The DOI matches its Crossref record; 53 of the 54 references it cites were found in a registry or an index.
Proinflammatory cytokines promote glial heme oxygenase-1 expression and mitochondrial iron deposition: implications for multiple sclerosis
Abstract
Proinflammatory cytokines, pathological iron deposition, and oxidative stress have been implicated in the pathogenesis of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). HO-1 mRNA levels and mitochondrial uptake of [(55)Fe]Cl(3)-derived iron were measured in rat astroglial cultures exposed to interleukin-1beta (IL-1beta) or tumor necrosis factor-alpha (TNF-alpha) alone or in combination with the heme oxygenase-1 (HO-1) inhibitors, tin mesoporphyrin (SnMP) or dexamthasone (DEX), or interferon beta1b (INF-beta). HO-1 expression in astrocytes was evaluated by immunohistochemical staining of spinal cord tissue derived from MS and control subjects. IL-1beta or TNF-alpha promoted sequestration of non-transferrin-derived (55)Fe by astroglial mitochondria. HO-1 inhibitors, mitochondrial permeability transition pore (MTP) blockers and antioxidants significantly attenuated cytokine-related mitochondrial iron sequestration in these cells. IFN-beta decreased HO-1 expression and mitochondrial iron sequestration in IL-1beta- and TNF-alpha-challenged astroglia. The percentage of astrocytes coexpressing HO-1 in affected spinal cord from MS patients (57.3% +/- 12.8%) was significantly greater (p < 0.05) than in normal spinal cord derived from controls subjects (15.4% +/- 8.4%). HO-1 is over-expressed in MS spinal cord astroglia and may promote mitochondrial iron deposition in MS plaques. In MS, IFN-beta may attenuate glial HO-1 gene induction and aberrant mitochondrial iron deposition accruing from exposure to proinflammatory cytokines.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Incubation with interferon β reverted the cytokine-dependent induction of HO-1 and the subsequent incorporation of iron into mitochondria.162”
From The role of iron in brain ageing and neurodegenerative disorders (2014) · cites this paper as [162]
In the citing paper
“Increased HO-1 expression promoted the sequestration of non-transferrin iron into the astroglial mitochondrial compartment, as assayed by 55Fe incorporation.”
From The role of iron in brain ageing and neurodegenerative disorders (2014) · cites this paper as [162]
In the citing paper
“In-vitro studies of rat astroglial cultures showed that proinflammatory cytokines (ie, interleukin 1β and tumour necrosis factor α) increased HO-1 expression after 6 days of incubation.”
From The role of iron in brain ageing and neurodegenerative disorders (2014) · cites this paper as [162]
Citations
Cites
Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction
Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1006/abio.1987.9999 · Cited by 65,515
A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity
Feinberg, A. P., & Vogelstein, B. (1983) · Analytical Biochemistry · doi:10.1016/0003-2697(83)90418-9 · Cited by 24,512
Church, G. M., & Gilbert, W. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.7.1991 · Cited by 8,213
A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity
(1984) · Analytical Biochemistry · doi:10.1016/0003-2697(84)90381-6 · Cited by 4,952
Receptor-mediated endocytosis of transferrin in K562 cells.
Klausner, R. D., van Renswoude, J., Ashwell, G., Kempf, C., Schechter, A. N., Dean, A., & Bridges, K. R. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)32481-5 · Cited by 563
(1994) · Toxicology and Industrial Health · doi:10.1177/074823379401000603 · Cited by 501
Bernardi, P. (1996) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(96)00041-2 · Cited by 412
The small heat-shock protein αB-crystallin as candidate autoantigen in multiple sclerosis
van Noort, J. M., van Sechel, A. C., Bajramovic, J. J., Ouagmiri, M. E., Polman, C. H., Lassmann, H., & Ravid, R. (1995) · Nature · doi:10.1038/375798a0 · Cited by 402
Expression of heme oxygenase‐1 in the senescent and alzheimer‐diseased brain
Schipper, H. M., Cissé, S., & Stopa, E. G. (1995) · Annals of Neurology · doi:10.1002/ana.410370609 · Cited by 353
Self-citationInduction of Haem Oxygenase as a Defence Against Oxidative Stress
Stocker, R. (1990) · Free Radical Research Communications · doi:10.3109/10715769009148577 · Cited by 323
Research works printed but not linked: 3
- 10.1016/0003-2697(87)90021-2 · DOI
- Paty D. W., 1998, Multiple Sclerosis, 427
- Trapp B. D., 1995, Cellular mechanisms of demyelination in multiple sclerosis brains, J. Neurochem., 64
Cited by
Sorted by citations
Items 101–128 of 128
Schipper, H. M., Arnold, D. L., Grand’Maison, F., Melmed, C., Moore, F. G. A., Levental, M., Su, H., Constantin, M., Stril, J.-L., & Godin, J. (2015) · Clinical Neuropharmacology · doi:10.1097/wnf.0000000000000090 · Cited by 12
Self-citationReeve, V. E., & Domanski, D. (2003) · British Journal of Dermatology · doi:10.1046/j.1365-2133.2003.05345.x · Cited by 11
Inder, T. E., & Volpe, J. J. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-42876-7.00013-2 · Cited by 9
Litvinenko, I., Вячеславович, К. И., & Trufanov, A. G. (2018) · Bulletin of the Russian Military Medical Academy · doi:10.32863/1682-7392-2018-3-63-68-77 · Cited by 7
Chakrabarty, A., Fleming, K., Marquis, J. G., & LeVine, S. M. (2005) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2004.11.010 · Cited by 8
Multiple sclerosis and oxidative stress—a clinical perspective
Kostić, M. S., Rajković, J., Floranović, M. P., Dimov, I., & Pavlovic, D. D. (2013) · Neurochemical Journal · doi:10.1134/s1819712412040083 · Cited by 8
Protective Role of High-Density Lipoprotein in Multiple Sclerosis
Damiza-Detmer, A., Pawelczyk, M., & Glabinski, A. R. (2024) · Antioxidants · doi:10.3390/antiox13111276 · Cited by 7
Dysregulation of a Heme Oxygenase–Synuclein Axis in Parkinson Disease
Cressatti, M., & Schipper, H. M. (2022) · NeuroSci · doi:10.3390/neurosci3020020 · Cited by 7
Self-citationSerum inflammatory cytokines comparison in gastric cancer therapy
Zhang, L., Ren, L., Shan, K., Guo, X., Wang, J., Cui, B., & An, J. (2019) · Open Medicine · doi:10.1515/med-2019-0027 · Cited by 6
Richter‐Landsberg, C. (2009) · Springer eBooks · doi:10.1007/978-0-387-39954-6_1 · Cited by 5
Oxidative Stress in Multiple Sclerosis Pathology and Therapeutic Potential of Nrf2 Activation
de Vries, H. E., Schreibelt, G., & van Horssen, J. (2010) · Humana Press eBooks · doi:10.1007/978-1-60327-514-9_5 · Cited by 5
Air pollution as a contributing factor of relapses and cases of multiplesclerosis
Zhukovsky, C., Bind, M., Boström, I., & Landtblom, A. (2020) · Health Risk Analysis · doi:10.21668/health.risk/2020.3.20 · Cited by 5
Gas Mediators in the Nervous System: Nitric Oxide, Hydrogen Sulfide and Carbon Monoxide
NOMENOĞLU, T., & Demirel-Yılmaz, E. (2017) · Turkiye Klinikleri Journal of Neurology · doi:10.5336/neuro.2017-58770 · Cited by 4
Heme Oxygenase-1 and Alzheimer Disease
Mawal, Y. R., Berlin, D., Kravitz, S., & Schipper, H. M. (2002) · Springer eBooks · doi:10.1007/978-1-4615-0741-3_12 · Cited by 4
Self-citationRole of Heme Catabolism in Neurodegenerative Diseases
Takeda, A., Itoyama, Y., Kimpara, T., Kutty, R. K., Abraham, N. G., Dwyer, B. E., Petersen, R. B., Perry, G. L., & Smith, M. A. (2002) · Springer eBooks · doi:10.1007/978-1-4615-0741-3_11 · Cited by 3
Pathogenesis of Alzheimer's disease and the role of heme oxygenase: new perspectives and hypothesis.
Celec, P., & Príhodová, M. (2003) · PubMed · Cited by 3
Heme oxygenase-1 in blood and saliva during acute psychosis: A pilot study
Bertrand, T., Tavitian, A., Galindez, J. M., Kothari, V., Mohit, S., Galindez, C., Liberman, A., Glass, J., Velly, A. M., Gornitsky, M., et al. (2021) · Psychiatry Research · doi:10.1016/j.psychres.2021.113857 · Cited by 2
Self-citationSharkus, R., Thakkar, R., Kolson, D. L., & Constantinescu, C. S. (2023) · Biomedicines · doi:10.3390/biomedicines11051387 · Cited by 3
Pathophysiology: General Principles
Gunn, A. J., Davidson, J. O., Inder, T. E., & Volpe, J. J. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-10513-5.00016-4 · Cited by 2
Transferrin induces interleukin-18 expression in chronic myeloid leukemia cell line, K-562
Park, S., Kim, T. S., Kim, C., Kim, S., Bang, S. I., Park, H., & Cho, D.-H. (2008) · Leukemia Research · doi:10.1016/j.leukres.2008.08.001 · Cited by 1
Glial heme oxygenase-1 in CNSinjury and disease
Schipper, H. M. (2003) · Advances in molecular and cell biology · doi:10.1016/s1569-2558(03)31038-0 · Cited by 1
Self-citationBrain Iron Deposition in Aging and Disease: Role of HO-1
Schipper, H. M. (2009) · Humana Press eBooks · doi:10.1007/978-1-59745-462-9_7 · Cited by 1
Self-citationHEME OXYGENASE-l AND ALZHEIMER DISEASE
Mawal, Y. R., Berlin, D., Kravitz, S., Schipper, H. M., Mortimer, S., & Davis, B. J. (2002) · Cited by 1
Self-citationCrowley, H., & Huber, B. T. (2010) · doi:10.1002/9780470688618.taw0118
Neuroaxonale Schädigung in experimentellen Modellen der multiplen Sklerose
Escher, A. (2008) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-1328
Asiaei, S., Nasiri, N., Ravari, M. P., Shahmoradi, D., Mohamadbagher, M., Jarrahi, F., Jafari, S. K., & Azarbayjani, M. A. (2023) · Sport Sciences for Health · doi:10.1007/s11332-023-01116-1
Behavioral and histological assessment of a novel treatment of neuroHIV in humanized micePreprint
Levine, A. J., Thadani, C., Soontornniyomkij, V., López‐Aranda, M. F., García‐Mesa, Y., Kitchen, S. G., Rezek, V. K., Silva, A. J., & Kolson, D. L. (2023) · Research Square · doi:10.21203/rs.3.rs-3678629/v1
Yin, G. Y., Zhang, J. Q., Xie, Z. L., Jin, Y. X., Wang, Y., & Qian, F. H. (2025) · Canadian Respiratory Journal · doi:10.1155/carj/9976065
Metadata
- Authors
- Mehindate, K., Sahlas, D. J., Frankel, D., Mawal, Y., Liberman, A., Corcos, J., Dion, S., & Schipper, H. M.
- Affiliations
- Jewish General Hospital (CA)
- McGill University (CA)
- Corresponding author
- Schipper, H. M.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 2001-06
- Volume
- 77
- Issue
- 5
- Pages
- 1386-1395
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W1902487112
- Cited by
- 129
- References
- 54
- Citations by year
- 2025: 1 · 2024: 4 · 2023: 5 · 2022: 1 · 2021: 1 · 2020: 4 · 2019: 2 · 2018: 3 · 2017: 7 · 2016: 2 · 2015: 5 · 2014: 7 · 2013: 3 · 2012: 3
- FWCI
- 2.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neurochemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Fonds de Recherche du Québec - Santé
- Medical Research Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heme Oxygenase-1 and Carbon Monoxide
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Keywords
- heme oxygenase-1, multiple sclerosis, inflammatory cytokines, IL-1β, TNF-α, astrocytes, iron sequestration, interferon-beta, experimental autoimmune encephalomyelitis, oxidative stress, mitochondrial permeability transition pore, tin mesoporphyrin, dexamethasone
- MeSH terms
- Animals, Cells, Cultured, Chlorides, Encephalomyelitis, Autoimmune, Experimental, Female, Ferric Compounds, Heme Oxygenase (Decyclizing), Humans, Immunohistochemistry, Interleukin-1, Iron, Iron Radioisotopes, Mitochondria, Multiple Sclerosis, Neuroglia, RNA, Messenger, Spinal Cord, Subcellular Fractions, Transferrin, Tumor Necrosis Factor-alpha, Blotting, Northern, Cytokines, Rats, Sprague-Dawley, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
