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Cited by 46Developmental Biology and Gene RegulationDNA Repair MechanismsEvolution and Genetic Dynamics

Protection of DNA during early development: adaptations and evolutionary consequences

Epel, David·2003·Evolution & Development
DOI 10.1046/j.1525-142x.2003.03013.x
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Abstract

The rapidly dividing cleavage stages of embryos do not have the typical responses to cell damage, such as induction of the heat shock response, use of mitotic checkpoints, or use of apoptosis to eliminate severely damaged cells. This could create problems with integrity of DNA, but the solution in these embryos appears to be a "be prepared" approach, in which specific adaptations are used to minimize DNA damage during cleavage and the use of apoptosis at the mid-blastula transition to remove any cells that were nevertheless damaged. It has been assumed that this approach has evolved because of the advantage of rapid production of a motile larvae. Alternatively, this particular approach may have the selective advantage of increasing mutation rate when there are greater environmental stresses. This could provide more variants on which selective pressures could act and thus accelerate evolution during environmentally stressful periods.

Integrity signals

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  • Some defense gene products may be packaged into eggs during oogenesis to provide adequate defense during early cleavage stages.

    “Some defense gene products may be packaged into eggs during oogenesis to provide adequate defense during early cleavage stages when divisions are rapid and nucleus:cytoplasm ratios are low (Epel, 2003;Giudice et al., 1999;Hamdoun et al., 2004), a period in which gene expression is unlikely to result in efficient upregulation of protein concentration.”

    From The chemical defensome: Environmental sensing and response genes in the Strongylocentrotus purpuratus genome (2006) · cites this paper as Epel, 2003

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Authors
Epel, D.
Affiliations
Hopkins Marine Station (US)
Corresponding author
Epel, David
Venue
Evolution & Development
Publisher
Wiley
Published
2002-12-19
Volume
5
Issue
1
Pages
83-88
ISSN
  • 1520-541X (ISSN-L)
  • 1525-142X
DOI
10.1046/j.1525-142x.2003.03013.x
OpenAlex
W2092962351
Cited by
46
References
34
Citations by year
2026: 2 · 2025: 1 · 2024: 2 · 2022: 1 · 2021: 1 · 2017: 1 · 2014: 1 · 2013: 3 · 2012: 5
FWCI
0.17
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Evolution & Development (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
Keywords
DNA damage, early embryonic development, cleavage, midblastula transition, apoptosis, heat shock response, spindle assembly checkpoint, mutation rate, adaptive evolution, environmental stress, larval development
MeSH terms
Adaptation, Biological, Animals, Antineoplastic Agents, Phytogenic, Calcium Channel Blockers, DNA, DNA Damage, Mitosis, Mollusca, Mutation, Oocytes, Sea Urchins, Time Factors, Ultraviolet Rays, Urochordata, Verapamil, Vinblastine, Apoptosis, Gene Expression Regulation, Developmental, Evolution, Molecular, ATP Binding Cassette Transporter, Subfamily B, Member 1

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