The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Levels, Metabolism, and Pharmacological Activity of Anandamide in CB1 Cannabinoid Receptor Knockout Mice: Evidence for Non‐CB1, Non‐CB2 Receptor‐Mediated Actions of Anandamide in Mouse Brain
Abstract
Abstract: Anandamide [arachidonylethanolamide (AEA)] appears to be an endogenous agonist of brain cannabinoid receptors (CB 1), yet some of the neurobehavioral effects of this compound in mice are unaffected by a selective CB 1 antagonist. We studied the levels, pharmacological actions, and degradation of AEA in transgenic mice lacking the CB 1 gene. We quantified AEA and the other endocannabinoid, 2‐arachidonoyl glycerol, in six brain regions and the spinal cord by isotope‐dilution liquid chromatography‐mass spectrometry. The distribution of endocannabinoids and their inactivating enzyme, fatty acid amide hydrolase, were found to overlap with CB 1 distribution only in part. In CB 1 knockout homozygotes (CB 1‐/‐), the hippocampus and, to a lesser extent, the striatum exhibited lower AEA levels as compared with wild‐type (CB 1+/+) controls. These data suggest a ligand/receptor relationship between AEA and CB 1 in these two brain regions, where tonic activation of the receptor may tightly regulate the biosynthesis of its endogenous ligand. 2‐Arachidonoyl glycerol levels and fatty acid amide hydrolase activity were unchanged in CB 1‐/‐ with respect to CB 1+/+ mice in all regions. AEA and Δ 9‐tetrahydrocannabinol (THC) were tested in CB 1‐/‐ mice for their capability of inducing analgesia and catalepsy and decreasing spontaneous activity. The effects of AEA, unlike THC, were not decreased in CB 1‐/‐ mice. AEA, but not THC, stimulated GTPγS binding in brain membranes from CB 1‐/‐ mice, and this stimulation was insensitive to CB 1 and CB 2 antagonists. We suggest that non‐CB 1, non‐CB 2 G protein‐coupled receptors might mediate in mice some of the neuro‐behavioral actions of AEA.
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Cites
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2-Arachidonoylgylcerol: A Possible Endogenous Cannabinoid Receptor Ligand in Brain
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Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide
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The Biodisposition and Metabolism of Anandamide in Mice
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Millan, M. J. (2002) · Progress in Neurobiology · doi:10.1016/s0301-0082(02)00009-6 · Cited by 3,035
International Union of Pharmacology. XXVII. Classification of Cannabinoid Receptors
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Self-citationThe endogenous cannabinoid system controls extinction of aversive memories
Marsicano, G., Wotjak, C. T., Azad, S. C., Bisogno, T., Rammes, G., Cascio, M. G., Hermann, H., Tang, J., Hofmann, C., Zieglgänsberger, W., et al. (2002) · Nature · doi:10.1038/nature00839 · Cited by 1,728
The orphan receptor GPR55 is a novel cannabinoid receptor
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Metadata
- Authors
- Di Marzo, V., Breivogel, C. S., Tao, Q., Bridgen, D. T., Razdan, R. K., Zimmer, A. M., Zimmer, A., & Martin, B. R.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 2000-12
- Volume
- 75
- Issue
- 6
- Pages
- 2434-2444
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W1830687359
- Cited by
- 393
- References
- 7
- FWCI
- 18.78
- Type
- journal article
- Language
- en
- Open access
- closed
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