinmann, O., Winter, C., Klein, J., Sohr, R., Schnell, L., Yee, B. K., Feldon, J., & Schwab, M. E. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4393-09.2010 · Cited by 52 · see citing works
Neurogliaform cells of amygdala: a source of slow phasic inhibition in the basolateral complex
Mańko, M., Bienvenu, T. C. M., Dalezios, Y., & Capogna, M. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2012.236745 · Cited by 51 · see citing works
Katona, L., Micklem, B., Borhegyi, Z., Swiejkowski, D. A., Valenti, O., Viney, T. J., Kotzadimitriou, D., Klausberger, T., & Somogyi, P. (2017) · Hippocampus · doi:10.1002/hipo.22696 · Cited by 50 · see citing works
Reynolds, L. M., Engin, E., Tantillo, G., Lau, H. M., Muschamp, J. W., Carlezon, W. A., & Rudolph, U. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.115 · Cited by 49 · see citing works
Wiltgen, B. (2009) · Frontiers in Behavioral Neuroscience · doi:10.3389/neuro.08.037.2009 · Cited by 47 · see citing works
Heldt, S. A., & Ressler, K. J. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.0693-10.2010 · Cited by 42 · see citing works
Engin, E., Bakhurin, K. I., Smith, K. S., Hines, R. M., Reynolds, L. M., Tang, W., Sprengel, R., Moss, S. J., & Rudolph, U. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.41 · Cited by 40 · see citing works
Troppoli, T. A., Zanos, P., Georgiou, P., Gould, T. D., Rudolph, U., & Thompson, S. M. (2022) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.11.024 · Cited by 29 · see citing works
Popova, D., Ágústsdóttir, A., Lindholm, J., Mazulis, U., Akamine, Y., Castrén, E., & Karpova, N. N. (2014) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2014.04.002 · Cited by 26 · see citing works
Mohammadi, N. A., Ahring, P. K., Yu Liao, V. W., Chua, H. C., Ortiz de la Rosa, S., Johannesen, K. M., Michaeli-Yossef, Y., Vincent-Devulder, A., Meridda, C., Bruel, A.-L., et al. (2024) · eBioMedicine · doi:10.1016/j.ebiom.2024.105236 · Cited by 27 · see citing works
Ghafari, M., Falsafi, S. K., Szodorai, E., Kim, E.-J., Li, L., Höger, H., Berger, J., Fuchs, K., Sieghart, W., & Lubec, G. (2017) · Brain Structure and Function · doi:10.1007/s00429-016-1233-x · Cited by 19 · see citing works
Searching for new pharmacological targets for the treatment of Alzheimer's disease in Down syndrome
Caraci, F., Iulita, M. F., Pentz, R., Flores Aguilar, L., Orciani, C., Barone, C., Romano, C., Drago, F., & Cuello, A. C. (2017) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2017.10.004 · Cited by 18 · see citing works
Tong, X., Peng, Z., Zhang, N., Cetina, Y., Huang, C. S., Wallner, M., Otis, T. S., & Houser, C. R. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.2853-15.2015 · Cited by 15 · see citing works
Fritz, B. M., & Boehm II, S. L. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.07.020 · Cited by 10 · see citing works
- Authors
- Fritschy, J., & Mohler, H.
- Affiliations
- University of Zurich (CH)
- Corresponding author
- Fritschy, Jean‐Marc
- ORCID
- Fritschy, Jean‐Marc
- Venue
- Journal of Comparative Neurology
- Publisher
- Wiley
- Published
- 1995-08-14
- Volume
- 359
- Issue
- 1
- Pages
- 154-194
- ISSN
- 0021-9967 (ISSN-L)
- 1096-9861
- OpenAlex
- W2039738625
- Cited by
- 1,244
- References
- 125
- Citations by year
- 2026: 17 · 2025: 11 · 2024: 24 · 2023: 15 · 2022: 24 · 2021: 35 · 2020: 28 · 2019: 19 · 2018: 33 · 2017: 31 · 2016: 33 · 2015: 24 · 2014: 46 · 2013: 28 · 2012: 45
- FWCI
- 14.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Comparative Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Keywords
- GABAA receptor, benzodiazepine binding site, subunit stoichiometry, regional distribution, neuronal cell types, GABAergic interneurons, GABAergic projection neurons
- MeSH terms
- Amygdala, Animals, Basal Ganglia, Brain Chemistry, Brain Stem, Cerebellum, Cerebral Cortex, Fluorescent Antibody Technique, Hypothalamus, Immunohistochemistry, Male, Neurons, Olfactory Bulb, Receptors, GABA-A, Subcellular Fractions, Superior Colliculi, Thalamus, Prosencephalon, Rats, Sprague-Dawley, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review