Keratinocyte Survival, Differentiation, and Death: Many Roads Lead to Mitogen-Activated Protein Kinase
Open accessAbstract
The epidermis is a dynamic and continually renewing surface that provides and maintains a life-sustaining interface with the environment. The epidermal keratinocyte, the major cell type of the epidermis, undergoes a complex and carefully choreographed program of differentiation. This process requires a balance between keratinocyte proliferation, differentiation, and apoptosis. This overview will concentrate on cascades that regulate the balance between keratinocyte cell proliferation and survival, and apoptosis and cell differentiation, with a particular emphasis on the role of the mitogen-activated protein kinase cascades. A summary of the literature suggests that extracellular regulated kinases function to promote keratinocyte proliferation and survival, whereas p38 mitogen-activated protein kinase functions to promote differentiation and apoptosis.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Cited by
Sorted by citations
Lai, Y., Li, D., Li, C., Muehleisen, B., Radek, K. A., Park, H. J., Jiang, Z., Li, Z., Lei, H., Quan, Y., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.04.010 · Cited by 261 · see citing works
Mailleux, A. A., Overholtzer, M., Schmelzle, T., Bouillet, P., Strasser, A., & Brugge, J. S. (2007) · Developmental Cell · doi:10.1016/j.devcel.2006.12.003 · Cited by 255 · see citing works
Epidermal terminal differentiation depends on B lymphocyte-induced maturation protein-1
Magnúsdóttir, E., Kalachikov, S., Mizukoshi, K., Savitsky, D., Ishida-Yamamoto, A., Panteleyev, A. A., & Calame, K. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707323104 · Cited by 152 · see citing works
Zhao, G., Lyu, J., Veniaminova, N. A., Zarnowski, R., Mattos, E., Johnson, C. J., Quintanilla, D., Hautau, H., Hold, L. A., Xu, B., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-60876-1 · Cited by 32 · see citing works
- Authors
- Eckert, R. L., Efimova, T., Dashti, S. R., Balasubramanian, S., Deucher, A., Crish, J. F., Sturniolo, M., & Bone, F.
- Affiliations
- Case Western Reserve University (US)
- Corresponding author
- Eckert, Richard L.
- Venue
- Journal of Investigative Dermatology Symposium Proceedings
- Publisher
- Elsevier BV
- Published
- 2002-12
- Volume
- 7
- Issue
- 1
- Pages
- 36-40
- ISSN
- 1087-0024 (ISSN-L)
- OpenAlex
- W2069889664
- Cited by
- 125
- References
- 0
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 1 · 2023: 3 · 2022: 7 · 2021: 5 · 2020: 6 · 2019: 3 · 2018: 10 · 2017: 5 · 2016: 7 · 2015: 6 · 2014: 5 · 2013: 2 · 2012: 2
- FWCI
- 65.71
- Type
- conference paper
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Investigative Dermatology Symposium Proceedings (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (P30CA134274)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR 39750, P30AR039750)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Melanoma and MAPK Pathways
- Keywords
- keratinocytes, epidermis, keratinocyte differentiation, apoptosis, cell proliferation, cell survival, mitogen-activated protein kinase, extracellular signal-regulated kinase, p38 MAPK, epidermal regeneration
- MeSH terms
- Animals, Cell Differentiation, Cell Survival, Humans, Keratinocytes, Cell Death, Mitogen-Activated Protein Kinases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
