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Cited by 49Atrial Fibrillation Management and OutcomesCardiac Arrhythmias and TreatmentsCardiac pacing and defibrillation studies

Pulmonary vein isolation for atrial fibrillation in patients with symptomatic sinus bradycardia or pauses

KHAYKIN, YAARIV, MARROUCHE, NASSIR F., MARTIN, DAVID O., SALIBA, WALID, SCHWEIKERT, ROBERT, WEXMAN, MARK, STRUNK, BRIAN, BEHEIRY, SALWA +6 more·2004·Journal of Cardiovascular Electrophysiology
DOI 10.1046/j.1540-8167.2004.03279.x
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Abstract

INTRODUCTION: Sick sinus syndrome is commonly associated with tachyarrhythmias and bradyarrhythmias that often are symptomatic. The aim of this study was to assess the effect of pulmonary vein isolation in patients with sick sinus syndrome and atrial fibrillation (AF). METHODS AND RESULTS: Three hundred fourteen consecutive patients who underwent pulmonary vein isolation between December 2000 and January 2002 were included in the study. Thirty-one patients had sick sinus syndrome, which was defined as a preprocedural history of symptomatic sinus bradycardia or pauses. Endpoints included AF recurrence, change in the frequency of sinus pauses, and symptoms of presyncope or syncope, as well as mean heart rate and percentage of atrial pacing in patients with pacemakers implanted prior to the pulmonary vein isolation. Patients had AF for an average of 6 +/- 3 years. Patients were 58 +/-8 years old and had ejection fractions of 55 +/- 4%. Sixty-one percent had implanted pacemakers. AF recurred within 6 months in 4 patients. Two had a successful second pulmonary vein isolation procedure. There were no recurrences of presyncopal events (P < 0.05) or documented sinus pauses (P < 0.05) after successful pulmonary vein isolation in the patients without permanent pacemakers. Patients with pacemakers had a 13-fold reduction in the percentage of atrial pacing (P < 0.05). Both groups showed a significant increase in average heart rates at 6-month follow-up. CONCLUSION: Cure of AF by pulmonary vein isolation helped resolve the clinical manifestations of sick sinus syndrome, suggesting that the occurrence of AF and/or the associated treatment could be partially responsible for sick sinus syndrome.

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Authors
KHAYKIN, Y., MARROUCHE, N. F., MARTIN, D. O., SALIBA, W., SCHWEIKERT, R., WEXMAN, M., STRUNK, B., BEHEIRY, S., SAAD, E., BHARGAVA, M., BURKHARDT, J. D., JOSEPH, G., TCHOU, P., & NATALE, A.
Affiliations
Cleveland Clinic (US)
Corresponding author
NATALE, ANDREA
ORCID
Venue
Journal of Cardiovascular Electrophysiology
Publisher
Wiley
Published
2004-07
Volume
15
Issue
7
Pages
784-789
ISSN
  • 1045-3873 (ISSN-L)
  • 1540-8167
DOI
10.1046/j.1540-8167.2004.03279.x
OpenAlex
W2088521949
Cited by
49
References
55
Citations by year
2026: 1 · 2025: 1 · 2024: 3 · 2023: 3 · 2022: 3 · 2021: 3 · 2020: 4 · 2019: 1 · 2018: 3 · 2017: 3 · 2016: 5 · 2015: 1 · 2014: 1 · 2013: 2 · 2012: 1
FWCI
1.54
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 11 d)
Locations
  • Journal of Cardiovascular Electrophysiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
Keywords
pulmonary vein isolation, atrial fibrillation, sick sinus syndrome, sinus bradycardia, sinus pause, implantable pacemaker, atrial pacing, presyncope, syncope, heart rate, catheter ablation
MeSH terms
Analysis of Variance, Atrial Fibrillation, Electrocardiography, Female, Humans, Male, Middle Aged, Pacemaker, Artificial, Pulmonary Veins, Recurrence, Sick Sinus Syndrome, Chi-Square Distribution, Treatment Outcome, Catheter Ablation

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