The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Antioxidant activity related to copper binding of native prion protein
Abstract
We have developed a method to affinity‐purify mouse prion protein (PrP c) from mouse brain and cultured cells. PrP c from mouse brain bound three copper atoms; PrP c from cultured cells bound between one and four copper atoms depending on the availability of copper in the culture medium. Purified PrP c exhibited antioxidant activity, as determined by spectrophotometric assay. Incubation of PrP c with the neurotoxic peptide, PrP106‐126, inactivated the superoxide dismutase‐like activity. Culture experiments showed that PrP c protects cells against oxidative stress relative to the amount of copper it binds. These results suggest that PrP c is a copper‐binding protein which can incorporate varying amounts of copper and exhibit protective antioxidant activity.
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Citations
Cites
Role of microglia in neuronal cell death in prion disease
Giese, A., Brown, D. R., Groschup, M. H., Feldmann, C., Haist, I., & Kretzschmar, H. A. (1998) · Brain Pathology · doi:10.1111/j.1750-3639.1998.tb00167.x · Cited by 239
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Cited by
Metals in Neurobiology: Probing Their Chemistry and Biology with Molecular Imaging
Que, E. L., Domaille, D. W., & Chang, C. J. (2008) · Chemical Reviews · doi:10.1021/cr078203u · Cited by 2,061
Gaggelli, E., Kozlowski, H., Valensin, D., & Valensin, G. (2006) · Chemical Reviews · doi:10.1021/cr040410w · Cited by 1,729
Physiology of the prion protein
Linden, R., Martins, V. R., Prado, M. A. M., Cammarota, M., Izquierdo, I., & Brentani, R. R. (2008) · Physiological Reviews · doi:10.1152/physrev.00007.2007 · Cited by 617
Butterfield, D. A., & Kanski, J. (2001) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(01)00249-4 · Cited by 419
The biological function of the cellular prion protein: an update
Wulf, M.-A., Senatore, A., & Aguzzi, A. (2017) · BMC Biology · doi:10.1186/s12915-017-0375-5 · Cited by 265
Metadata
- Authors
- Brown, D. R., Clive, C., & Haswell, S. J.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 2001-01
- Volume
- 76
- Issue
- 1
- Pages
- 69-76
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W1576911364
- Cited by
- 232
- References
- 1
- FWCI
- 7.60
- Type
- journal article
- Language
- en
- Open access
- closed
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- Brown, D. R., Clive, C., & Haswell, S. J. (2001). Antioxidant activity related to copper binding of native prion protein. Journal of Neurochemistry. https://doi.org/10.1046/j.1471-4159.2001.00009.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
