The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
The utility of the non‐human primate model for studying gene by environment interactions in behavioral research
Open accessAbstract
Variation in the serotonin transporter gene‐linked polymorphic region (5‐HTTLPR) has been associated with anxiety and harm avoidance and is weakly associated with a number of neuropsychiatric disorders, including Type II alcoholism, which has a high rate of comorbidity with antisocial personality disorder. Studies have also demonstrated interactions between 5‐HTTLPR variation and environmental stress on the incidence of depression. As in humans, there is a serotonin transporter gene promoter length polymorphism in rhesus macaques that produces similar decreases in transcriptional efficiency. Macaques with histories of early‐life stress have been shown to exhibit impulsive aggression, incompetent social behavior and increased behavioral and endocrine responsivity to stress. In this paper, we review studies performed previously in our lab and present preliminary data examininng interactions between early rearing and serotonin transporter gene promoter variation on the incidences of play behavior and aggression in infant rhesus macaques. The data presented here highlight the importance of considering gene‐environment interactions when studying childhood risk factors for aggression, anxiety and related neuropsychiatric disorders and support the use of the nonhuman primate for studing gene by environment interactions in behavioral research.
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Citations
Cites
Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene
Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., McClay, J., Mill, J., Martin, J., Braithwaite, A., et al. (2003) · Science · doi:10.1126/science.1083968 · Cited by 8,120
Serotonin transporter genetic variation and the response of the human amygdala.
Hariri, A. R., Mattay, V. S., Tessitore, A., Kolachana, B., Fera, F., Goldman, D., Egan, M. F., & Weinberger, D. R. (2002) · Science · doi:10.1126/science.1071829 · Cited by 2,340
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Cited by
Differential susceptibility to the environment: an evolutionary--neurodevelopmental theory
Ellis, B. J., Boyce, W. T., Belsky, J., Bakermans-Kranenburg, M. J., & van Ijzendoorn, M. H. (2011) · Development and Psychopathology · doi:10.1017/s0954579410000611 · Cited by 1,564
Caspi, A., Hariri, A. R., Holmes, A., Uher, R., & Moffitt, T. E. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.09101452 · Cited by 1,346
Coping styles and behavioural flexibility: towards underlying mechanisms
Coppens, C. M., de Boer, S. F., & Koolhaas, J. M. (2010) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2010.0217 · Cited by 646
Targeting the murine serotonin transporter: insights into human neurobiology
Murphy, D. L., & Lesch, K.-P. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2284 · Cited by 478
Self-citationBarr, C. S., Newman, T. K., Shannon, C., Parker, C., Dvoskin, R. L., Becker, M. L., Schwandt, M., Champoux, M., Lesch, K. P., Goldman, D., et al. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.12.008 · Cited by 385
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Metadata
- Authors
- Barr, C. S., Newman, T. K., Becker, M. L., Parker, C. C., Champoux, M., Lesch, K. P., Goldman, D., Suomi, S. J., & Higley, J. D.
- Venue
- Genes, Brain and Behavior
- Publisher
- Wiley
- Published
- 2003-11-06
- Volume
- 2
- Issue
- 6
- Pages
- 336-340
- ISSN
- 1601-183X (ISSN-L)
- 1601-1848
- OpenAlex
- W2040973635
- Cited by
- 267
- References
- 2
- FWCI
- 4.66
- Type
- journal article
- Language
- en
- Open access
- bronze
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