Cited by 274Antioxidant Activity and Oxidative StressAlcohol Consumption and Health EffectsRedox biology and oxidative stress

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Ethanol‐Induced Oxygen Radical Formation and Lipid Peroxidation in Rat Brain: Effect of Chronic Alcohol Consumption

Montoliu, Carmina, Vallés, Soraya, Renau‐Piqueras, Jaime, Guerri, Consuelo·1994·Journal of Neurochemistry

DOI 10.1046/j.1471-4159.1994.63051855.x

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Abstract

Abstract: The effect of chronic and in vitro ethanol exposure on brain oxygen radical formation and lipid peroxidation was analyzed. Ethanol induces a dose‐dependent increase in lipid peroxidation in brain homogenates. The peroxidative effects of alcohol seem to be related to both cytochrome P450 and the ethanol‐inducible form of cytochrome P450 (CYP2E1), because preincubation with metyrapone (an inhibitor of cytochrome P450) or with an antibody against CYP2E1 abolished the ethanol‐increased lipid peroxidation. Using the formation of dichlorofluorescein, we also demonstrated that both in vitro and chronic alcohol exposure significantly enhanced the formation of oxygen radical species in synaptosomes. Chronic alcohol treatment also leads to an induction of cytochrome P450 (230%), NADPH cytochrome c reductase (180%), NADPH oxidation (184%), and CYP2E1 in brain microsomes. In addition, this treatment produced a decrease in the GSH/GSSG ratio in brain and significantly enhanced the levels of superoxide dismutase and catalase activities. This mechanism could be involved in the toxic effects of ethanol on brain and membrane alterations occurring after chronic ethanol intake.

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Background
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“Chronic ethanol consumption has been associated with an increased content of cytochrome P450 2E1 (Montoliu et al., 1994; Tindberg and Ingelman-Sundberg, 1996) and in the formation of reactive oxygen species (Montoliu et al.”
BackgroundInfluential
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Repeated Cycles of Binge‐Like Ethanol Exposure Induces Neurobehavioral Changes During Short‐ and Long‐Term Withdrawal in Adolescent Female Rats
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“Previous studies, including ours (Sun and Mayhan, 2001), suggested that alcohol consumption induces oxidative stress (Agar et al., 1999; Montoliu et al., 1994; Omodeo-Sale et al., 1997; Sun et al., 2001; Yin et al., 2001).”
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Study of the potential oxidative stress induced by six solvents in the rat brain
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“High CYP activity is associated with cellular oxidative stress (Montoliu et al. 1994).”
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Evaluation of globins expression in brain, heart, and lung in rats exposed to side stream cigarette smoke
Tae, B., Oliveira, K. C., da Conceição, R. R., Valenti, V. E., de Souza, J. S., Laureano‐Melo, R., Sato, M. A., Maciel, R. M. B., & Giannocco, G. (2016) · Environmental Toxicology · doi:10.1002/tox.22321 · Cited by 12
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“Enhancement of free radicals and of lipoperoxidation have been observed both after the in vitro addition of ethanol to brain homogenates and in brain homogenates of animals subjected to chronic alcohol intake (Montoliu et al. 1994).”
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Alcohol y metabolismo humano
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Transgenic Mouse Model of Ethanol as a Cofactor in HIV Disease
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C‐Phycocyanin ameliorates 2‐acetylaminofluorene induced oxidative stress and MDR1 expression in the liver of albino mice
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Red Wine, but not Port Wine, Protects Rat Hippocampal Dentate Gyrus Against Ethanol-Induced Neuronal Damage--Relevance of the Sugar Content
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Mitochondrial metabolism and neuroinflammation in the cerebral cortex and cortical synapses of rats: effect of milk intake through DNA methylation
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Authors: Montoliu, C., Vallés, S., Renau‐Piqueras, J., & Guerri, C.
Affiliations: Instituto de Investigación Sanitaria La Fe (ES)
Corresponding author: Guerri, Consuelo
ORCID: Vallés, Soraya
Guerri, Consuelo
Venue: Journal of Neurochemistry
Publisher: Wiley
Published: 1994-11
Volume: 63
Issue: 5
Pages: 1855-1862
ISSN: 0022-3042 (ISSN-L)
1471-4159
DOI: 10.1046/j.1471-4159.1994.63051855.x
OpenAlex: W1978987336
Cited by: 269
References: 0
Citations by year: 2026: 2 · 2025: 2 · 2024: 2 · 2023: 3 · 2022: 5 · 2021: 4 · 2020: 1 · 2019: 7 · 2018: 10 · 2017: 6 · 2016: 9 · 2015: 10 · 2014: 10 · 2013: 5 · 2012: 13
FWCI: 6.86
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 2944 d)
Locations: Journal of Neurochemistry (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords: chronic alcohol consumption, oxygen free radicals, lipid peroxidation, brain, cytochrome P450, CYP2E1, metyrapone, dichlorofluorescein, synaptosomes, NADPH-cytochrome c reductase, NADPH oxidation, glutathione, superoxide dismutase, catalase, ethanol neurotoxicity, brain microsomes
MeSH terms: Ethanol, Alcoholism, Animals, Brain, Brain Chemistry, Catalase, Cytochrome P-450 Enzyme System, Dose-Response Relationship, Drug, Electrophoresis, Polyacrylamide Gel, Female, Free Radicals, Glutathione, Isomerism, NADP, Oxygen, Superoxide Dismutase, Synaptosomes, Immunoblotting, Lipid Peroxidation, Rats, Wistar, Reactive Oxygen Species, Glutathione Disulfide, Rats

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Ethanol‐Induced Oxygen Radical Formation and Lipid Peroxidation in Rat Brain: Effect of Chronic Alcohol Consumption

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