The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Autoxidation and Neurotoxicity of 6‐Hydroxydopamine in the Presence of Some Antioxidants: Potential Implication in Relation to the Pathogenesis of Parkinson's Disease
Abstract
Abstract: 6‐Hydroxydopamine (6‐OHDA) is a dopaminergic neurotoxin putatively involved in the pathogenesis of Parkinson's disease (PD). Its neurotoxicity has been related to the production of reactive oxygen species. In this study we examine the effects of the antioxidants ascorbic acid (AA), glutathione (GSH), cysteine (CySH), and N‐acetyl‐CySH (NAC) on the autoxidation and neurotoxicity of 6‐OHDA. In vitro, the autoxidation of 6‐OHDA proceeds rapidly with the formation of H 2 O 2 and with the participation of the H 2 O 2 produced in the reaction. The presence of AA induced a reduction in the consumption of O 2 during the autoxidation of 6‐OHDA and a negligible presence of the p‐quinone, which demonstrates the efficiency of AA to act as a redox cycling agent. The presence of GSH, CySH, and NAC produced a significant reduction in the autoxidation of 6‐OHDA. In vivo, the presence of sulfhydryl antioxidants protected against neuronal degeneration in the striatum, which was particularly remarkable in the case of CySH and was attributed to its capacity to remove the H 2 O 2 produced in the autoxidation of 6‐OHDA. These results corroborate the involvement of oxidative stress as the major mechanism in the neurotoxicity of 6‐OHDA and the putative role of CySH as a scavenger in relation to PD.
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Cites
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Cited by
The chemistry and biological activities of N-acetylcysteine
Samuni, Y., Goldstein, S., Dean, O. M., & Berk, M. (2013) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.04.016 · Cited by 876
The brainstem noradrenergic systems in stress, anxiety and depression
Itoi, K., & Sugimoto, N. (2010) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2010.01988.x · Cited by 207
Yamamuro, A., Yoshioka, Y., Ogita, K., & Maeda, S. (2006) · Neurochemical Research · doi:10.1007/s11064-006-9062-6 · Cited by 70
Rho kinase inhibitor fasudil reduces l‐DOPA‐induced dyskinesia in a rat model of Parkinson's disease
Lopez‐Lopez, A., Labandeira, C. M., Labandeira‐Garcia, J. L., & Muñoz, A. (2020) · British Journal of Pharmacology · doi:10.1111/bph.15275 · Cited by 40
Self-citation
Metadata
- Authors
- Soto‐Otero, R., Méndez‐Álvarez, E., Hermida‐Ameijeiras, Á., Muñoz‐Patiño, A. M., & Labandeira‐Garcia, J. L.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 2000-04
- Volume
- 74
- Issue
- 4
- Pages
- 1605-1612
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W1542569132
- Cited by
- 314
- References
- 39
- FWCI
- 6.40
- Type
- journal article
- Language
- en
- Open access
- closed
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- Soto‐Otero, R., Méndez‐Álvarez, E., Hermida‐Ameijeiras, Á., Muñoz‐Patiño, A. M., & Labandeira‐Garcia, J. L. (2000). Autoxidation and Neurotoxicity of 6‐Hydroxydopamine in the Presence of Some Antioxidants: Potential Implication in Relation to the Pathogenesis of Parkinson's Disease. Journal of Neurochemistry. https://doi.org/10.1046/j.1471-4159.2000.0741605.x
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