Prominent Narp expression in projection pathways and terminal fields
Abstract
Narp (neuronal activity regulated pentraxin) is a secreted immediate early gene product that is induced by synaptic activity. Recent studies have indicated that Narp may be an extracellular aggregating factor for AMPA receptors. Immunohistochemical studies have revealed prominent expression of Narp in the mossy fiber pathway of the dentate gyrus, suggesting it may be released pre‐synaptically. However, invitro studies using recombinant Narp indicate that Narp may act when expressed by either pre‐ or post‐synaptic elements. To help define Narp's mode of action, we have examined its localization in the habenula‐interpeduncular pathway which also displays robust Narp expression. Focusing on this pathway as well as hippocampal and cortical Narp expression, we found prominent Narp staining in projection pathways and terminal fields. In contrast, Narp expression in dendrites was minimal in these neuronal populations. These findings indicate that, under physiological conditions, Narp is targeted to the synapse from pre‐ rather than post‐synaptic elements. Our results also suggest that future studies focusing on these projection pathways that express high levels of Narp, in vivo, may help to understand the regulation and function of endogenous Narp.
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Under physiological conditions, NPTX2 is mainly secreted from the pre-synaptic terminal into the synapses.
“Under physiological conditions, NPTX2 is mainly secreted from the pre-synaptic terminal into the synapses (Chang et al. 2010; Reti et al. 2002).”
From Neuronal pentraxins as biomarkers of synaptic activity: from physiological functions to pathological changes in neurodegeneration (2022) · cites this paper as Reti et al. 2002
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- Authors
- Reti, I. M., Reddy, R., Worley, P. F., & Baraban, J. M.
- Affiliations
- Johns Hopkins University (US)
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 2002-08
- Volume
- 82
- Issue
- 4
- Pages
- 935-944
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W1528564858
- Cited by
- 42
- References
- 20
- Citations by year
- 2026: 1 · 2022: 1 · 2021: 3 · 2020: 1 · 2017: 1 · 2015: 2 · 2014: 2 · 2013: 3 · 2012: 1
- FWCI
- 1.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neurochemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Johns Hopkins University
- National Institutes of Health (5k20mh001153-05, 5k02da000358-02)
- National Institute of Mental Health (MH-01153)
- National Institute on Drug Abuse (DA140063, DA-00358, DA.00266)
- National Institute of Neurological Disorders and Stroke (NSN39156)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Immunology and Microbiology › Immunology › Biomarkers in Disease Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- NARP, immediate early genes, synaptic activity, mossy fiber pathway, dentate gyrus, terminal fields, hippocampus, cerebral cortex, dendrites
- MeSH terms
- Pentraxins, Animals, C-Reactive Protein, Cerebral Cortex, Dendrites, Hippocampus, Immunohistochemistry, Male, Mesencephalon, Nerve Tissue Proteins, Neural Pathways, Neurons, RNA, Messenger, Immunoblotting, Rats, Sprague-Dawley, In Situ Hybridization, Ventral Tegmental Area, Presynaptic Terminals, Habenula, Mossy Fibers, Hippocampal, Rats
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