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Diabetes-Haufigkeit bei Akromegalie und Cushing-Syndrom
Abstract
In a retrospective study glucose metabolism was investigated in 206 patients with acromegaly and 131 patients with Cushing's disease. 40.5% of the patients with hypersomatotropism and 32.0% of the patients with hypercortisolism suffered from overt diabetes mellitus. Impaired glucose tolerance was present prior to therapy in 28.2% and 30.6% of the patients, respectively. In acromegaly the incidence of overt diabetes mellitus was higher in women than in men, but no difference existed in the distribution of impaired glucose tolerance between both sexes. No correlation was found between growth hormone levels and occurrence of diabetes. In acromegaly and Cushing's disease overt diabetes increased with advanced age. Diabetes mellitus occurred independently from the etiology of hypercortisolism.
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“From % to % of patients with endogenous CS have DM, and % to % have defective glucose tolerance, so the overall prevalence of glucose metabolism impairments can come close to %, as shown in Table (, , -).”
From Glucose Metabolism Abnormalities in Cushing Syndrome: From Molecular Basis to Clinical Management (2017) · cites this paper as [182]
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Arnaldi, G., Angeli, A., Atkinson, A. B., Bertagna, X., Cavagnini, F., Chrousos, G. P., Fava, G. A., Findling, J. W., Gaillard, R. C., Grossman, A. B., et al. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030871 · Cited by 1,362
Systemic Complications of Acromegaly: Epidemiology, Pathogenesis, and Management
Colao, A. A. L., Ferone, D., Marzullo, P., & Lombardi, G. (2004) · Endocrine Reviews · doi:10.1210/er.2002-0022 · Cited by 1,313
Pathophysiology of diabetes: An overview
Aga, S. S., Banday, M. Z., & Nissar, S. (2020) · Avicenna Journal of Medicine · doi:10.4103/ajm.ajm_53_20 · Cited by 949
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Mancini, T., Kola, B., Mantero, F., Boscaro, M., & Arnaldi, G. (2004) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2004.02168.x · Cited by 278
Metadata
- Authors
- Biering, H., Knappe, G., Gerl, H., & Lochs, H.
- Affiliations
- Charité – Universitätsmedizin Berlin (DE)
- Venue
- Acta Medica Austriaca
- Publisher
- Wiley
- Published
- 2000-03
- Volume
- 27
- Issue
- 1
- Pages
- 27-31
- ISSN
- 0303-8173 (ISSN-L)
- 1563-2571
- OpenAlex
- W2102706056
- Cited by
- 113
- References
- 0
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 4 · 2022: 4 · 2021: 8 · 2020: 7 · 2019: 4 · 2018: 4 · 2017: 7 · 2016: 7 · 2015: 9 · 2014: 3 · 2013: 3 · 2012: 4
- FWCI
- 1.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Acta Medica Austriaca (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Keywords
- acromegaly, Cushing's disease, diabetes mellitus, impaired glucose tolerance, hypercortisolism, growth hormone excess, sex differences, age as risk factor, glucose metabolism
- MeSH terms
- Acromegaly, Adult, Age Factors, Aged, Cushing Syndrome, Diabetes Mellitus, Female, Humans, Male, Middle Aged, Retrospective Studies, Prevalence, Diabetes Complications
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- CoChat. (2026). Citation check: Diabetes-Haufigkeit bei Akromegalie und Cushing-Syndrom. https://app.cochat.ai/papers/10.1046/j.1563-2571.2000.00106.x
- The paper
- Biering, H., Knappe, G., Gerl, H., & Lochs, H. (2000). Diabetes-Haufigkeit bei Akromegalie und Cushing-Syndrom. Acta Medica Austriaca. https://doi.org/10.1046/j.1563-2571.2000.00106.x
