The DOI matches its Crossref record.
Apoptosis and Suppression of Tumor Growth by Artepillin C Extracted from Brazilian Propolis
Abstract
Artepillin C was extracted from Brazilian propolis. Artepillin C (3,5-diprenyl-4-hydroxycinnamic acid) has a molecular weight of 300.40 and possesses antibacterial activity. When artepillin C was applied to human and murine malignant tumor cells in vitro and in vivo, artepillin C exhibited a cytotoxic effect and the growth of tumor cells was clearly inhibited. The artepillin C was found to cause significant damage to solid tumor and leukemic cells by the MTT assay, DNA synthesis assay, and morphological observation in vitro. When xenografts of human tumor cells were transplanted into nude mice, the cytotoxic effects of artepillin C were most noticeable in carcinoma and malignant melanoma. Apoptosis, abortive mitosis, and massive necrosis combined were identified by histological observation after intratumor injection of 500 microg of artepillin C three times a week. In addition to suppression of tumor growth, there was an increase in the ratio of CD4/CD8 T cells, and in the total number of helper T cells. These findings indicate that artepillin C activates the immune system, and possesses direct antitumor activity.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Propolis, an old remedy used in modern medicine
Castaldo, S., & Capasso, F. (2002) · Fitoterapia · doi:10.1016/s0367-326x(02)00185-5 · Cited by 744
Composition and functional properties of propolis (bee glue): A review
Anjum, S. I., Ullah, A., Khan, K. A., Attaullah, M., Khan, H., Ali, H., Bashir, M. A., Tahir, M., Ansari, M. J., Ghramh, H. A., et al. (2019) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2018.08.013 · Cited by 648
Recent Progress of Propolis for Its Biological and Chemical Compositions and Its Botanical Origin
Toreti, V. C., Sato, H. H., Pastore, G. M., & Park, Y. K. (2013) · Evidence-Based Complementary and Alternative Medicine · doi:10.1155/2013/697390 · Cited by 481
Brazilian Red Propolis—Chemical Composition and Botanical Origin
Daugsch, A., Moraes, C. S., Fort, P., & Park, Y. K. (2008) · Evidence-Based Complementary and Alternative Medicine · doi:10.1093/ecam/nem057 · Cited by 331
Comparison of the Biological Potential and Chemical Composition of Brazilian and Mexican Propolis
Silva-Beltrán, N. P., Umsza-Guez, M. A., Ramos Rodrigues, D. M., Gálvez-Ruiz, J. C., de Paula Castro, T. L., & Balderrama-Carmona, A. P. (2021) · Applied Sciences · doi:10.3390/app112311417 · Cited by 30
Metadata
- Authors
- Kimoto, T., Arai, S., Kohguchi, M., Aga, M., Nomura, Y., Micallef, M. J., Kurimoto, M., & Mito, K.
- Venue
- Cancer Detection <html_ent glyph="@amp;" ascii="&"/> Prevention
- Publisher
- Wiley
- Published
- 1998-11
- Volume
- 22
- Issue
- 6
- Pages
- 506-515
- ISSN
- 0361-090X (ISSN-L)
- 1525-1500
- OpenAlex
- W2037279263
- Cited by
- 206
- References
- 0
- FWCI
- 4.25
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Apoptosis and Suppression of Tumor Growth by Artepillin C Extracted from Brazilian Propolis. https://app.cochat.ai/papers/10.1046/j.1525-1500.1998.00020.x
- The paper
- Kimoto, T., Arai, S., Kohguchi, M., Aga, M., Nomura, Y., Micallef, M. J., Kurimoto, M., & Mito, K. (1998). Apoptosis and Suppression of Tumor Growth by Artepillin C Extracted from Brazilian Propolis. Cancer Detection <html_ent glyph="@amp;" ascii="&"/> Prevention. https://doi.org/10.1046/j.1525-1500.1998.00020.x
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
