Continuous Monitoring of Extracellular Glucose Concentrations in the Striatum of Freely Moving Rats with an Implanted Glucose Biosensor
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Abstract: We have used a glucose oxidase‐based sensor implanted in the striatum of freely moving rats to determine the concentration of extracellular glucose in two distinct ways. With a modification of the zero net flux method, in which different concentrations of glucose are infused through a dialysis probe glued to the biosensor, we calculated the concentration at which there was no change in glucose current by regression analysis; this gave a concentration of 0.351 ± 0.016 m M. Calculating the concentration from the basal current and the in vitro calibration of the biosensor was not significantly different from this. The basal extracellular glucose concentration determined by either method remained constant over a period of several days. Infusion of 50 µ M veratridine through the adjacent dialysis probe caused a steep decrease in glucose current as soon as the drug reached the brain in contrast to the delayed fall (7.5 min) seen with microdialysis in previous experiments from this laboratory. These results demonstrate that this biosensor provides a direct, real‐time measure of the extracellular concentration of glucose.
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Microdialysis probes consume much more glucose than electrochemical glucose sensors and may therefore underestimate biofouling effects in vivo.
“microdialysis probes consume significantly more glucose than electrochemical glucose sensors and therefore may underestimate the effects of biofouling in vivo.105”
From Biocompatible Materials for Continuous Glucose Monitoring Devices (2013) · cites this paper as [105]
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References 21 · Cited by 105
Research works printed but not linked: 1
- Morrison P. F., Bungay P. M., Hsiao J. K., Mefford I. N., Dykstra K. H., and Dedrick R. L. (1991) Quantitative microdialysis, in Microdialysis in the Neurosciences (Robinson T. E. and Justice J. B. Jr., eds), pp. 47-80. Elsevier, Amsterdam.
- Authors
- Lowry, J. P., O'Neill, R. D., Boutelle, M. G., & Fillenz, M.
- Affiliations
- University College Dublin (IE)
- King's College London (GB)
- University of Oxford (GB)
- Corresponding author
- Fillenz, Marianne
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 1998-01
- Volume
- 70
- Issue
- 1
- Pages
- 391-396
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W1976989422
- Cited by
- 105
- References
- 21
- Citations by year
- 2026: 1 · 2022: 1 · 2020: 1 · 2019: 1 · 2018: 3 · 2017: 5 · 2016: 4 · 2015: 6 · 2014: 4 · 2013: 9 · 2012: 4
- FWCI
- 8.78
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neurochemistry (publishedVersion)
- PubMed (publishedVersion)
- Maynooth University ePrints and eTheses Archive (Maynooth University) (acceptedVersion)
- Topics
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Electrochemical sensors and biosensors
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Physical Sciences › Chemical Engineering › Bioengineering › Analytical Chemistry and Sensors
- Keywords
- extracellular glucose, glucose biosensor, glucose oxidase, striatum, freely moving rats, veratridine, microdialysis, real-time glucose monitoring
- MeSH terms
- Animals, Corpus Striatum, Extracellular Space, Glucose, Male, Monitoring, Physiologic, Osmolar Concentration, Veratridine, Biosensing Techniques, Rats, Sprague-Dawley, Prostheses and Implants, Rats
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