Tyramine and octopamine: ruling behavior and metabolism

Roeder, Thomas

doi:10.1146/annurev.ento.50.071803.130404

Cited by 711Neurobiology and Insect Physiology ResearchReceptor Mechanisms and SignalingNeuroscience and Neuropharmacology Research

Tyramine and octopamine: ruling behavior and metabolism

Roeder, Thomas·2005·Annual Review of Entomology

DOI 10.1146/annurev.ento.50.071803.130404

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Abstract

Octopamine (OA) and tyramine (TA) are the invertebrate counterparts of the vertebrate adrenergic transmitters. They are decarboxylation products of the amino acid tyrosine, with TA as the biological precursor of OA. Nevertheless, both compounds are independent neurotransmitters that act through G protein-coupled receptors. OA modulates a plethora of behaviors and peripheral and sense organs, enabling the insect to respond correctly to external stimuli. Because these two phenolamines are the only biogenic amines whose physiological significance is presumably restricted to invertebrates, pharmacologists have focused their attention on the corresponding receptors, which are still believed to represent promising targets for new insecticides. Recent progress made on all levels of OA and TA research has enabled researchers to understand better the molecular events underlying the control of complex behaviors.

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Norepinephrine is important in regulating vertebrate sleep, whereas octopamine appears important in regulating sleep and several other cognitive and affective responses in flies.
“Norpineine is important in regulating vertebrate sleep (Hunsley and Palmiter, 2004), whereas octopamine, an invertebrate homolog to norepinephrine (Roeder, 2005), appears important in regulating sleep, as well as several other cognitive and affective responses in flies.”
From Biological rhythms, higher brain function, and behavior: Gaps, opportunities, and challenges (2009) · cites this paper as Roeder, 2005

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Authors: Roeder, T.
Affiliations: Philipps University of Marburg (DE)
Corresponding author: Roeder, Thomas
ORCID: Roeder, Thomas
Venue: Annual Review of Entomology
Publisher: Annual Reviews
Published: 2005-01-01
Volume: 50
Issue: 1
Pages: 447-477
ISSN: 0066-4170 (ISSN-L)
1545-4487
DOI: 10.1146/annurev.ento.50.071803.130404
OpenAlex: W2135781772
Cited by: 711
References: 105
Citations by year: 2026: 37 · 2025: 30 · 2024: 32 · 2023: 37 · 2022: 34 · 2021: 42 · 2020: 40 · 2019: 32 · 2018: 30 · 2017: 45 · 2016: 35 · 2015: 36 · 2014: 45 · 2013: 34 · 2012: 41
FWCI: 1.31
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Entomology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: octopamine, tyramine, biogenic amines, G protein-coupled receptors, insect behavior, insecticide targets, insect neurobiology
MeSH terms: Animals, Behavior, Animal, Brain, Drosophila melanogaster, Insecticides, Insecta, Neurons, Octopamine, Phylogeny, Tyramine

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Tyramine and octopamine: ruling behavior and metabolism

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