The Biodisposition and Metabolism of Anandamide in Mice

Isolation and Structure of a Brain Constituent That Binds to the Cannabinoid Receptor

Devane, W. A., Hanuš, L., Breuer, A., Pertwee, R. G., Stevenson, L. A., Griffin, G., Gibson, D., Mandelbaum, A., Etinger, A., & Mechoulam, R. (1992) · Science · doi:10.1126/science.1470919 · Cited by 5,633 · see citing works

Formation and inactivation of endogenous cannabinoid anandamide in central neurons

Marzo, V. D., Fontana, A., Cadas, H., Schinelli, S., Cimino, G., Schwartz, J.-C., & Piomelli, D. (1994) · Nature · doi:10.1038/372686a0 · Cited by 1,585 · see citing works

Enzymatic synthesis and degradation of anandamide, a cannabinoid receptor agonist

Deutsch, D. G., & Chin, S. A. (1993) · Biochemical Pharmacology · doi:10.1016/0006-2952(93)90486-g · Cited by 705 · see citing works

Pharmacological activity of the cannabinoid receptor agonist, anandamide, a brain constituent

Fride, E., & Mechoulam, R. (1993) · European Journal of Pharmacology · doi:10.1016/0014-2999(93)90468-w · Cited by 448 · see citing works

Pharmacokinetics and metabolism of delta 1-tetrahydrocannabinol and other cannabinoids with emphasis on man.

Agurell, S., Halldin, M., Lindgren, J. E., Ohlsson, A., Widman, M., Gillespie, H., & Hollister, L. (1986) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06861-9 · Cited by 406 · see citing works

The pharmacological activity of anandamide, a putative endogenous cannabinoid, in mice.

Smith, P. B., Compton, D. M., Welch, S. P., Razdan, R. K., Mechoulam, R., & Martin, B. R. (1994) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)22356-4 · Cited by 394 · see citing works

Characterization of the kinetics and distribution of N-arachidonylethanolamine (anandamide) hydrolysis by rat brain

Hillard, C. J., Wilkison, D. M., Edgemond, W. S., & Campbell, W. B. (1995) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(95)00087-s · Cited by 233 · see citing works

Anandamide, an endogenous ligand of the cannabinoid receptor, induces hypomotility and hypothermia in vivo in rodents

Crawley, J. N., Corwin, R. L., Robinson, J. K., Felder, C. C., Devane, W. A., & Axelrod, J. (1993) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(93)90230-q · Cited by 231 · see citing works

Properties of rat liver N-acylethanolamine amidohydrolase.

Schmid, P. C., Zuzarte‐Augustin, M. L., & Schmid, H. H. O. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)38695-7 · Cited by 196 · see citing works

Acute and residual effects of alcohol and marijuana, alone and in combination, on mood and performance

Chait, L. D., & Perry, J. L. (1994) · Psychopharmacology · doi:10.1007/bf02245075 · Cited by 190 · see citing works

Effects of anandamide on cannabinoid receptors in rat brain membranes

Childers, S. R., Sexton, T., & Roy, M. B. (1994) · Biochemical Pharmacology · doi:10.1016/0006-2952(94)90134-1 · Cited by 176 · see citing works

Evaluation of cannabinoid receptor binding and in vivo activities for anandamide analogs.

Adams, I. B., Ryan, W. J., Singer, M. M., Thomas, B. F., Compton, D. M., Razdan, R. K., & Martin, B. R. (1995) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)09592-8 · Cited by 136 · see citing works

Catabolism of N‐Acylethanolamine Phospholipids by Dog Brain Preparations

Natarajan, V., Schmid, P. C., Reddy, P. V., & Schmid, H. H. O. (1984) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1984.tb12750.x · Cited by 121 · see citing works

Anandamide and delta 9-THC dilation of cerebral arterioles is blocked by indomethacin

Ellis, E. F., Moore, S. F., & Willoughby, K. A. (1995) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1995.269.6.h1859 · Cited by 115 · see citing works

Anandamide- and Δ9-tetrahydrocannabinol-evoked arachidonic acid mobilization and blockade by SR141716A [N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichloro-phenyl)-4-methyl-1H-Pyrazole-3-carboximide hydrochloride]

Shivachar, A. C., Martin, B. R., & Ellis, E. F. (1996) · Biochemical Pharmacology · doi:10.1016/s0006-2952(95)02248-1 · Cited by 74 · see citing works

Quantitative characterization of THC and ethanol interaction.

Esplin, B. A., & Čapek, R. (1976) · PubMed · Cited by 3 · see citing works

Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase

Cravatt, B. F., Demarest, K., Patricelli, M. P., Bracey, M. H., Giang, D. K., Martin, B. R., & Lichtman, A. H. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.161191698 · Cited by 1,310 · see citing works

Endocannabinoids: endogenous cannabinoid receptor ligands with neuromodulatory action

Marzo, V. D., Melck, D. J., Bisogno, T., & PETROCELLIS, L. D. (1998) · Trends in Neurosciences · doi:10.1016/s0166-2236(98)01283-1 · Cited by 704 · see citing works

Structure and function of fatty acid amide hydrolase

McKinney, M. K., & Cravatt, B. F. (2005) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.74.082803.133450 · Cited by 680 · see citing works

Cannabinoid receptors and their ligands

Pertwee, R. G., & Ross, R. A. (2002) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1054/plef.2001.0341 · Cited by 558 · see citing works

Enzymatic pathways that regulate endocannabinoid signaling in the nervous system

Ahn, K., McKinney, M. K., & Cravatt, B. F. (2008) · Chemical Reviews · doi:10.1021/cr0782067 · Cited by 529 · see citing works

Cardiovascular effects of marijuana and synthetic cannabinoids: the good, the bad, and the ugly

Pacher, P., Steffens, S., Haskó, G., Schindler, T. H., & Kunos, G. (2017) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2017.130 · Cited by 438 · see citing works

Endocannabinoids

Mechoulam, R., Fride, E., & Marzo, V. D. (1998) · European Journal of Pharmacology · doi:10.1016/s0014-2999(98)00649-9 · Cited by 431 · see citing works

Levels, Metabolism, and Pharmacological Activity of Anandamide in CB1 Cannabinoid Receptor Knockout Mice

Marzo, V. D., Breivogel, C. S., Tao, Q., Bridgen, D. T., Razdan, R. K., Zimmer, A. M., Zimmer, A., & Martin, B. R. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0752434.x · Cited by 389 · see citing works

Synthesis and Characterization of Potent and Selective Agonists of the Neuronal Cannabinoid Receptor (CB1)

Hillard, C. J., Manna, S., Greenberg, M. J., DiCamelli, R. F., Ross, R. A., Stevenson, L., Murphy, V. L., Pertwee, R. G., & Campbell, W. B. (1999) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38289-8 · Cited by 373 · see citing works

Cannabinoids and neuroinflammation

Walter, L. M., & Stella, N. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705667 · Cited by 334 · see citing works

‘Endocannabinoids’ and other fatty acid derivatives with cannabimimetic properties: biochemistry and possible physiopathological relevance

Marzo, V. D. (1998) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/s0005-2760(98)00042-3 · Cited by 310 · see citing works

Fatty acid amide hydrolase: an emerging therapeutic target in the endocannabinoid system

Cravatt, B. F., & Lichtman, A. H. (2003) · Current Opinion in Chemical Biology · doi:10.1016/s1367-5931(03)00079-6 · Cited by 301 · see citing works

Serum Endocannabinoid Content is Altered in Females with Depressive Disorders: A Preliminary Report

Hill, M., Miller, G., Ho, W.-S., Gorzalka, B., & Hillard, C. (2008) · Pharmacopsychiatry · doi:10.1055/s-2007-993211 · Cited by 292 · see citing works

Wired to run: exercise-induced endocannabinoid signaling in humans and cursorial mammals with implications for the ‘runner’s high’

Raichlen, D. A., Foster, A. D., Gerdeman, G. L., Seillier, A., & Giuffrida, A. (2012) · Journal of Experimental Biology · doi:10.1242/jeb.063677 · Cited by 269 · see citing works

Acute stress increases circulating anandamide and other N-acylethanolamines in healthy humans

Dlugos, A., Childs, E., Stuhr, K. L., Hillard, C. J., & de Wit, H. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.100 · Cited by 248 · see citing works

Synaptic lipid signaling

Bazan, N. G. (2003) · Journal of Lipid Research · doi:10.1194/jlr.r300013-jlr200 · Cited by 247 · see citing works

Evaluation of CB1 Receptor Knockout Mice in the Morris Water Maze

Varvel, S. A., & Lichtman, A. H. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.301.3.915 · Cited by 245 · see citing works

Integrating Endocannabinoid Signaling and Cannabinoids into the Biology and Treatment of Posttraumatic Stress Disorder

Hill, M. N., Campolongo, P., Yehuda, R., & Patel, S. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.162 · Cited by 239 · see citing works

Anandamide administration alone and after inhibition of fatty acid amide hydrolase (FAAH) increases dopamine levels in the nucleus accumbens shell in rats

Solinas, M., Justinová, Z., Goldberg, S. R., & Tanda, G. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03880.x · Cited by 229 · see citing works

Pharmacological Activity of Fatty Acid Amides Is Regulated, but Not Mediated, by Fatty Acid Amide Hydrolase in Vivo

Lichtman, A. H., Hawkins, E. G., Griffin, G., & Cravatt, B. F. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.302.1.73 · Cited by 224 · see citing works

Discovery and characterization of endogenous cannabinoids

Martin, B. R., Mechoulam, R., & Razdan, R. K. (1999) · Life Sciences · doi:10.1016/s0024-3205(99)00281-7 · Cited by 201 · see citing works

Increased Seizure Susceptibility and Proconvulsant Activity of Anandamide in Mice Lacking Fatty Acid Amide Hydrolase

Clement, A. B., Hawkins, E. G., Lichtman, A. H., & Cravatt, B. F. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-09-03916.2003 · Cited by 187 · see citing works

Evaluation of fatty acid amide hydrolase inhibition in murine models of emotionality

Naidu, P. S., Varvel, S. A., Ahn, K., Cravatt, B. F., Martin, B. R., & Lichtman, A. H. (2007) · Psychopharmacology · doi:10.1007/s00213-006-0689-4 · Cited by 184 · see citing works

Exercise-induced endocannabinoid signaling is modulated by intensity

Raichlen, D. A., Foster, A. D., Seillier, A., Giuffrida, A., & Gerdeman, G. L. (2013) · European Journal of Applied Physiology · doi:10.1007/s00421-012-2495-5 · Cited by 181 · see citing works

Critical Enzymes Involved in Endocannabinoid Metabolism

Basavarajappa, B. S. (2007) · Protein and Peptide Letters · doi:10.2174/092986607780090829 · Cited by 179 · see citing works

Quantification of endocannabinoids in biological systems by chromatography and mass spectrometry: A comprehensive review from an analytical and biological perspective

Zoerner, A. A., Gutzki, F., Bátkai, S., May, M., Rakers, C., Engeli, S., Jordan, J., & Tsikas, D. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2011.08.004 · Cited by 176 · see citing works

Neuroprotection by the Endogenous Cannabinoid Anandamide and Arvanil againstIn VivoExcitotoxicity in the Rat: Role of Vanilloid Receptors and Lipoxygenases

Veldhuis, W. B., van der Stelt, M., Wadman, M. W., van Zadelhoff, G., Maccarrone, M., Fezza, F., Veldink, G. A., Vliegenthart, J. F. G., Bär, P. R., Nicolay, K., et al. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-10-04127.2003 · Cited by 175 · see citing works

Endocannabinoids and fatty acid amides in cancer, inflammation and related disorders

PETROCELLIS, L. D., Melck, D. J., Bisogno, T., & Marzo, V. D. (2000) · Chemistry and Physics of Lipids · doi:10.1016/s0009-3084(00)00196-1 · Cited by 174 · see citing works

Inhibition of fatty acid amide hydrolase produces analgesia by multiple mechanisms

Chang, L., Luo, L., Palmer, J. A., Sutton, S. W., Wilson, S. J., Barbier, A., Breitenbucher, J. G., Chaplan, S. R., & Webb, M. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706773 · Cited by 166 · see citing works

Assessment of Anandamide Interaction with the Cannabinoid Brain Receptor: SR 141716A Antagonism Studies in Mice and Autoradiographic Analysis of Receptor Binding in Rat Brain

Adams, I. B., Compton, D. M., & Martin, B. R. (1998) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37342-2 · Cited by 164 · see citing works

Cannabinoid receptors and the regulation of bone mass

Bab, I., & Zimmer, A. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707593 · Cited by 160 · see citing works

Inhibition of fatty acid amide hydrolase produces analgesia by multiple mechanisms

Chang, L., Luo, L., Palmer, J. A., Sutton, S., Wilson, S. J., Barbier, A. J., Breitenbucher, J. G., Chaplan, S. R., & Webb, M. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706699 · Cited by 155 · see citing works

Anandamide induces apoptosis of PC‐12 cells: involvement of superoxide and caspase‐3

Sarker, K. P., Obara, S., Nakata, M., Kitajima, I., & Maruyama, I. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01425-3 · Cited by 151 · see citing works

Oxidative metabolism of anandamide

BURSTEIN, S. H., Rossetti, R. G., Yagen, B., & Zurier, R. B. (2000) · Prostaglandins & Other Lipid Mediators · doi:10.1016/s0090-6980(00)00053-8 · Cited by 145 · see citing works

Understanding the local actions of lipids in bone physiology

During, A., Penel, G., & Hardouin, P. (2015) · Progress in Lipid Research · doi:10.1016/j.plipres.2015.06.002 · Cited by 142 · see citing works

Ligand‐induced down‐regulation of the cannabinoid 1 receptor is mediated by the G‐protein‐coupled receptor‐associated sorting protein GASP1

Martini, L., Waldhoer, M., Pusch, M., Kharazia, V., Fong, J. C., Lee, J. H., Freissmuth, C., & Whistler, J. L. (2006) · The FASEB Journal · doi:10.1096/fj.06-7132com · Cited by 142 · see citing works

Cannabinoid Tolerance and Dependence

Lichtman, A. H., & Martin, B. R. (2005) · Springer eBooks · doi:10.1007/3-540-26573-2_24 · Cited by 142 · see citing works

Endocannabinoids in cognition and dependence

Lichtman, A. H., Varvel, S. A., & Martin, B. R. (2002) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1054/plef.2001.0351 · Cited by 135 · see citing works

Attenuation of nerve growth factor-induced visceral hyperalgesia via cannabinoid CB1 and CB2-like receptors

Farquhar-Smith, P. W., Jaggar, S., & Rice, A. S. C. (2002) · Pain · doi:10.1016/s0304-3959(01)00419-5 · Cited by 132 · see citing works

Formation of prostamides from anandamide in FAAH knockout mice analyzed by HPLC with tandem mass spectrometry

Weber, A., Ni, J., Ling, K.-H. J., Acheampong, A., Tang‐Liu, D. D., Burk, R. M., Cravatt, B. F., & Woodward, D. F. (2004) · Journal of Lipid Research · doi:10.1194/jlr.m300475-jlr200 · Cited by 129 · see citing works

Fatty acid amide hydrolase: biochemistry, pharmacology, and therapeutic possibilities for an enzyme hydrolyzing anandamide, 2-arachidonoylglycerol, palmitoylethanolamide, and oleamide11Abbreviations: AEA, anandamide, arachidonyl ethanolamide; PEA, palmitoylethanolamide, N-(2-hydroxyethyl) hexadecamide; FAAH, fatty acid amide hydrolase; CB, cannabinoid; PMSF, phenylmethylsulfonyl fluoride; MAFP, methyl arachidonyl fluorophosphonate; methAEA, arachidonyl-1′-hydroxy-2′-propylamide; and NSAIDs, nonsteroidal anti-inflammatory drugs.

Fowler, C. J., Jonsson, K., & Tiger, G. (2001) · Biochemical Pharmacology · doi:10.1016/s0006-2952(01)00712-2 · Cited by 129 · see citing works

Biochemistry of the Endogenous Ligands of Cannabinoid Receptors

Marzo, V. D., & Deutsch, D. G. (1998) · Neurobiology of Disease · doi:10.1006/nbdi.1998.0214 · Cited by 127 · see citing works

Hypolocomotor effects in rats of capsaicin and two long chain capsaicin homologues

Marzo, V. D., Lastres‐Becker, I., Bisogno, T., PETROCELLIS, L. D., Milone, A., Davis, J. B., & Fernández‐Ruíz, J. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)01012-3 · Cited by 126 · see citing works

The enzymatic inactivation of the fatty acid amide class of signaling lipids

Cravatt, B. F., & Lichtman, A. H. (2002) · Chemistry and Physics of Lipids · doi:10.1016/s0009-3084(02)00147-0 · Cited by 118 · see citing works

Cannabinoid Transmission and Pain Perception

Martin, B. R., & Lichtman, A. H. (1998) · Neurobiology of Disease · doi:10.1006/nbdi.1998.0218 · Cited by 117 · see citing works

Human Platelets and Polymorphonuclear Leukocytes Synthesize Oxygenated Derivatives of Arachidonylethanolamide (Anandamide): Their Affinities for Cannabinoid Receptors and Pathways of Inactivation

Edgemond, W. S., Hillard, C. J., Falck, J. R., Kearn, C. S., & Campbell, W. B. (1998) · Molecular Pharmacology · doi:10.1124/mol.54.1.180 · Cited by 116 · see citing works

Molecular Mechanism and Cannabinoid Pharmacology

Schurman, L. D., Lu, D., Kendall, D. A., Howlett, A. C., & Lichtman, A. H. (2019) · Handbook of experimental pharmacology · doi:10.1007/164_2019_298 · Cited by 102 · see citing works

Cannabinoids and the skeleton: From marijuana to reversal of bone loss

Bab, I., Zimmer, A. D., & Melamed, E. (2009) · Annals of Medicine · doi:10.1080/07853890903121025 · Cited by 101 · see citing works

Cannabinoid pharmacology: implications for additional cannabinoid receptor subtypes

Wiley, J. L., & Martin, B. R. (2002) · Chemistry and Physics of Lipids · doi:10.1016/s0009-3084(02)00146-9 · Cited by 100 · see citing works

The cannabinoid system: a role in both the homeostatic and hedonic control of eating?

Harrold, J. A., & Williams, G. (2003) · British Journal Of Nutrition · doi:10.1079/bjn2003942 · Cited by 100 · see citing works

ASK1–p38 MAPK/JNK signaling cascade mediates anandamide‐induced PC12 cell death

Sarker, K. P., Biswas, K. K., Yamakuchi, M., Lee, K., Hahiguchi, T., Kracht, M., Kitajima, I., & Maruyama, I. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01663.x · Cited by 99 · see citing works

Isotope dilution GC/MS determination of anandamide and other fatty acylethanolamides in rat blood plasma

Giuffrida, A., & Piomelli, D. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00046-5 · Cited by 92 · see citing works

Concerted Action of CB1 Cannabinoid Receptor and Deleted in Colorectal Cancer in Axon Guidance

Argaw, A., Duff, G., Zabouri, N., Cécyre, B., Chainé, N., Cherif, H., Tea, N., Lutz, B., Ptito, M., & Bouchard, J. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.4134-09.2011 · Cited by 91 · see citing works

Adrenocortical dysregulation as a major player in insulin resistance and onset of obesity

Roberge, C., Carpentier, A. C., Langlois, M., Baillargeon, J., Ardilouze, J., Maheux, P., & Gallo‐Payet, N. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00516.2007 · Cited by 87 · see citing works

Cannabinoid CB1 Receptor Agonists Produce Cerebellar Dysfunction in Mice

Patel, S., & Hillard, C. J. (2001) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)29579-3 · Cited by 87 · see citing works

The Effect of the Enzyme Inhibitor Phenylmethylsulfonyl Fluoride on the Pharmacological Effect of Anandamide in the Mouse Model of Cannabimimetic Activity

Compton, D. R., & Martin, B. R. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37121-6 · Cited by 86 · see citing works

FAAH−/− Mice Display Differential Tolerance, Dependence, and Cannabinoid Receptor Adaptation After Δ9-Tetrahydrocannabinol and Anandamide Administration

Falenski, K. W., Thorpe, A. J., Schlosburg, J. E., Cravatt, B. F., Abdullah, R. A., Smith, T. H., Selley, D. E., Lichtman, A. H., & Sim‐Selley, L. J. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.44 · Cited by 83 · see citing works

Endocannabinoid hydrolases

Ueda, N. (2002) · Prostaglandins & Other Lipid Mediators · doi:10.1016/s0090-6980(02)00053-9 · Cited by 82 · see citing works

Oleamide: A Fatty Acid Amide Signaling Molecule in the Cardiovascular System?

Hiley, C. R., & Hoi, M. P. M. (2007) · Cardiovascular Drug Reviews · doi:10.1111/j.1527-3466.2007.00004.x · Cited by 81 · see citing works

Marijuana Withdrawal Syndrome in the Animal Model

Lichtman, A. H., & Martin, B. R. (2002) · The Journal of Clinical Pharmacology · doi:10.1002/j.1552-4604.2002.tb05999.x · Cited by 78 · see citing works

( R )-Methanandamide and Δ 9 -THC as discriminative stimuli in rats: tests with the cannabinoid antagonist SR-141716 and the endogenous ligand anandamide

Järbe, T. U. C., Lamb, R. J., Lin, S., & Makriyannis, A. (2001) · Psychopharmacology · doi:10.1007/s002130100730 · Cited by 77 · see citing works

Proteins regulating the biosynthesis and inactivation of neuromodulatory fatty acid amides

Patricelli, M. P., & Cravatt, B. F. (2001) · Vitamins and hormones · doi:10.1016/s0083-6729(01)62002-8 · Cited by 73 · see citing works

Effects of SR 141716A after acute or chronic cannabinoid administration in dogs

Lichtman, A. H., Wiley, J. L., LaVecchia, K. L., Neviaser, S. T., Arthur, D. B., Wilson, D. M., & Martin, B. R. (1998) · European Journal of Pharmacology · doi:10.1016/s0014-2999(98)00558-5 · Cited by 72 · see citing works

Metabolite profiling identifies anandamide as a biomarker of nonalcoholic steatohepatitis

Kimberly, W. T., O’Sullivan, J., Nath, A. K., Keyes, M. J., Shi, X. D., Larson, M. G., Yang, Q., Long, M. T., Vasan, R. S., Peterson, R. T., et al. (2017) · JCI Insight · doi:10.1172/jci.insight.92989 · Cited by 71 · see citing works

Natural cannabinoids: Templates for drug discovery

Thakur, G. A., Duclos, R. I., & Makriyannis, A. (2005) · Life Sciences · doi:10.1016/j.lfs.2005.09.014 · Cited by 71 · see citing works

Evidence for an endocannabinoid system in the central nervous system of the leech Hirudo medicinalis

Matias, I., Bisogno, T., Melck, D. J., Vandenbulcke, F., Verger‐Bocquet, M., PETROCELLIS, L. D., Sergheraert, C., Breton, C., Marzo, V. D., & Salzet, M. (2001) · Molecular Brain Research · doi:10.1016/s0169-328x(00)00290-4 · Cited by 67 · see citing works

Intraplantar injection of anandamide inhibits mechanically-evoked responses of spinal neurones via activation of CB2 receptors in anaesthetised rats

Sokal, D. M., Elmes, S. J. R., Kendall, D. A., & Chapman, V. (2003) · Neuropharmacology · doi:10.1016/s0028-3908(03)00195-3 · Cited by 67 · see citing works

Evaluation of fatty acid amides in the carrageenan-induced paw edema model

Wise, L. E., Cannavacciulo, R., Cravatt, B. F., Martin, B. R., & Lichtman, A. H. (2007) · Neuropharmacology · doi:10.1016/j.neuropharm.2007.06.003 · Cited by 66 · see citing works

Cannabis

Wiley, J. L. (1999) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(99)00059-3 · Cited by 64 · see citing works

Stimulation of pulmonary vagal C‐fibres by anandamide in anaesthetized rats: role of vanilloid type 1 receptors

Lin, Y. S., & Lee, L. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2001.013290 · Cited by 54 · see citing works

Distribution and characterization of anandamide amidohydrolase in mouse brain and liver

Watanabe, K., Ogi, H., Nakamura, S., Kayano, Y., Matsunaga, T., Yoshimura, H., & Yamamoto, I. (1998) · Life Sciences · doi:10.1016/s0024-3205(98)00052-6 · Cited by 53 · see citing works

Endocannabinoids decrease neuropathic pain-related behavior in mice through the activation of one or both peripheral CB1 and CB2 receptors

Desroches, J., Charron, S., Bouchard, J., & Beaulieu, P. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.10.006 · Cited by 51 · see citing works

Fatty Acid Amide Hydrolase (–/–) Mice Exhibit an Increased Sensitivity to the Disruptive Effects of Anandamide or Oleamide in a Working Memory Water Maze Task

Varvel, S. A., Cravatt, B. F., Engram, A. E., & Lichtman, A. H. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.095059 · Cited by 47 · see citing works

Cannabinoid Properties of Methylfluorophosphonate Analogs

Martin, B. R., Beletskaya, I., Patrick, G., Jefferson, R. G., Winckler, R., Deutsch, D. G., Marzo, V. D., Dasse, O. A., Mahadevan, A., & Razdan, R. K. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)39191-8 · Cited by 46 · see citing works

Anandamide and its metabolites what are their roles in the kidney

Ritter, J. K. (2016) · Frontiers in Bioscience-Scholar · doi:10.2741/s461 · Cited by 44 · see citing works

Vagal anandamide signaling via cannabinoid receptor 1 contributes to luminal 5-HT modulation of visceral nociception in rats

Feng, C.-C., Yan, X.-J., Chen, X., Wang, E.-M., Liu, Q. H., Zhang, L., Chen, J., Fang, J., & Chen, S. (2014) · Pain · doi:10.1016/j.pain.2014.05.005 · Cited by 41 · see citing works

Aryl Piperazinyl Ureas as Inhibitors of Fatty Acid Amide Hydrolase (FAAH) in Rat, Dog, and Primate

Keith, J. M., Apodaca, R. L., Tichenor, M. S., Xiao, W., Jones, W., Pierce, J. M., Seierstad, M. J., Palmer, J. A., Webb, M., Karbarz, M. J., et al. (2012) · ACS Medicinal Chemistry Letters · doi:10.1021/ml300186g · Cited by 40 · see citing works

Assessment of anandamide's pharmacological effects in mice deficient of both fatty acid amide hydrolase and cannabinoid CB1 receptors

Wise, L. E., Shelton, C. C., Cravatt, B. F., Martin, B. R., & Lichtman, A. H. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.11.002 · Cited by 40 · see citing works

Comparisons of Δ9-Tetrahydrocannabinol and Anandamide on a Battery of Cognition-Related Behavior in Nonhuman Primates

Kangas, B. D., Leonard, M. Z., Shukla, V., Alapafuja, S. O., Nikas, S. P., Makriyannis, A., & Bergman, J. (2016) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.115.228189 · Cited by 39 · see citing works

Novel associations between FAAH genetic variants and postoperative central opioid-related adverse effects

Sadhasivam, S., Zhang, X., Chidambaran, V., Mavi, J., Pilipenko, V. V., Baye, T. M., Meller, J., Kaufman, K. M., Martin, L. J., & McAuliffe, J. J. (2015) · The Pharmacogenomics Journal · doi:10.1038/tpj.2014.79 · Cited by 36 · see citing works

In vivo pharmacology of endocannabinoids and their metabolic inhibitors: Therapeutic implications in Parkinson's disease and abuse liability

Giuffrida, A., & McMahon, L. R. (2009) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2009.05.004 · Cited by 35 · see citing works

The cannabinoid receptor antagonist SR-141716 does not readily antagonize open-field effects induced by the cannabinoid receptor agonist (R)-methanandamide in rats

Järbe, T. U. C., DiPatrizio, N. V., Li, C., & Makriyannis, A. (2003) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(03)00168-0 · Cited by 35 · see citing works

Sensitive determination of anandamide in rat brain utilizing a coupled-column HPLC with fluorimetric detection

Arai, Y., Fukushima, T., Shirao, M., Yang, X., & Imai, K. (2000) · Biomedical Chromatography · doi:10.1002/(sici)1099-0801(200004)14:2 · Cited by 32 · see citing works

Evaluation of the role of the arachidonic acid cascade in anandamide's in vivo effects in mice

Wiley, J. L., Razdan, R. K., & Martin, B. R. (2006) · Life Sciences · doi:10.1016/j.lfs.2006.08.017 · Cited by 32 · see citing works

Tolerance and cross-tolerance to cannabinoids in mice: schedule-controlled responding and hypothermia

Singh, H., Schulze, D. R., & McMahon, L. R. (2011) · Psychopharmacology · doi:10.1007/s00213-010-2162-7 · Cited by 28 · see citing works

Endocannabinoids, metabolic regulation, and the role of diet

Carr, T. P., Jesch, E. D., & Brown, A. W. (2008) · Nutrition Research · doi:10.1016/j.nutres.2008.08.003 · Cited by 28 · see citing works

Regulation of Skeletal Remodeling by the Endocannabinoid System

Bab, I. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1402.014 · Cited by 27 · see citing works

Anandamide inhibits the DOI-induced head-twitch response in mice

Egashira, N., Mishima, K., Uchida, T., Hasebe, N., Nagai, H., Mizuki, A., Iwasaki, K., ISHII, H., Nishimura, R., Shoyama, Y., et al. (2004) · Psychopharmacology · doi:10.1007/s00213-003-1611-y · Cited by 27 · see citing works

Ex Vivo Imaging of Fatty Acid Amide Hydrolase Activity and Its Inhibition in the Mouse Brain

Glaser, S. T., Gatley, S. J., & Gifford, A. N. (2006) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.094748 · Cited by 26 · see citing works

Fatty acid amide hydrolase inhibition enhances the anti-allodynic actions of endocannabinoids in a model of acute pain adapted for the mouse

Palmer, J. A., Higuera, E. S., Chang, L., & Chaplan, S. R. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.04.047 · Cited by 26 · see citing works

Using Cannabis to Treat Cancer-Related Pain

Byars, T., Theisen, E., & Bolton, D. L. (2019) · Seminars in Oncology Nursing · doi:10.1016/j.soncn.2019.04.012 · Cited by 25 · see citing works

Retrograde endocannabinoid inhibition of goldfish retinal cones is mediated by 2-arachidonoyl glycerol

Fan, S.-F., & Yazulla, S. (2007) · Visual Neuroscience · doi:10.1017/s095252380707006x · Cited by 25 · see citing works

Anandamide down-regulates placental transporter expression through CB2 receptor-mediated inhibition of cAMP synthesis

Szilagyi, J. T., Wahler, G., Joseph, L. B., Wang, B., Rosen, T., Laskin, J. D., & Aleksunes, L. M. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.01.002 · Cited by 25 · see citing works

Dual pharmacological inhibitor of endocannabinoid degrading enzymes reduces depressive-like behavior in female rats

Dong, B., Shilpa, B. M., Shah, R., Goyal, A., Xie, S., Bakalian, M. J., Suckow, R. F., Cooper, T. B., Mann, J. J., Arango, V., et al. (2019) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2019.10.010 · Cited by 24 · see citing works

Synergistic combinations of the dual enkephalinase inhibitor PL265 given orally with various analgesic compounds acting on different targets, in a murine model of cancer-induced bone pain

González‐Rodríguez, S., Poras, H., Menéndez, L., Lastra, A., Ouimet, T., Fournié‐Zaluski, M., Roques, B. P., & Baamonde, A. (2016) · Scandinavian Journal of Pain · doi:10.1016/j.sjpain.2016.09.011 · Cited by 24 · see citing works

The Effect of Anandamide on Uterine Nitric Oxide Synthase Activity Depends on the Presence of the Blastocyst

Sordelli, M. S., Beltrame, J. S., Burdet, J., Zotta, E., Pardo, R. P., Cella, M., Franchi, A. M., & Ribeiro, M. L. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018368 · Cited by 23 · see citing works

Cyclooxygenase-2 prostaglandins mediate anandamide-inhibitory action on nitric oxide synthase activity in the receptive rat uterus

Sordelli, M. S., Beltrame, J. S., Cella, M., Franchi, A. M., & Ribeiro, M. L. (2012) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2012.04.034 · Cited by 23 · see citing works

N-Linoleyltyrosine Protects against Transient Cerebral Ischemia in Gerbil via CB2 Receptor Involvement in PI3K/Akt Signaling Pathway

Cheng, L., Li, J., Zhou, Y. M., Zheng, Q., Ming, X., & Liu, S. (2019) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b19-00394 · Cited by 22 · see citing works

Exo- and Endo-cannabinoids in Depressive and Suicidal Behaviors

Thippaiah, S. M., Iyengar, S. S., & Vinod, K. Y. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.636228 · Cited by 21 · see citing works

Effect of Anandamide on Cytosolic Ca2+ Levels and Proliferation in Canine Renal Tubular Cells

Yeh, J., Cheng, H., Huang, C., Chung, H., Chiu, H., Yang, Y., Yeh, M., Chen, W., Kao, C., Chou, C., et al. (2006) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/j.1742-7843.2006.pto_350.x · Cited by 21 · see citing works

Disposition and metabolism of anandamide in the mouse brain

(n.d.) · Digital Repository Service (Northeastern University)

Isolation and measurement of the endogenous cannabinoid receptor agonist, anandamide, in brain and peripheral tissues of human and rat

Felder, C. C., Nielsen, A., Briley, E. M., Palkovits, M., Priller, J., Axelrod, J., Nguyen, D. N., Richardson, J. M., Riggin, R. M., KOPPEL, G. A., et al. (1996) · FEBS Letters · doi:10.1016/0014-5793(96)00891-5 · Cited by 327 · see citing works

Characterization of the kinetics and distribution of N-arachidonylethanolamine (anandamide) hydrolysis by rat brain

Hillard, C. J., Wilkison, D. M., Edgemond, W. S., & Campbell, W. B. (1995) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(95)00087-s · Cited by 233 · see citing works

Brain uptake and metabolism of the endocannabinoid anandamide labeled in either the arachidonoyl or ethanolamine moiety

Hu, K., Sonti, S., Glaser, S. T., Duclos, R. I., & Gatley, S. J. (2016) · Nuclear Medicine and Biology · doi:10.1016/j.nucmedbio.2016.11.001 · Cited by 6 · see citing works

Microsomal cytochrome P450-mediated liver and brain anandamide metabolism

Bornheim, L. M., Kim, K. Y., Chen, B., & Correia, M. A. (1995) · Biochemical Pharmacology · doi:10.1016/0006-2952(95)00177-2 · Cited by 68 · see citing works