The DOI matches its Crossref record; 146 of the 146 references it cites were found in a registry or an index.
The biological function of the cellular prion protein: an update
Open accessAbstract
The misfolding of the cellular prion protein (PrP C ) causes fatal neurodegenerative diseases. Yet PrP C is highly conserved in mammals, suggesting that it exerts beneficial functions preventing its evolutionary elimination. Ablation of PrP C in mice results in well-defined structural and functional alterations in the peripheral nervous system. Many additional phenotypes were ascribed to the lack of PrP C , but some of these were found to arise from genetic artifacts of the underlying mouse models. Here, we revisit the proposed physiological roles of PrP C in the central and peripheral nervous systems and highlight the need for their critical reassessment using new, rigorously controlled animal models.
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Cites
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Self-citationNormal development and behaviour of mice lacking the neuronal cell-surface PrP protein
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A cellular gene encodes scrapie PrP 27-30 protein
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Cited by
Glutamatergic synaptic plasticity and dysfunction in Alzheimer disease: Emerging mechanisms
Benarroch, E. E. (2018) · Neurology · doi:10.1212/wnl.0000000000005807 · Cited by 115
(2019) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2019.08.002 · Cited by 78
Cellular Prion Protein (PrPc): Putative Interacting Partners and Consequences of the Interaction
Miranzadeh Mahabadi, H., & Taghibiglou, C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197058 · Cited by 52
Navarro-Gómez, N., Valdes-Gonzalez, M., Garrido-Suárez, B. B., & Garrido, G. (2023) · The Journal of Prevention of Alzheimer's Disease · doi:10.14283/jpad.2023.2 · Cited by 7
Metadata
- Authors
- Wulf, M.-A., Senatore, A., & Aguzzi, A.
- Venue
- BMC Biology
- Published
- 2017-05-02
- Volume
- 15
- Issue
- 1
- Pages
- 34-34
- ISSN
- 1741-7007 (ISSN-L)
- OpenAlex
- W2611707378
- Cited by
- 265
- References
- 146
- FWCI
- 11.16
- Type
- journal article
- Language
- en
- Open access
- gold
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- Wulf, M.-A., Senatore, A., & Aguzzi, A. (2017). The biological function of the cellular prion protein: an update. BMC Biology. https://doi.org/10.1186/s12915-017-0375-5
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
