Cited by 274Antioxidant Activity and Oxidative StressAlcohol Consumption and Health EffectsRedox biology and oxidative stress

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Ethanol‐Induced Oxygen Radical Formation and Lipid Peroxidation in Rat Brain: Effect of Chronic Alcohol Consumption

Montoliu, Carmina, Vallés, Soraya, Renau‐Piqueras, Jaime, Guerri, Consuelo·1994·Journal of Neurochemistry

DOI 10.1046/j.1471-4159.1994.63051855.x

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Abstract

Abstract: The effect of chronic and in vitro ethanol exposure on brain oxygen radical formation and lipid peroxidation was analyzed. Ethanol induces a dose‐dependent increase in lipid peroxidation in brain homogenates. The peroxidative effects of alcohol seem to be related to both cytochrome P450 and the ethanol‐inducible form of cytochrome P450 (CYP2E1), because preincubation with metyrapone (an inhibitor of cytochrome P450) or with an antibody against CYP2E1 abolished the ethanol‐increased lipid peroxidation. Using the formation of dichlorofluorescein, we also demonstrated that both in vitro and chronic alcohol exposure significantly enhanced the formation of oxygen radical species in synaptosomes. Chronic alcohol treatment also leads to an induction of cytochrome P450 (230%), NADPH cytochrome c reductase (180%), NADPH oxidation (184%), and CYP2E1 in brain microsomes. In addition, this treatment produced a decrease in the GSH/GSSG ratio in brain and significantly enhanced the levels of superoxide dismutase and catalase activities. This mechanism could be involved in the toxic effects of ethanol on brain and membrane alterations occurring after chronic ethanol intake.

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Protective effect of pineapple (Ananas cosmosus) peel extract on alcohol–induced oxidative stress in brain tissues of male albino rats
Erukainure, O. L., Ajiboye, J. A., Adejobi, R., Okafor, O., & Adenekan, S. O. (2011) · Asian Pacific Journal of Tropical Disease · doi:10.1016/s2222-1808(11)60002-9 · Cited by 52
“Several studies have shown that chronic alcohol consumption leads to several metabolic disorders including hepatic and extra hepatic diseases, which are instigated by reactive oxygen species (ROS) generation as found in liver, heart and brain, leading to cellular damage[1-4].”
Background
Supraphysiologic-dose anabolic–androgenic steroid use: A risk factor for dementia?
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Comparison of the deleterious effects of binge drinking‐like alcohol exposure in adolescent and adult mice
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Estrogen Neuroprotection Against the Neurotoxic Effects of Ethanol Withdrawal: Potential Mechanisms
Jung, M. E., Gatch, M. B., & Simpkins, J. W. (2005) · Experimental Biology and Medicine · doi:10.1177/153537020523000102 · Cited by 49
Differential protein expression profiles in the hippocampus of human alcoholics
Matsuda-Matsumoto, H., Iwazaki, T., Kashem, M. A., Harper, C., & Matsumoto, I. (2007) · Neurochemistry International · doi:10.1016/j.neuint.2007.04.001 · Cited by 50
Butyrate Improves Neuroinflammation and Mitochondrial Impairment in Cerebral Cortex and Synaptic Fraction in an Animal Model of Diet-Induced Obesity
Cavaliere, G., Catapano, A., Trinchese, G., Cimmino, F., Penna, E., Pizzella, A., Cristiano, C., Lama, A., Crispino, M., & Mollica, M. P. (2022) · Antioxidants · doi:10.3390/antiox12010004 · Cited by 52
“The levels of ROS were determined as previously reported [30].”
Method
Impaired one carbon metabolism and DNA methylation in alcohol toxicity
Kruman, I. I., & Fowler, A. (2014) · Journal of Neurochemistry · doi:10.1111/jnc.12677 · Cited by 48
“Acetaldehyde production is the first step of ethanol metabolism, which is accompanied by formation of reactive oxygen species (ROS) which has been shown to occur in brain as well (Montoliu et al. 1994; Haorah et al. 2008).”
Background
Manganese accentuates adverse mental health effects associated with alcohol use disorders
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Acetaldehyde cytotoxicity in cultured rat astrocytes
Hołownia, A., Ledig, M., Braszko, J. J., & Menez, J. F. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01529-2 · Cited by 45
Nitric oxide modulates retinal ganglion cell axon arbor remodelingin vivo
Cogen, J., & Cohen‐Cory, S. (2000) · Journal of Neurobiology · doi:10.1002/1097-4695(20001105)45:2 · Cited by 42
Intravenous administration of anti-inflammatory mesenchymal stem cell spheroids reduces chronic alcohol intake and abolishes binge-drinking
Ezquer, F. E., Morales, P., Quintanilla, M. E., Santapau, D., Lespay‐Rebolledo, C., Ezquer, M., Herrera‐Marschitz, M., & Israel, Y. (2018) · Scientific Reports · doi:10.1038/s41598-018-22750-7 · Cited by 46
Ethanol Influences on Bax Translocation, Mitochondrial Membrane Potential, and Reactive Oxygen Species Generation Are Modulated by Vitamin E and Brain‐Derived Neurotrophic Factor
Heaton, M. B., Paiva, M., & Siler‐Marsiglio, K. I. (2011) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2011.01445.x · Cited by 45
“Ethanol enhances generation of destructive reactive oxygen species (ROS), often with concomitant reductions in the expression or activity of protective endogenous antioxidants (Uysal et al., 1989; Davis et al., 1990; Montoliu et al., 1994; Henderson et al., 1995; Kotch et al., 1995; Reddy et al., 1999; Heaton et al.,…”
Background
Regional and cellular distribution of CYP2E1 in monkey brain and its induction by chronic nicotine
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Paraquat-Induced Free Radical Reaction in Mouse Brain Microsomes
Yang, W., & Sun, A. Y. (1998) · Neurochemical Research · doi:10.1023/a:1022497319548 · Cited by 45
“In view of the finding that cytochrome P450 enzyme was present in the brain (40-41), mouse brain microsomes were used to evaluate the ability of paraquat to induce lipid peroxidation.”
Method
Cytochrome P450 2E1 in the substantia nigra: Relevance for dopaminergic neurotransmission and free radical production
Shahabi, H. N., Andersson, D. R., & Nissbrandt, H. (2008) · Synapse · doi:10.1002/syn.20505 · Cited by 44
Mesenchymal stem cells inhibition of chronic ethanol-induced oxidative damage via upregulation of phosphatidylinositol-3-kinase/Akt and modulation of extracellular signal-regulated kinase 1/2 activation in PC12 cells and neurons
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Roles of Oxidative Stress and Autophagy in Alcohol-Mediated Brain Damage
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“However, it is important to consider the potential impacts of the elevated CYP2E1 on the oxidative cell and brain injury, since CYP2E1 was shown to be induced by 17.5 mM ethanol in primary neuronal cells [61], primary astrocytes [62], and rodent brains after chronic alcohol exposures [63–66].”
Influential
Immune function genes, genetics, and the neurobiology of addiction
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Aspirin and N‐acetylcysteine co‐administration markedly inhibit chronic ethanol intake and block relapse binge drinking: Role of neuroinflammation‐oxidative stress self‐perpetuation
Israel, Y., Quintanilla, M. E., Ezquer, F. E., Morales, P., Santapau, D., Berríos‐Cárcamo, P., Ezquer, M., Olivares, B., & Herrera‐Marschitz, M. (2019) · Addiction Biology · doi:10.1111/adb.12853 · Cited by 45
Alpha-lipoic acid prevents ethanol-induced protein oxidation in mouse hippocampal HT22 cells
Pirlich, M., Kiok, K., Sandig, G., et al. (2002) · Neuroscience Letters · doi:10.1016/s0304-3940(02)00415-9 · Cited by 41
Ethanol Induced Changes in Superoxide Anion and Nitric Oxide in Cultured Microglia
Colton, C. A., Snell‐Callanan, J., & Chernyshev, O. N. (1998) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1998.tb04315.x · Cited by 41
Changes in some pro-and antioxidants in rat cerebellum after chronic alcohol intake
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N-Palmitoylethanolamide protects the kidney from hypertensive injury in spontaneously hypertensive rats via inhibition of oxidative stress
Raso, G. M., Simeoli, R., Russo, R., Santoro, A. N., Pirozzi, C., Bianca, R. D. D. V., Mitidieri, E., Paciello, O., Pagano, T. B., Orefice, N. S., et al. (2013) · Pharmacological Research · doi:10.1016/j.phrs.2013.07.007 · Cited by 40
Protecting neurons from HIV-1 gp120-induced oxidant stress using both localized intracerebral and generalized intraventricular administration of antioxidant enzymes delivered by SV40-derived vectors
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Changes in Serum Retinol, α-Tocopherol, Vitamin C, Carotenoids, Zinc and Selenium after Micronutrient Supplementation during Alcohol Rehabilitation
Guéguen, S., Pirollet, P., Leroy, P., Guilland, J.-C., Arnaud, J., Paillé, F., Siest, G., Visvikis‐Siest, S., Herçberg, S., & Herbeth, B. (2003) · Journal of the American College of Nutrition · doi:10.1080/07315724.2003.10719308 · Cited by 41
Vermal atrophy of alcoholics correlate with serum thiamine levels but not with dentate iron concentrations as estimated by MRI
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“It appears that ethanol-induced neurotoxicity is mediated by oxidative stress and mitochondrial malfunction [11, 13, 25].”
Background

Authors: Montoliu, C., Vallés, S., Renau‐Piqueras, J., & Guerri, C.
Affiliations: Instituto de Investigación Sanitaria La Fe (ES)
Corresponding author: Guerri, Consuelo
ORCID: Vallés, Soraya
Guerri, Consuelo
Venue: Journal of Neurochemistry
Publisher: Wiley
Published: 1994-11
Volume: 63
Issue: 5
Pages: 1855-1862
ISSN: 0022-3042 (ISSN-L)
1471-4159
DOI: 10.1046/j.1471-4159.1994.63051855.x
OpenAlex: W1978987336
Cited by: 269
References: 0
Citations by year: 2026: 2 · 2025: 2 · 2024: 2 · 2023: 3 · 2022: 5 · 2021: 4 · 2020: 1 · 2019: 7 · 2018: 10 · 2017: 6 · 2016: 9 · 2015: 10 · 2014: 10 · 2013: 5 · 2012: 13
FWCI: 6.86
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 2944 d)
Locations: Journal of Neurochemistry (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords: chronic alcohol consumption, oxygen free radicals, lipid peroxidation, brain, cytochrome P450, CYP2E1, metyrapone, dichlorofluorescein, synaptosomes, NADPH-cytochrome c reductase, NADPH oxidation, glutathione, superoxide dismutase, catalase, ethanol neurotoxicity, brain microsomes
MeSH terms: Ethanol, Alcoholism, Animals, Brain, Brain Chemistry, Catalase, Cytochrome P-450 Enzyme System, Dose-Response Relationship, Drug, Electrophoresis, Polyacrylamide Gel, Female, Free Radicals, Glutathione, Isomerism, NADP, Oxygen, Superoxide Dismutase, Synaptosomes, Immunoblotting, Lipid Peroxidation, Rats, Wistar, Reactive Oxygen Species, Glutathione Disulfide, Rats

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Ethanol‐Induced Oxygen Radical Formation and Lipid Peroxidation in Rat Brain: Effect of Chronic Alcohol Consumption

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