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Chronic Anterior Thalamus Stimulation for Intractable Epilepsy
Abstract
Summary: Purpose: A significant number of patients with epilepsy remain poorly controlled despite antiepileptic medication (AED) treatment and are not eligible for resective surgery. Novel therapeutic methods are required to decrease seizure burden in this population. Several observations have indicated that the anterior thalamic region plays an important role in the maintenance and propagation of seizures. We investigated neuromodulation of the anterior thalamus by using deep‐brain stimulation (DBS) in patients with intractable seizures. Methods: Five patients with medically refractory epilepsy underwent stereotactic placement of and received stimulation through bilateral DBS electrodes in the anterior thalamus. Results: Treatment showed a statistically significant decrease in seizure frequency, with a mean reduction of 54% (mean follow‐up, 15 months). Two of the patients had a seizure reduction of ≥75%. No adverse effects were observed after DBS electrode insertion or stimulation. Unexpectedly, the observed benefits did not differ between stimulation‐on and stimulation‐off periods. Conclusions: DBS of the anterior thalamus is a safe procedure and possibly effective in patients with medically resistant seizures.
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Cited by
Deep Brain Stimulation for Treatment-Resistant Depression
Mayberg, H. S., Lozano, A. M., Voon, V., McNeely, H. E., Seminowicz, D., Hamani, C., Schwalb, J. M., & Kennedy, S. H. (2005) · Neuron · doi:10.1016/j.neuron.2005.02.014 · Cited by 4,059
Self-citationElectrical stimulation of the anterior nucleus of thalamus for treatment of refractory epilepsy
Fisher, R., Salanova, V., Witt, T., Worth, R., Henry, T., Gross, R., Oommen, K., Osorio, I., Nazzaro, J., Labar, D., et al. (2010) · Epilepsia · doi:10.1111/j.1528-1167.2010.02536.x · Cited by 1,918
Responsive cortical stimulation for the treatment of medically intractable partial epilepsy
Morrell, M. J. (2011) · Neurology · doi:10.1212/wnl.0b013e3182302056 · Cited by 1,282
Implanted Neural Interfaces: Biochallenges and Engineered Solutions
Grill, W. M., Norman, S. E., & Bellamkonda, R. V. (2009) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-061008-124927 · Cited by 488
Electrical brain stimulation for epilepsy
Fisher, R. S., & Velasco, A. L. (2014) · Nature Reviews Neurology · doi:10.1038/nrneurol.2014.59 · Cited by 402
Metadata
- Authors
- Hodaie, M., Wennberg, R. A., Dostrovsky, J. O., & Lozano, A. M.
- Venue
- Epilepsia
- Publisher
- Wiley
- Published
- 2002-06
- Volume
- 43
- Issue
- 6
- Pages
- 603-608
- ISSN
- 0013-9580 (ISSN-L)
- 1528-1167
- OpenAlex
- W1989017031
- Cited by
- 605
- References
- 0
- FWCI
- 14.44
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hodaie, M., Wennberg, R. A., Dostrovsky, J. O., & Lozano, A. M. (2002). Chronic Anterior Thalamus Stimulation for Intractable Epilepsy. Epilepsia. https://doi.org/10.1046/j.1528-1157.2002.26001.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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