Cited by 598Wound Healing and TreatmentsProtease and Inhibitor MechanismsLiver physiology and pathology

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Interactions of cytokines, growth factors, and proteases in acute and chronic wounds

Mast, Bruce A., Schultz, Gregory S.·1996·Wound Repair and Regeneration

DOI 10.1046/j.1524-475x.1996.40404.x

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Abstract

A healing wound represents a complex series of interactions between cells, soluble mediators, and extracellular matrix. Within this multifaceted environment, there are multiple regulatory points which control the ordered series of events that lead to normal tissue repair. An alteration in this physiologic network can lead to the development of a chronic wound. This article presents an update on the numerous mediators that exist within the wound environment in both acute normal healing and chronic nonhealing wounds. We also present a hypothesis which may provide a conceptual pathophysiologic mechanism with which to understand all chronic wounds.

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Authors: Mast, B. A., & Schultz, G. S.
Affiliations: University of Florida Health (US)
University of Florida (US)
Corresponding author: Mast, Bruce A.
Venue: Wound Repair and Regeneration
Publisher: Wiley
Published: 1996-10
Volume: 4
Issue: 4
Pages: 411-420
ISSN: 1067-1927 (ISSN-L)
1524-475X
DOI: 10.1046/j.1524-475x.1996.40404.x
OpenAlex: W1970955409
Cited by: 598
References: 0
Citations by year: 2026: 14 · 2025: 25 · 2024: 26 · 2023: 23 · 2022: 23 · 2021: 37 · 2020: 32 · 2019: 31 · 2018: 39 · 2017: 24 · 2016: 25 · 2015: 24 · 2014: 24 · 2013: 33 · 2012: 30
FWCI: 4.15
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 2128 d)
Locations: Wound Repair and Regeneration (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Surgery › Wound Healing and Treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Keywords: chronic wounds, acute wound healing, cytokines, growth factors, proteolytic enzymes, extracellular matrix, tissue repair

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Interactions of cytokines, growth factors, and proteases in acute and chronic wounds

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