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Am tyr 1: Characterization of a Gene from Honeybee (Apis mellifera) Brain Encoding a Functional Tyramine Receptor
Abstract
Abstract: Biogenic amine receptors are involved in the regulation and modulation of various physiological and behavioral processes in both vertebrates and invertebrates. We have cloned a member of this gene family from the CNS of the honeybee, Apis mellifera. The deduced amino acid sequence is homologous to tyramine receptors cloned from Locusta migratoria and Drosophila melanogaster as well as to an octopamine receptor cloned from Heliothis virescens. Functional properties of the honeybee receptor were studied in stably transfected human embryonic kidney 293 cells. Tyramine reduced forskolin‐induced cyclic AMP production in a dose‐dependent manner with an EC 50 of ∼130 n M. A similar effect of tyramine was observed in membrane homogenates of honeybee brains. Octopamine also reduced cyclic AMP production in the transfected cell line but was both less potent (EC 50 of ∼3 μ M) and less efficacious than tyramine. Receptor‐encoding mRNA has a widespread distribution in the brain and subesophageal ganglion of the honeybee, suggesting that this tyramine receptor is involved in sensory signal processing as well as in higher‐order brain functions.
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Cited by
Tyramine and octopamine: ruling behavior and metabolism
Roeder, T. (2005) · Annual Review of Entomology · doi:10.1146/annurev.ento.50.071803.130404 · Cited by 711
Tyramine Functions Independently of Octopamine in the Caenorhabditis elegans Nervous System
Alkema, M. J., Hunter-Ensor, M., Ringstad, N., & Horvitz, H. R. (2005) · Neuron · doi:10.1016/j.neuron.2005.02.024 · Cited by 398
Blenau, W., & Baumann, A. (2001) · Archives of Insect Biochemistry and Physiology · doi:10.1002/arch.1055 · Cited by 383
Self-citationTrace amine-associated receptors and their ligands
Zucchi, R., Chiellini, G., Scanlan, T. S., & Grandy, D. K. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706948 · Cited by 314
Metadata
- Authors
- Blenau, W., Balfanz, S., & Baumann, A.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 2000-03
- Volume
- 74
- Issue
- 3
- Pages
- 900-908
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W2032382791
- Cited by
- 164
- References
- 0
- FWCI
- 2.82
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Am tyr 1: Characterization of a Gene from Honeybee (Apis mellifera) Brain Encoding a Functional Tyramine Receptor. https://app.cochat.ai/papers/10.1046/j.1471-4159.2000.0740900.x
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- Blenau, W., Balfanz, S., & Baumann, A. (2000). Am tyr 1: Characterization of a Gene from Honeybee (Apis mellifera) Brain Encoding a Functional Tyramine Receptor. Journal of Neurochemistry. https://doi.org/10.1046/j.1471-4159.2000.0740900.x
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