The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Membrane properties of rat embryonic multipotent neural stem cells
Open accessAbstract
We have characterized several potential stem cell markers and defined the membrane properties of rat fetal (E10.5) neural stem cells (NSC) by immunocytochemistry, electrophysiology and microarray analysis. Immunocytochemical analysis demonstrates specificity of expression of Sox1, ABCG2/Bcrp1, and shows that nucleostemin labels both progenitor and stem cell populations. NSCs, like hematopoietic stem cells, express high levels of aldehyde dehydrogenase (ALDH) as assessed by Aldefluor labeling. Microarray analysis of 96 transporters and channels showed that Glucose transporter 1 (Glut1/Slc2a1) expression is unique to fetal NSCs or other differentiated cells. Electrophysiological examination showed that fetal NSCs respond to acetylcholine and its agonists, such as nicotine and muscarine. NSCs express low levels of tetrodotoxin (TTX) sensitive and insensitive sodium channels and calcium channels while expressing at least three kinds of potassium channels. We find that gap junction communication is mediated by connexin (Cx)43 and Cx45, and is essential for NSC survival and proliferation. Overall, our results show that fetal NSCs exhibit a unique signature that can be used to determine their location and assess their ability to respond to their environment.
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Subventricular zone astrocytes are neural stem cells in the adult mammalian brain
Doetsch, F., Caillé, I., Lim, D. A., García-Verdugo, J. M., & Alvarez-Buylla, A. (1999) · Cell · doi:10.1016/s0092-8674(00)80783-7 · Cited by 3,898
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Ma, W., Maric, D., Li, B., Hu, Q., Andreadis, J. D., Grant, G. M., Liu, Q., Shaffer, K. M., Chang, Y. H., Zhang, L., et al. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00010.x · Cited by 161
Cited by
Role of membrane potential in the regulation of cell proliferation and differentiation
Sundelacruz, S., Levin, M., & Kaplan, D. L. (2009) · Stem Cell Reviews and Reports · doi:10.1007/s12015-009-9080-2 · Cited by 489
Timper, K., Seboek, D., Eberhardt, M., Linscheid, P., Christ-Crain, M., Keller, U., Müller, B., & Zulewski, H. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.01.072 · Cited by 450
ALDH1 as a Functional Marker of Cancer Stem and Progenitor Cells
Douville, J., Beaulieu, R., & Balicki, D. (2009) · Stem Cells and Development · doi:10.1089/scd.2008.0055 · Cited by 356
Multipotent Stem Cells in Human Corneal Stroma
Du, Y., Funderburgh, M. L., Mann, M. M., SundarRaj, N., & Funderburgh, J. L. (2005) · STEM CELLS · doi:10.1634/stemcells.2004-0256 · Cited by 335
Aldehyde Dehydrogenases: Not Just Markers, but Functional Regulators of Stem Cells
Vassalli, G. (2019) · Stem Cells International · doi:10.1155/2019/3904645 · Cited by 300
Metadata
- Authors
- Cai, J., Cheng, A., Luo, Y., Lu, C., Mattson, M. P., Rao, M. S., & Furukawa, K.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 2003-11-28
- Volume
- 88
- Issue
- 1
- Pages
- 212-226
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W1525816166
- Cited by
- 176
- References
- 3
- FWCI
- 3.12
- Type
- journal article
- Language
- en
- Open access
- bronze
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