The DOI matches its Crossref record; 42 of the 44 references it cites were found in a registry or an index.
The TCR δ Repertoire in Normal Human Skin is Restricted and Distinct from the TCR δ Repertoire in the Peripheral Blood
Open accessAbstract
The skin and the intestinal mucosa form surfaces to external environments and share similarities in anatomic structure and immunologic defense. In healthy humans, intestinal gamma/delta T cells express a highly restricted gamma/delta T cell receptor repertoire whereas gamma/delta T cells of the skin were thought to express a polyclonal repertoire. Herein we report, using complementarity-determining region 3 size spectratyping and nucleotide sequencing of T cell receptor DV1 and DV2 rearrangements, that the human skin is also composed of clonally expanded gamma/delta T cells that are widely distributed. Identical complementarity-determining region 3 profiles and T cell receptor delta rearrangements were found in two separate skin samples that were obtained as far as 2-10 cm apart. Furthermore, analysis of peripheral blood mononuclear cells of these subjects clearly demonstrated that the skin harbors a unique population of gamma/delta T cells that is distinct from that in the peripheral blood. In addition comparable data were obtained irrespective of whether DNA or RNA was analyzed, indicating that the observed oligoclonality is not secondary to the expression of large amounts of mRNA from a few activated cells. Thus, gamma/delta T cells of the skin and the intestine both express an oligoclonal repertoire that enables them to respond to a variety of deleterious antigens without the need for diverse T cell receptors, possibly by recognition of stress-induced self-antigens or of conserved foreign antigens.
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“IL-17 release by DETCs can promote DNA repair following exposure to UV radiation and protect the skin against potential opportunistic infections by releasing keratinocyte-derived antimicrobial peptides (37, 38).”
From Comparing Mouse and Human Tissue-Resident γδ T Cells (2022) · cites this paper as [37]
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Cites
Sequences of proteins of immunological interest
Kabat, B. E. A. (1984) · Analytical Biochemistry · doi:10.1016/0003-2697(84)90805-4 · Cited by 3,363
Simplified mammalian DNA isolation procedure
Laird, P. W., Zijderveld, A., Linders, K., Rudnicki, M. A., Jaenisch, R., & Berns, A. J. M. (1991) · Nucleic Acids Research · doi:10.1093/nar/19.15.4293 · Cited by 1,497
Recognition of Stress-Induced MHC Molecules by Intestinal Epithelial γδ T Cells
Groh, V., Steinle, A., Bauer, S., & Spies, T. A. (1998) · Science · doi:10.1126/science.279.5357.1737 · Cited by 1,142
γδ Cells: A Right Time and a Right Place for a Conserved Third Way of Protection
Hayday, A. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.975 · Cited by 1,134
Broad tumor-associated expression and recognition by tumor-derived γδ T cells of MICA and MICB
Groh, V., Rhinehart, R. L., Secrist, H., Bauer, S., Grabstein, K. H., & Spies, T. A. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.12.6879 · Cited by 1,026
Modlin, R. L., Pirmez, C., Hofman, F. M., Torigian, V. K., Uyemura, K., Rea, T. H., Bloom, B. R., & Brenner, M. B. (1989) · Nature · doi:10.1038/339544a0 · Cited by 573
Limited diversity of γδ antigen receptor genes of thy-1+ dendritic epidermal cells
Asarnow, D. M., Kuziel, W. A., Bonyhad, M., Tigelaar, R. E., Tucker, P. W., & Allison, J. P. (1988) · Cell · doi:10.1016/0092-8674(88)90139-0 · Cited by 517
CDR3 length in antigen-specific immune receptors.
Rock, E. P., Sibbald, P. R., Davis, M. M., & Chien, Y. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.179.1.323 · Cited by 515
The anatomical basis of intestinal immunity
Mowat, A. M., & Viney, J. L. (1997) · Immunological Reviews · doi:10.1111/j.1600-065x.1997.tb00966.x · Cited by 493
Inflammatory Skin Diseases, T Cells, and Immune Surveillance
Robert, C., & Kupper, T. S. (1999) · New England Journal of Medicine · doi:10.1056/nejm199912093412407 · Cited by 474
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Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice Is Mediated via the IL-23/IL-17 Axis
van der Fits, L., Mourits, S., Voerman, J. S. A., Kant, M., Boon, L., Laman, J. D., Cornelissen, F., Mus, A.-M. C., Florencia, E. F., Prens, E. P., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0802999 · Cited by 2,259
Regulation of Cutaneous Malignancy by γδ T Cells
Girardi, M., Oppenheim, D. E., Steele, C. R., Lewis, J. M., Glusac, E. J., Filler, R. B., Hobby, P., Sutton, B. J., Tigelaar, R. E., & Hayday, A. (2001) · Science · doi:10.1126/science.1063916 · Cited by 1,068
Does the Immune System See Tumors as Foreign or Self?
Pardoll, D. M. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141135 · Cited by 770
Intraepithelial lymphocytes: exploring the Third Way in immunology
Hayday, A., Theodoridis, E., Ramsburg, E., & Shires, J. (2001) · Nature Immunology · doi:10.1038/ni1101-997 · Cited by 491
γδ T cells in homeostasis and host defence of epithelial barrier tissues
Nielsen, M. M., Witherden, D. A., & Havran, W. L. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.101 · Cited by 479
Metadata
- Authors
- Holtmeier, W., Pfänder, M., Hennemann, A., Caspary, W. F., Zollner, T. M., & Kaufmann, R.
- Affiliations
- Goethe University Frankfurt (DE)
- Corresponding author
- Holtmeier, Wolfgang
- ORCID
- Zollner, Thomas M.
- Venue
- Journal of Investigative Dermatology
- Publisher
- Elsevier BV
- Published
- 2001-02
- Volume
- 116
- Issue
- 2
- Pages
- 275-280
- ISSN
- 0022-202X (ISSN-L)
- OpenAlex
- W2045500037
- Cited by
- 101
- References
- 44
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 6 · 2023: 7 · 2022: 3 · 2021: 3 · 2020: 8 · 2019: 1 · 2018: 8 · 2017: 3 · 2016: 2 · 2015: 3 · 2014: 7 · 2013: 5 · 2012: 2
- FWCI
- 1.41
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Investigative Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Keywords
- γδ T cells, T cell receptor delta chain, skin, peripheral blood, clonal expansion, T-cell receptor gene rearrangement, skin immune system, intestinal mucosa
- MeSH terms
- Clone Cells, Humans, Skin, Receptors, Antigen, T-Cell, gamma-delta, Gene Expression Profiling, Complementarity Determining Regions
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