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Cloning, Characterization, and Chromosomal Localization of a Human 5‐HT6 Serotonin Receptor
Open accessAbstract
Abstract: We describe the cloning and characterization of a human 5‐HT 6 serotonin receptor. The open reading frame is interrupted by two introns in positions corresponding to the third cytoplasmic loop and the third extracellular loop. The human 5‐HT 6 cDNA encodes a 440‐amino‐acid polypeptide whose sequence diverges significantly from that published for the rat 5‐HT 6 receptor. Resequencing of the rat cDNA revealed a sequencing error producing a frame shift within the open reading frame. The human 5‐HT 6 amino acid sequence is 89% similar to the corrected rat sequence. The recombinant human 5‐HT 6 receptor is positively coupled to adenylyl cyclase and has pharmacological properties similar to the rat receptor with high affinity for several typical and atypical antipsychotics, including clozapine. The receptor is expressed in several human brain regions, most prominently in the caudate nucleus. The gene for the receptor maps to the human chromosome region 1p35–p36. This localization overlaps that established for the serotonin 5‐HT 1Dα receptor, suggesting that these may be closely linked. Comparison of genomic and cDNA clones for the human 5‐HT 6 receptor also reveals an Rsa I restriction fragment length polymorphism within the coding region.
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Cited by
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Keiser, M. J., Setola, V., Irwin, J. J., Laggner, C., Abbas, A. I., Hufeisen, S. J., Jensen, N. H., Kuijer, M. B., Matos, R. C., Tran, T. B., et al. (2009) · Nature · doi:10.1038/nature08506 · Cited by 1,667
Self-citationMolecular biology of 5-HT receptors
Hannon, J., & Hoyer, D. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.03.020 · Cited by 815
Multiplicity of mechanisms of serotonin receptor signal transduction
Raymond, J. R., Mukhin, Y. V., Gelasco, A., Turner, J., Collinsworth, G., Gettys, T. W., Grewal, J. S., & Garnovskaya, M. N. (2001) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(01)00169-3 · Cited by 466
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Metadata
- Authors
- Kohen, R., Metcalf, M. A., Khan, N., Druck, T., Huebner, K., Lachowicz, J. E., Meltzer, H. Y., Sibley, D. R., Roth, B. L., & Hamblin, M. W.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 1996-01
- Volume
- 66
- Issue
- 1
- Pages
- 47-56
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W2048159519
- Cited by
- 377
- References
- 0
- FWCI
- 6.46
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Cloning, Characterization, and Chromosomal Localization of a Human 5‐HT6 Serotonin Receptor. https://app.cochat.ai/papers/10.1046/j.1471-4159.1996.66010047.x
- The paper
- Kohen, R., Metcalf, M. A., Khan, N., Druck, T., Huebner, K., Lachowicz, J. E., Meltzer, H. Y., Sibley, D. R., Roth, B. L., & Hamblin, M. W. (1996). Cloning, Characterization, and Chromosomal Localization of a Human 5‐HT6 Serotonin Receptor. Journal of Neurochemistry. https://doi.org/10.1046/j.1471-4159.1996.66010047.x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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