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Cited by 176Asthma and respiratory diseasesHealth Systems, Economic Evaluations, Quality of LifeChronic Obstructive Pulmonary Disease (COPD) Research

The DOI matches its Crossref record; 68 of the 69 references it cites were found in a registry or an index.

Effects of depressive symptoms on health-related quality of life in asthma patients

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Mancuso, Carol A., Peterson, Margaret G. E., Charlson, Mary E.·2000·Journal of General Internal Medicine
DOI 10.1046/j.1525-1497.2000.07006.xPMC PMC1495457
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Abstract

Objective To assess the effects of depressive symptoms on asthma patients' reports of functional status and health-related quality of life.Design Cross-sectional study.Setting Primary care internal medicine practice at a tertiary care center in New York City.Patients We studied 230 outpatients between the ages of 18 and 62 years with moderate asthma.Measurements and main results Patients were interviewed in person in English or Spanish with two health-related quality-of-life measures, the disease-specific Asthma Quality of Life Questionnaire (AQLQ) (possible score range, 1 to 7; higher scores reflect better function) and the generic Medical Outcomes Study SF-36 (general population mean is 50 for both the Physical Component Summary [PCS] score and Mental Component Summary [MCS] score). Patients also completed a screen for depressive symptoms, the Geriatric Depression Scale (GDS), and a global question regarding current disease activity. Stepwise multivariate analyses were conducted with the AQLQ and SF-36 scores as the dependent variables and depressive symptoms, comorbidity, asthma, and demographic characteristics as independent variables. The mean age of patients was 41 +/- SD 11 years and 83% were women. The mean GDS score was 11 +/- SD 8 (possible range, 0 to 30; higher scores reflect more depressive symptoms), and a large percentage of patients, 45%, scored above the threshold considered positive for depression screening. Compared with patients with a negative screen for depressive symptoms, patients with a positive screen had worse composite AQLQ scores (3.9 +/- SD 1.3 vs 2.8 +/- SD 0.8, P <.0001) and worse PCS scores (40 +/- SD 11 vs 34 +/- SD 8, P <.0001) and worse MCS scores (48 +/- SD 11 vs 32 +/- SD 10, P <.0001) scores. In stepwise analyses, current asthma activity and GDS scores had the greatest effects on patient-reported health-related quality of life, accounting for 36% and 11% of the variance, respectively, for the composite AQLQ, and 11% and 38% of the variance, respectively, for the MCS in multivariate analyses.Conclusions Nearly half of asthma patients in this study had a positive screen for depressive symptoms. Asthma patients with more depressive symptoms reported worse health-related quality of life than asthma patients with similar disease activity but fewer depressive symptoms. Given the new emphasis on functional status and health-related quality of life measured by disease-specific and general health scales, we conclude that psychological status indicators should also be considered when patient-derived measures are used to assess outcomes in asthma.

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Metadata

Authors
Mancuso, C. A., Peterson, M. G. E., & Charlson, M. E.
Affiliations
  • Hospital for Special Surgery (US)
  • NewYork–Presbyterian Hospital (US)
Corresponding author
Mancuso, Carol A.
ORCID
Venue
Journal of General Internal Medicine
Publisher
Springer Science and Business Media LLC
Published
2000-05
Volume
15
Issue
5
Pages
301-310
ISSN
  • 0884-8734 (ISSN-L)
  • 1525-1497
DOI
10.1046/j.1525-1497.2000.07006.x
PMC
PMC1495457
OpenAlex
W2008421651
Cited by
176
References
69
Citations by year
2025: 1 · 2024: 4 · 2023: 3 · 2022: 6 · 2021: 1 · 2020: 3 · 2019: 3 · 2018: 4 · 2017: 5 · 2016: 9 · 2015: 4 · 2014: 9 · 2013: 9 · 2012: 11
FWCI
5.73
Type
journal article
Language
en
Open access
Locations
  • Journal of General Internal Medicine (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
  • Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
Keywords
depressive symptoms, depression, asthma, health-related quality of life, Asthma Quality of Life Questionnaire, SF-36, Geriatric Depression Scale, comorbidities, functional status, primary care outpatients, depression screening, Spanish-speaking patients, New York City residents, racial and ethnic minorities, socioeconomic status, urban health disparities
MeSH terms
Adult, Asthma, Cross-Sectional Studies, Depression, Female, Humans, Male, Middle Aged, Quality of Life, Surveys and Questionnaires, Socioeconomic Factors, Chi-Square Distribution, Linear Models

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