Cited by 288Alzheimer's disease research and treatmentsReceptor Mechanisms and SignalingNeuroscience and Neuropharmacology Research

The role of G protein-coupled receptors in the pathology of Alzheimer's disease

Thathiah, Amantha, De Strooper, Bart·2011·Nature Reviews Neuroscience

Abstract

G protein-coupled receptors (GPCRs) are involved in numerous key neurotransmitter systems in the brain that are disrupted in Alzheimer's disease (AD). GPCRs also directly influence the amyloid cascade through modulation of the α-, β- and γ-secretases, proteolysis of the amyloid precursor protein (APP), and regulation of amyloid-β degradation. Additionally, amyloid-β has been shown to perturb GPCR function. Emerging insights into the mechanistic link between GPCRs and AD highlight the potential of this class of receptors as a therapeutic target for AD.

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Crossref · 10.1038/nrn2977

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199 of 199 references verified0 citation errors · 0 not checkable

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  • GPR20 belongs to the family of the G-protein-coupled receptors, which participate in intracellular second messenger systems triggered by different hormones and neurotransmitters, and amyloid β.

    “GPR20 belongs to the family of the G-protein-coupled receptors, which participate in intracellular second messenger systems triggered by different hormones and neurotransmitters, and amyloid β.53, 54, 55”

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Authors
Thathiah, A., & De Strooper, B.
Affiliations
Vlaams Instituut voor Biotechnologie (BE)
Corresponding author
Thathiah, Amantha
Venue
Nature Reviews Neuroscience
Published
2011-01-20
Volume
12
Issue
2
Pages
73-87
ISSN
  • 1471-003X (ISSN-L)
  • 1471-0048
OpenAlex
W2077225773
Cited by
288
References
199
Citations by year
2026: 6 · 2025: 17 · 2024: 13 · 2023: 11 · 2022: 21 · 2021: 17 · 2020: 21 · 2019: 20 · 2018: 23 · 2017: 24 · 2016: 25 · 2015: 23 · 2014: 13 · 2013: 23 · 2012: 17
FWCI
2.30
Type
journal article
Language
en
Open access
closed
Locations
  • Nature reviews. Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
  • Lirias (KU Leuven) (submittedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
G protein-coupled receptors, Alzheimer's disease, amyloid-beta, amyloid hypothesis, secretases, amyloid precursor protein, amyloid beta degradation, neurotransmitter systems, therapeutic target, multi-target therapy
MeSH terms
Alzheimer Disease, Animals, Brain, Humans, Amyloid beta-Peptides, Amyloid beta-Protein Precursor, Neurotransmitter Agents, Receptors, G-Protein-Coupled, Amyloid Precursor Protein Secretases

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