Genetic Sensitivity to the Environment: The Case of the Serotonin Transporter Gene and Its Implications for Studying Complex Diseases and Traits

Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene

Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., McClay, J., Mill, J., Martin, J., Braithwaite, A., et al. (2003) · Science · doi:10.1126/science.1083968 · Cited by 8,120 · see citing works

Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region

Lesch, K.-P., Bengel, D., Heils, A., Sabol, S. Z., Greenberg, B. D., Petri, S., Benjamin, J., Müller, C. R., Hamer, D. H., & Murphy, D. L. (1996) · Science · doi:10.1126/science.274.5292.1527 · Cited by 5,162 · see citing works

Negative affectivity: the disposition to experience aversive emotional states

Watson, D., & Clark, L. A. (1984) · Psychological Bulletin · doi:10.1037/0033-2909.96.3.465 · Cited by 4,636 · see citing works

A Common Variant in the <i>FTO</i> Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity

Frayling, T. M., Timpson, N. J., Weedon, M. N., Zeggini, E., Freathy, R. M., Lindgren, C. M., Perry, J. R. B., Elliott, K. S., Lango, H., Rayner, N. W., et al. (2007) · Science · doi:10.1126/science.1141634 · Cited by 4,531 · see citing works

Statistical difficulties of detecting interactions and moderator effects.

McClelland, G. H., & Judd, C. M. (1993) · Psychological Bulletin · doi:10.1037/0033-2909.114.2.376 · Cited by 3,270 · see citing works

Serotonin transporter genetic variation and the response of the human amygdala.

Hariri, A. R., Mattay, V. S., Tessitore, A., Kolachana, B., Fera, F., Goldman, D., Egan, M. F., & Weinberger, D. R. (2002) · Science · doi:10.1126/science.1071829 · Cited by 2,340 · see citing works

Diathesis-stress theories in the context of life stress research: implications for the depressive disorders

Monroe, S. M., & Simons, A. D. (1991) · Psychological Bulletin · doi:10.1037/0033-2909.110.3.406 · Cited by 2,143 · see citing works

5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression

Pezawas, L., Meyer-Lindenberg, A., Drabant, E. M., Verchinski, B. A., Munoz, K. E., Kolachana, B. S., Egan, M. F., Mattay, V. S., Hariri, A. R., & Weinberger, D. R. (2005) · Nature Neuroscience · doi:10.1038/nn1463 · Cited by 1,980 · see citing works

A contrarian view of the five-factor approach to personality description.

Block, J. (1995) · Psychological Bulletin · doi:10.1037/0033-2909.117.2.187 · Cited by 1,682 · see citing works

Interaction Between the Serotonin Transporter Gene (5-HTTLPR), Stressful Life Events, and Risk of Depression: A Meta-analysis

Risch, N., Herrell, R., Lehner, T., Liang, K.-Y., Eaves, L., Hoh, J., Griem, A., Kovacs, M., Ott, J., & Merikangas, K. R. (2009) · JAMA · doi:10.1001/jama.2009.878 · Cited by 1,655 · see citing works

The Obesity-Associated FTO Gene Encodes a 2-Oxoglutarate-Dependent Nucleic Acid Demethylase

Gerken, T., Girard, C. A. J., Tung, Y. L., Webby, C. J., Saudek, V., Hewitson, K. S., Yeo, G. S. H., McDonough, M. A., Cunliffe, S. L., McNeill, L. A., et al. (2007) · Science · doi:10.1126/science.1151710 · Cited by 1,518 · see citing works

Replicating genotype–phenotype associations

NCI-NHGRI Working Group on Replication in Association Studies, Chanock, S. J., Manolio, T., Boehnke, M., Boerwinkle, E., Hunter, D. J., Thomas, G., Hirschhorn, J. N., Abecasis, G., Altshuler, D., et al. (2007) · Nature · doi:10.1038/447655a · Cited by 1,352 · see citing works

Gene–environment interactions in psychiatry: joining forces with neuroscience

Caspi, A., & Moffitt, T. E. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1925 · Cited by 1,300 · see citing works

The developmental role of serotonin: news from mouse molecular genetics

Gaspar, P., Cases, O., & Maroteaux, L. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1256 · Cited by 1,297 · see citing works

The ascent of mouse: advances in modelling human depression and anxiety

Cryan, J. F., & Holmes, A. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1825 · Cited by 1,198 · see citing works

Sturdy childhood predictors of adult antisocial behaviour: replications from longitudinal studies

Robins, L. N. (1978) · Psychological Medicine · doi:10.1017/s0033291700018821 · Cited by 994 · see citing works

Low early-life social class leaves a biological residue manifested by decreased glucocorticoid and increased proinflammatory signaling

Miller, G. E., Chen, E., Fok, A. K., Walker, H., Lim, A., Nicholls, E. F., Cole, S., & Kobor, M. S. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0902971106 · Cited by 822 · see citing works

Early-Life Blockade of the 5-HT Transporter Alters Emotional Behavior in Adult Mice

Ansorge, M. S., Zhou, M., Lira, A., Hen, R., & Gingrich, J. A. (2004) · Science · doi:10.1126/science.1101678 · Cited by 817 · see citing works

A Susceptibility Gene for Affective Disorders and the Response of the Human Amygdala

Hariri, A. R., Drabant, E. M., Munoz, K. E., Kolachana, B. S., Mattay, V. S., Egan, M. F., & Weinberger, D. R. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.2.146 · Cited by 815 · see citing works

Strategy for Investigating Interactions Between Measured Genes and Measured Environments

Moffitt, T. E., Caspi, A., & Rutter, M. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.5.473 · Cited by 784 · see citing works

Construct Validity: Advances in Theory and Methodology

Strauss, M., & Smith, G. T. (2009) · Annual Review of Clinical Psychology · doi:10.1146/annurev.clinpsy.032408.153639 · Cited by 768 · see citing works

Common Regulatory Variation Impacts Gene Expression in a Cell Type–Dependent Manner

Dimas, A. S., Deutsch, S., Stranger, B. E., Montgomery, S. B., Borel, C., Attar, H., Ingle, C., Beazley, C., Arcelus, M. G., Sekowska, M., et al. (2009) · Science · doi:10.1126/science.1174148 · Cited by 746 · see citing works

Meta‐analysis of the association between a serotonin transporter promoter polymorphism (5‐HTTLPR) and anxiety‐related personality traits

Sen, S., Burmeister, M., & Ghosh, D. (2004) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.20158 · Cited by 740 · see citing works

Amygdala-prefrontal coupling depends on a genetic variation of the serotonin transporter

Heinz, A., Braus, D. F., Smolka, M. N., Wrase, J., Puls, I., Hermann, D., Vollstädt‐Klein, S., Grüsser, S. M., Flor, H., Schumann, G., et al. (2004) · Nature Neuroscience · doi:10.1038/nn1366 · Cited by 700 · see citing works

An Obesity-AssociatedFTOGene Variant and Increased Energy Intake in Children

Cecil, J. E., Tavendale, R., Watt, P., Hetherington, M. M., & Palmer, C. N. A. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0803839 · Cited by 690 · see citing works

Genetics of emotional regulation: the role of the serotonin transporter in neural function

Hariri, A. R., & Holmes, A. (2006) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2006.02.011 · Cited by 666 · see citing works

Early experience and serotonin transporter gene variation interact to influence primate CNS function

Bennett, A. J., Lesch, K., Heils, A., Long, J. C., Lorenz, J. G., Shoaf, S. E., Champoux, M. C., Suomi, S. J., Linnoila, M., & Higley, J. D. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4000949 · Cited by 659 · see citing works

Inventorying stressful life events as risk factors for psychopathology: Toward resolution of the problem of intracategory variability.

Dohrenwend, B. P. (2006) · Psychological Bulletin · doi:10.1037/0033-2909.132.3.477 · Cited by 601 · see citing works

Gene×environment interactions at the serotonin transporter locus

Munafò, M. R., Durrant, C., Lewis, G., & Flint, J. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.06.009 · Cited by 576 · see citing works

Modern Approaches to Conceptualizing and Measuring Human Life Stress

Monroe, S. M. (2008) · Annual Review of Clinical Psychology · doi:10.1146/annurev.clinpsy.4.022007.141207 · Cited by 567 · see citing works

HPA Axis Reactivity: A Mechanism Underlying the Associations Among 5-HTTLPR, Stress, and Depression

Gotlib, I. H., Joormann, J., Minor, K. L., & Hallmayer, J. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.10.008 · Cited by 558 · see citing works

Obesity Associated Genetic Variation inFTOIs Associated with Diminished Satiety

Wardle, J., Carnell, S., Haworth, C. M. A., Farooqi, I. S., O’Rahilly, S., & Plomin, R. J. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-0472 · Cited by 526 · see citing works

The moderation by the serotonin transporter gene of environmental adversity in the aetiology of mental illness: review and methodological analysis

Uher, R., & McGuffin, P. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4002067 · Cited by 507 · see citing works

Targeting the murine serotonin transporter: insights into human neurobiology

Murphy, D. L., & Lesch, K.-P. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2284 · Cited by 478 · see citing works

Low Physical Activity Accentuates the Effect of the <i>FTO</i> rs9939609 Polymorphism on Body Fat Accumulation

Andreasen, C. H., Stender-Petersen, K. L., Mogensen, M. S., Torekov, S. S., Wegner, L., Andersen, G., Nielsen, A. L., Albrechtsen, A., Borch-Johnsen, K., Rasmussen, S. S., et al. (2008) · Diabetes · doi:10.2337/db07-0910 · Cited by 476 · see citing works

A relationship between serotonin transporter genotype and in vivo protein expression and alcohol neurotoxicity

Heinz, A., Jones, D. W., Mazzanti, C. M., Goldman, D. A., Ragan, P. W., Hommer, D. W., Linnoila, M., & Weinberger, D. R. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00171-7 · Cited by 462 · see citing works

The structural integrity of an amygdala-prefrontal pathway predicts trait anxiety

Kim, M. J., & Whalen, P. J. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.2335-09.2009 · Cited by 433 · see citing works

The moderation by the serotonin transporter gene of environmental adversity in the etiology of depression: 2009 update

Uher, R., & McGuffin, P. (2010) · Molecular Psychiatry · doi:10.1038/mp.2009.123 · Cited by 424 · see citing works

Personality traits are differentially linked to mental disorders: A multitrait-multidiagnosis study of an adolescent birth cohort.

Krueger, R. F., Caspi, A., Moffitt, T. E., Silva, P. A., & McGee, R. (1996) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.105.3.299 · Cited by 423 · see citing works

Observational research, randomised trials, and two views of medical science

Vandenbroucke, J. P. (2008) · PLoS Medicine · doi:10.1371/journal.pmed.0050067 · Cited by 416 · see citing works

An immunogenetic and molecular basis for differences in outcomes of invasive group A streptococcal infections

Kotb, M., Norrby‐Teglund, A., McGeer, A., El-Sherbini, H., Dorak, M. T., Khurshid, A., Green, K., Peeples, J., Wade, J. A., Thomson, G. J., et al. (2002) · Nature Medicine · doi:10.1038/nm800 · Cited by 398 · see citing works

Measured Gene-Environment Interactions in Psychopathology: Concepts, Research Strategies, and Implications for Research, Intervention, and Public Understanding of Genetics

Moffitt, T. E., Caspi, A., & Rutter, M. (2006) · Perspectives on Psychological Science · doi:10.1111/j.1745-6916.2006.00002.x · Cited by 389 · see citing works

Rearing condition and rh5-HTTLPR interact to influence limbic-hypothalamic-pituitary-adrenal axis response to stress in infant macaques

Barr, C. S., Newman, T. K., Shannon, C., Parker, C., Dvoskin, R. L., Becker, M. L., Schwandt, M., Champoux, M., Lesch, K. P., Goldman, D., et al. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.12.008 · Cited by 385 · see citing works

Moderation of breastfeeding effects on the IQ by genetic variation in fatty acid metabolism

Caspi, A., Williams, B. S., Kim‐Cohen, J., Craig, I., Milne, B. J., Poulton, R., Schalkwyk, L. C., Taylor, A. W., Werts, H., & Moffitt, T. E. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704292104 · Cited by 385 · see citing works

The Obesity Gene, FTO, Is of Ancient Origin, Up-Regulated during Food Deprivation and Expressed in Neurons of Feeding-Related Nuclei of the Brain

Fredriksson, R., Hägglund, M., Olszewski, P. K., Stephansson, O., Jacobsson, J. A., Olszewska, A., Levine, A. S., Lindblom, J., & Schiöth, H. B. (2008) · Endocrinology · doi:10.1210/en.2007-1457 · Cited by 379 · see citing works

Beyond affect: A role for genetic variation of the serotonin transporter in neural activation during a cognitive attention task

Canli, T., Omura, K., Haas, B. W., Fallgatter, A. J., Constable, R. T., & Lesch, K. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503880102 · Cited by 353 · see citing works

Neural correlates of epigenesis

Canli, T., Qiu, M., Omura, K., Congdon, E., Haas, B. W., Amin, Z., Herrmann, M., Constable, R. T., & Lesch, K. (2006) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0601674103 · Cited by 338 · see citing works

Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy

Ross, C. J., Katzov-Eckert, H., Dubé, M., Brooks, B., Rassekh, S. R., Barhdadi, A., Zada, Y. F., Visscher, H., Brown, A. M. K., Rieder, M. J., et al. (2009) · Nature Genetics · doi:10.1038/ng.478 · Cited by 323 · see citing works

The Role of Orbitofrontal Cortex in Drug Addiction: A Review of Preclinical Studies

Schoenbaum, G. M., & Shaham, Y. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.06.003 · Cited by 314 · see citing works

Physical Activity and the Association of Common FTO Gene Variants With Body Mass Index and Obesity

Rampersaud, E., Mitchell, B. D., Pollin, T. I., Fu, M., Shen, H., O’Connell, J. R., Ducharme, J. L., Hines, S., Sack, P., Naglieri, R., et al. (2008) · Archives of Internal Medicine · doi:10.1001/archinte.168.16.1791 · Cited by 299 · see citing works

The relationship between stressful life events, the serotonin transporter (5-HTTLPR) genotype and major depression

Gillespie, N. A., Whitfield, J. B., WILLIAMS, B., Heath, A. C., & Martin, N. G. (2004) · Psychological Medicine · doi:10.1017/s0033291704002727 · Cited by 299 · see citing works

The neurobiology of individual differences in complex behavioral traits

Hariri, A. R. (2009) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.051508.135335 · Cited by 273 · see citing works

Interplay of genes and early mother–child relationship in the development of self‐regulation from toddler to preschool age

Kochanska, G., Philibert, R. A., & Barry, R. A. (2009) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2008.02050.x · Cited by 272 · see citing works

The utility of the non‐human primate model for studying gene by environment interactions in behavioral research

Barr, C. S., Newman, T. K., Becker, M. L., Parker, C. C., Champoux, M. C., Lesch, K., Goldman, D. A., Suomi, S. J., & Higley, J. D. (2003) · Genes Brain & Behavior · doi:10.1046/j.1601-1848.2003.00051.x · Cited by 267 · see citing works

Interactive Effect of Stressful Life Events and the Serotonin Transporter 5-HTTLPR Genotype on Posttraumatic Stress Disorder Diagnosis in 2 Independent Populations

Xie, P., Kranzler, H. R., Poling, J., Stein, M. B., Anton, R. F., Brady, K., Weiss, R. D., Farrer, L., & Gelernter, J. (2009) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.153 · Cited by 264 · see citing works

Effect of a Triallelic Functional Polymorphism of the Serotonin-Transporter-Linked Promoter Region on Expression of Serotonin Transporter in the Human Brain

Parsey, R. V., Hastings, R. S., Oquendo, M. A., Hu, X., Goldman, D., Huang, Y.-Y., Simpson, N., Arcement, J., Huang, Y., Ogden, R. T., et al. (2006) · American Journal of Psychiatry · doi:10.1176/appi.ajp.163.1.48 · Cited by 262 · see citing works

Evidence for a Gene-Environment Interaction in Predicting Behavioral Inhibition in Middle Childhood

Fox, N. A., Nichols, K. E., Henderson, H. A., Rubin, K. H., Schmidt, L. A., Hamer, D. H., Monique Ernst, D., & Pine, D. S. (2005) · Psychological Science · doi:10.1111/j.1467-9280.2005.01637.x · Cited by 262 · see citing works

Interaction Between Serotonin Transporter Gene Variation and RearingCondition in Alcohol Preference and Consumption in Female Primates

Barr, C. S., Newman, T. K., Lindell, S. G., Shannon, C., Champoux, M., Lesch, K., Suomi, S. J., Goldman, D. A., & Higley, J. D. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.11.1146 · Cited by 259 · see citing works

Size matters: just how big is BIG?: Quantifying realistic sample size requirements for human genome epidemiology

Burton, P. R., Hansell, A., Fortier, I., Manolio, T. A., Khoury, M. J., Little, J., & Elliott, P. (2008) · International Journal of Epidemiology · doi:10.1093/ije/dyn147 · Cited by 258 · see citing works

Characterization of the serotonin transporter knockout rat: A selective change in the functioning of the serotonergic system

Homberg, J. R., Olivier, J. D. A., Smits, B. M. G., Mul, J. D., Mudde, J., Verheul, M., Nieuwenhuizen, O. F. M., Cools, A. R., Ronken, E., Cremers, T. I. F. H., et al. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.03.030 · Cited by 258 · see citing works

A Functional Genetic Variation of the Serotonin (5-HT) Transporter Affects 5-HT1AReceptor Binding in Humans

David, S. P., Murthy, N. V., Rabiner, E. A., Munafo, M. R., Johnstone, E. C., Jacob, R., Walton, R. T., & Grasby, P. M. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3769-04.2005 · Cited by 257 · see citing works

Meta‐analysis of the association between two polymorphisms in the serotonin transporter gene and affective disorders

Lasky-Su, J. A., Faraone, S. V., Glatt, S. J., & Tsuang, M. T. (2004) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30104 · Cited by 256 · see citing works

Gene-by-environment (serotonin transporter and childhood maltreatment) interaction for anxiety sensitivity, an intermediate phenotype for anxiety disorders

Stein, M. B., Schork, N. J., & Gelernter, J. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301422 · Cited by 247 · see citing works

Serotonin transporter polymorphism related to amygdala excitability and symptom severity in patients with social phobia

Furmark, T., Tillfors, M., Garpenstrand, H., Marteinsdóttir, Í., Långström, B., Oreland, L., & Fredrikson, M. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.02.070 · Cited by 234 · see citing works

Genetics of human gene expression: mapping DNA variants that influence gene expression

Cheung, V. G., & Spielman, R. S. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2630 · Cited by 233 · see citing works

Variation of Human Amygdala Response During Threatening Stimuli as a Function of 5′HTTLPR Genotype and Personality Style

Bertolino, A., Arciero, G., Rubino, V., Latorre, V., Candia, M. D., Mazzola, V., Blasi, G., Caforio, G., Hariri, A. R., Kolachana, B. S., et al. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.02.031 · Cited by 223 · see citing works

Looking on the bright side: biased attention and the human serotonin transporter gene

Fox, E., Ridgewell, A., & Ashwin, C. (2009) · Proceedings of the Royal Society B: Biological Sciences · doi:10.1098/rspb.2008.1788 · Cited by 220 · see citing works

Genetic perspectives on the serotonin transporter

Murphy, D. L., Li, Q., Engel, S. R., Wichems, C. H., Andrews, A. M., Lesch, K., & Uhl, G. R. (2001) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00622-0 · Cited by 214 · see citing works

A framework for interpreting genome-wide association studies of psychiatric disorders

The Psychiatric GWAS Consortium Steering Committee (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.126 · Cited by 208 · see citing works

Sexual dichotomy of an interaction between early adversity and the serotonin transporter gene promoter variant in rhesus macaques

Barr, C. S., Newman, T. K., Schwandt, M. L., Shannon, C., Dvoskin, R. L., Lindell, S. G., Taubman, J., Thompson, B., Champoux, M., Lesch, K., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403763101 · Cited by 205 · see citing works

Physical activity attenuates the body mass index–increasing influence of genetic variation in the FTO gene

Vimaleswaran, K. S., Li, S., Zhao, J. H., Luan, J., Bingham, S. A., Khaw, K.-T., Ekelund, U., Wareham, N. J., & Loos, R. J. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.27652 · Cited by 202 · see citing works

Depression and the serotonin transporter 5-HTTLPR polymorphism: A review and a hypothesis concerning gene–environment interaction

Brown, G. W., & Harris, T. (2008) · Journal of Affective Disorders · doi:10.1016/j.jad.2008.04.009 · Cited by 199 · see citing works

A Genetically Mediated Bias in Decision Making Driven by Failure of Amygdala Control

Roiser, J. P., Martino, B. D., Tan, G. C.-Y., Kumaran, D., Seymour, B., Wood, N. W., & Dolan, R. J. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0407-09.2009 · Cited by 199 · see citing works

Serious obstetric complications interact with hypoxia-regulated/vascular-expression genes to influence schizophrenia risk

Nicodemus, K. K., Marenco, S., Batten, A. J., Vakkalanka, R., Egan, M. F., Straub, R. E., & Weinberger, D. R. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002153 · Cited by 192 · see citing works

Interaction between Childhood Trauma and Serotonin Transporter Gene Variation in Suicide

Roy, A., Hu, X., Janal, M. N., & Goldman, D. A. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301331 · Cited by 190 · see citing works

The Serotonin Transporter Promoter Polymorphism Is Associated with Cortisol Response to Psychosocial Stress

Way, B. M., & Taylor, S. E. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.10.021 · Cited by 188 · see citing works

Influence of the Serotonin Transporter Promoter Gene and Shyness on Children’s Cerebral Responses to Facial Expressions

Battaglia, M., Ogliari, A. L., Zanoni, A., Citterio, A., Pozzoli, U., Giorda, R., Maffei, C., & Marino, C. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.1.85 · Cited by 185 · see citing works

Pharmacological or genetic inactivation of the serotonin transporter improves reversal learning in mice

Brigman, J. L., Mathur, P., Harvey-White, J., Izquierdo, A., Saksida, L. M., Bussey, T. J., Fox, S., Deneris, E., Murphy, D. L., & Holmes, A. (2010) · Cerebral Cortex · doi:10.1093/cercor/bhp266 · Cited by 184 · see citing works

FTO Genotype Is Associated with Body Mass Index after the Age of Seven Years But Not with Energy Intake or Leisure-Time Physical Activity

Hakanen, M., Raitakari, O. T., Lehtimäki, T. J., Peltonen, N., Pahkala, K., Sillanmäki, L. H., Lagström, H., Viikari, J. S. A., Simell, O., & Rönnemaa, T. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1199 · Cited by 183 · see citing works

Prevention Effects Moderate the Association of 5-HTTLPR and Youth Risk Behavior Initiation: Gene × Environment Hypotheses Tested via a Randomized Prevention Design

Brody, G. H., Beach, S. R. H., Philibert, R. A., Chen, Y., & Murry, V. M. (2009) · Child Development · doi:10.1111/j.1467-8624.2009.01288.x · Cited by 181 · see citing works

Interactive Effects of the Serotonin Transporter 5-HTTLPR Polymorphism and Stressful Life Events on College Student Drinking and Drug Use

Covault, J., Tennen, H. A., Armeli, S., Conner, T. S., Herman, A. I., Cillessen, A. H. N., & Kranzler, H. R. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.05.018 · Cited by 179 · see citing works

Association of the serotonin transporter gene promoter region (5-HTTLPR) polymorphism with biased attention for emotional stimuli.

Beevers, C. G., Wells, T. T., Ellis, A. J., & McGeary, J. E. (2009) · Journal of Abnormal Psychology · doi:10.1037/a0016198 · Cited by 179 · see citing works

5-HTTLPR Biases Amygdala Activity in Response to Masked Facial Expressions in Major Depression

Dannlowski, U., Ohrmann, P., Bauer, J., Deckert, J., Hohoff, C., Kugel, H., Arolt, V., Heindel, W. L., Kersting, A., Baune, B. T., et al. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301411 · Cited by 173 · see citing works

Gene–environment interactions predict cortisol responses after acute stress: implications for the etiology of depression

Alexander, N., Kuepper, Y., Schmitz, A., Osinsky, R., Kozyra, E., & Hennig, J. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.03.017 · Cited by 171 · see citing works

No association between genotype of the promoter region of serotonin transporter gene and serotonin transporter binding in human brain measured by PET

Shioe, K., Ichimiya, T., Suhara, T., Takano, A., Sudo, Y., Yasuno, F., Hirano, M., Shinohara, M., Kagami, M., Okubo, Y., et al. (2003) · Synapse · doi:10.1002/syn.10204 · Cited by 168 · see citing works

Gene–gene effects on central processing of aversive stimuli

Smolka, M. N., Fauth‐Bühler, M., Schumann, G., Vollstädt‐Klein, S., Hu, X.-Z., Moayer, M., Zimmer, A., Wrase, J., Flor, H., Mann, K. F., et al. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4001946 · Cited by 167 · see citing works

Training forgetting of negative material in depression.

Joormann, J., Hertel, P. T., LeMoult, J., & Gotlib, I. H. (2009) · Journal of Abnormal Psychology · doi:10.1037/a0013794 · Cited by 165 · see citing works

Genetic contributions of the serotonin transporter to social learning of fear and economic decision making

Crişan, L. G., Pană, S. E., Vulturar, R., Heilman, R. M., Szekely‐Copîndean, R. D., Drugă, B., Dragoş, N., & Miu, A. C. (2009) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsp019 · Cited by 164 · see citing works

The power of sample size and homogenous sampling: Association between the 5-HTTLPR serotonin transporter polymorphism and major depressive disorder

Hoefgen, B., Schulze, T. G., Ohlraun, S., von Widdern, O., Höfels, S., Groß, M., Heidmann, V., Kovalenko, S., Eckermann, A., Kölsch, H., et al. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.11.027 · Cited by 157 · see citing works

Increased Expression of the 5-HT Transporter Confers a Low- Anxiety Phenotype Linked to Decreased 5-HT Transmission

Jennings, K. A., Loder, M. K., Sheward, W. J., Pei, Q., Deacon, R. M. J., Benson, M. A., Olverman, H. J., Hastie, N. D., Harmar, A. J., Shen, S., et al. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.5356-05.2006 · Cited by 153 · see citing works

‘Negativity bias’ in risk for depression and anxiety: Brain–body fear circuitry correlates, 5-HTT-LPR and early life stress

Williams, L. M., Gatt, J. M., Schofield, P. R., Olivieri, G., Peduto, A. S., & Gordon, E. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.05.009 · Cited by 151 · see citing works

Invited Commentary: From Genome-Wide Association Studies to Gene-Environment-Wide Interaction Studies--Challenges and Opportunities

Khoury, M. J., & Wacholder, S. (2008) · American Journal of Epidemiology · doi:10.1093/aje/kwn351 · Cited by 148 · see citing works

Serotonin transporter genetic variation and biased attention for emotional word stimuli among psychiatric inpatients.

Beevers, C. G., Gibb, B. E., McGeary, J. E., & Miller, I. W. (2007) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.116.1.208 · Cited by 144 · see citing works

Genetic Variation in Serotonin Transporter Alters Resting Brain Function in Healthy Individuals

Rao, H., Gillihan, S. J., Wang, J., Korczykowski, M., Sankoorikal, G. M. V., Kaercher, K. A., Brodkin, E. S., Detre, J. A., & Farah, M. J. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.11.028 · Cited by 144 · see citing works

Glutamate and monoamine transporters: new visions of form and function

Torres, G. E., & Amara, S. (2007) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2007.05.002 · Cited by 144 · see citing works

Identifying Molecular Substrates in a Mouse Model of the Serotonin Transporter × Environment Risk Factor for Anxiety and Depression

Carola, V., Frazzetto, G., Pascucci, T., Audero, E., Puglisi‐Allegra, S., Cabib, S., Lesch, K., & Gross, C. T. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.08.013 · Cited by 141 · see citing works

G × E interaction in the organization of attachment: mothers’ responsiveness as a moderator of children’s genotypes

Barry, R. A., Kochanska, G., & Philibert, R. A. (2008) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2008.01935.x · Cited by 140 · see citing works

Serotonin Transporter Genotype (5-HTTLPR): Effects of Neutral and Undefined Conditions on Amygdala Activation

Heinz, A., Smolka, M. N., Braus, D. F., Wrase, J., Beck, A., Flor, H., Mann, K. F., Schumann, G., Büchel, C., Hariri, A. R., et al. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.08.019 · Cited by 133 · see citing works

Association of the functional [minus sign]1019C/G 5-HT 1A polymorphism with prefrontal cortex and amygdala activation measured with 3 T fMRI in panic disorder

Domschke, K., Braun, M., Ohrmann, P., Suslow, T., Kugel, H., Bauer, J., Hohoff, C., Kersting, A., Engelien, A., Arolt, V., et al. (2005) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145705005869 · Cited by 133 · see citing works

Serotonin Transporter Gene Polymorphism (5-HTTLPR) and Anxiety Reactivity in Daily Life: A Daily Process Approach to Gene-Environment Interaction

Gunthert, K. C., Conner, T. S., Armeli, S., Tennen, H. A., Covault, J., & Kranzler, H. R. (2007) · Psychosomatic Medicine · doi:10.1097/psy.0b013e318157ad42 · Cited by 132 · see citing works

Frontal-Limbic White Matter Pathway Associations with the Serotonin Transporter Gene Promoter Region (5-HTTLPR) Polymorphism

Pacheco, J. L., Beevers, C. G., Benavides, C., McGeary, J. E., Stice, E. M., & Schnyer, D. M. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0896-09.2009 · Cited by 132 · see citing works

Variation in the serotonin transporter gene modulates selective attention to threat.

Osinsky, R., Reuter, M., Küpper, Y., Schmitz, A., Kozyra, E., Alexander, N., & Hennig, J. (2008) · Emotion · doi:10.1037/a0012826 · Cited by 128 · see citing works

Serotonergic genes modulate amygdala activity in major depression

Dannlowski, U., Ohrmann, P., Bauer, J., Kugel, H., Baune, B. T., Hohoff, C., Kersting, A., Arolt, V., Heindel, W. L., Deckert, J., et al. (2006) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2006.00297.x · Cited by 128 · see citing works

Cognitive impact of genetic variation of the serotonin transporter in primates is associated with differences in brain morphology rather than serotonin neurotransmission

Jedema, H. P., Gianaros, P. J., Greer, P. J., Kerr, D. D., Liu, S., Higley, J. D., Suomi, S. J., Olsen, A. S., Porter, J. N., Lopresti, B. J., et al. (2009) · Molecular Psychiatry · doi:10.1038/mp.2009.90 · Cited by 128 · see citing works

Midbrain serotonin transporter binding potential measured with [11C]DASB is affected by serotonin transporter genotype

Reimold, M., Smolka, M. N., Schumann, G., Zimmer, A., Wrase, J., Mann, K. F., Hu, X., Goldman, D. A., Reischl, G., Solbach, C., et al. (2007) · Journal of Neural Transmission · doi:10.1007/s00702-006-0609-0 · Cited by 126 · see citing works

Children's Attentional Biases and <i>5-HTTLPR</i> Genotype: Potential Mechanisms Linking Mother and Child Depression

Gibb, B. E., Benas, J. S., Grassia, M., & McGeary, J. (2009) · Journal of Clinical Child &amp; Adolescent Psychology · doi:10.1080/15374410902851705 · Cited by 123 · see citing works

Parenting moderates a genetic vulnerability factor in longitudinal increases in youths' substance use.

Brody, G. H., Beach, S. R. H., Philibert, R. A., Chen, Y., Lei, M., Murry, V. M., & Brown, A. C. (2009) · Journal of Consulting and Clinical Psychology · doi:10.1037/a0012996 · Cited by 118 · see citing works

Allelic Variation of Serotonin Transporter Function Modulates the Brain Electrical Response for Error Processing

Fallgatter, A. J., Herrmann, M. J., Roemmler, J., Ehlis, A., Wagener, A., Heidrich, A., Ortega, G., Zeng, Y., & Lesch, K. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300409 · Cited by 117 · see citing works

Sleep Quality Varies as a Function of 5-HTTLPR Genotype and Stress

Brummett, B. H., Krystal, A. D., Ashley‐Koch, A. E., Kuhn, C. M., Zuchner, S. L., Siegler, I. C., Barefoot, J. C., Ballard, E. L., Gwyther, L. P., & Williams, R. B. (2007) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31814b8de6 · Cited by 115 · see citing works

Serotonin Transporter Genotype Modulates Social Reward and Punishment in Rhesus Macaques

Watson, K. K., Ghodasra, J. H., & Platt, M. L. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004156 · Cited by 113 · see citing works

Required sample size and nonreplicability thresholds for heterogeneous genetic associations

Moonesinghe, R., Khoury, M. J., Liu, T., & Ioannidis, J. P. A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705554105 · Cited by 106 · see citing works

Neuroimaging studies of serotonin gene polymorphisms: Exploring the interplay of genes, brain, and behavior

BROWN, S. M., & Hariri, A. R. (2006) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/cabn.6.1.44 · Cited by 101 · see citing works

Serotonin transporter gene variation impacts innate fear processing: acoustic startle response and emotional startle

Brocke, B., Armbruster, D., Müller, J., Hensch, T., Jacob, C., Lesch, K., Kirschbaum, C., & Strobel, A. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001908 · Cited by 98 · see citing works

Gender specific gene–environment interactions on laboratory-assessed aggression

Verona, E., Joiner, T. E., Johnson, F., & Bender, T. W. (2005) · Biological Psychology · doi:10.1016/j.biopsycho.2005.02.001 · Cited by 96 · see citing works

Researching Genetic Versus Nongenetic Determinants of Disease: A Comparison and Proposed Unification

Ioannidis, J. P. A., Loy, E. Y., Poulton, R., & Chia, K. S. (2009) · Science Translational Medicine · doi:10.1126/scitranslmed.3000247 · Cited by 95 · see citing works

Assessing the effect of interaction between an FTO variant (rs9939609) and physical activity on obesity in 15,925 Swedish and 2,511 Finnish adults

Jonsson, A. E., Renström, F., Lyssenko, V., Brito, E. C., Isomaa, B., Berglund, G., Nilsson, P. M., Groop, L., & Franks, P. W. (2009) · Diabetologia · doi:10.1007/s00125-009-1355-2 · Cited by 88 · see citing works

The serotonin transporter genotype is associated with intermediate brain phenotypes that depend on the context of eliciting stressor

Kalin, N. H., Shelton, S. E., Fox, A. S., Rogers, J., Oakes, T. R., & Davidson, R. J. (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.37 · Cited by 87 · see citing works

Association between the recombinant human serotonin transporter linked promoter region polymorphism and behavior in rhesus macaques during a separation paradigm

Spinelli, S., Schwandt, M. L., Lindell, S. G., Newman, T. K., Heilig, M. A., Suomi, S. J., Higley, J. D., Goldman, D. A., & Barr, C. S. (2007) · Development and Psychopathology · doi:10.1017/s095457940700048x · Cited by 86 · see citing works

Developmental disruption of serotonin transporter function impairs cerebral responses to whisker stimulation in mice

Esaki, T., Cook, M., Shimoji, K., Murphy, D. L., Sokoloff, L., & Holmes, A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501509102 · Cited by 85 · see citing works

The role of the serotonin transporter polymorphism for the endocrine stress response in newborns

Mueller‐Alcazar, A., Brocke, B., Fries, E., Lesch, K., & Kirschbaum, C. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.07.002 · Cited by 83 · see citing works

Functional coding variation in recombinant inbred mouse lines reveals multiple serotonin transporter-associated phenotypes

Carneiro, A. M. D., Airey, D. C., Thompson, B. J., Zhu, C.-B., Lu, L., Chesler, E. J., Erikson, K. M., & Blakely, R. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809449106 · Cited by 83 · see citing works

5HTTLPR Polymorphism and Enlargement of the Pulvinar: Unlocking the Backdoor to the Limbic System

Young, K. A., Holcomb, L. A., Bonkale, W. L., Hicks, P. B., Yazdani, U., & German, D. C. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.08.047 · Cited by 83 · see citing works

Early-emerging cognitive vulnerability to depression and the serotonin transporter promoter region polymorphism

Hayden, E. P., Dougherty, L. R., Maloney, B., Olino, T. M., Sheikh, H. I., Durbin, C. E., Nürnberger, J. I., Lahiri, D. K., & Klein, D. N. (2007) · Journal of Affective Disorders · doi:10.1016/j.jad.2007.07.028 · Cited by 75 · see citing works

Serotonin transporter promoter polymorphism influences topography of inhibitory motor control

Fallgatter, A. J., Jatzke, S., Bartsch, A. J., Hamelbeck, B., & Lesch, K. (1999) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145799001455 · Cited by 73 · see citing works

Allelic Variants of the Functional Promoter Polymorphism of the Human Serotonin Transporter Gene is Associated with Auditory Cortical Stimulus Processing

Gallinat, J., Senkowski, D., Wernicke, C., Juckel, G., Becker, I., Sander, T., Smolka, M. N., Hegerl, U., Rommelspacher, H., Winterer, G., et al. (2002) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300042 · Cited by 65 · see citing works

Serotonin transporter gene polymorphism (5-HTTLPR), environmental conditions, and developing negative emotionality and fear in early childhood

Pauli‐Pott, U., Friedl, S., Hinney, A., & Hebebrand, J. (2009) · Journal of Neural Transmission · doi:10.1007/s00702-008-0171-z · Cited by 63 · see citing works

Variants in Iron Metabolism Genes Predict Higher Blood Lead Levels in Young Children

Hopkins, M. R., Ettinger, A. S., Hernández‐Ávila, M., Schwartz, J. D., Téllez‐Rojo, M. M., Lamadrid‐Figueroa, H., Bellinger, D. C., Hu, H., & Wright, R. O. (2008) · Environmental Health Perspectives · doi:10.1289/ehp.11233 · Cited by 63 · see citing works

Allelic variation in serotonin transporter function associated with the intensity dependence of the auditory evoked potential

Strobel, A., Debener, S., Schmidt, D. G., Hünnerkopf, R., Lesch, K., & Brocke, B. (2002) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.10019 · Cited by 61 · see citing works

Serotonin transporter gene variation and stressful life events impact processing of fear and anxiety

Armbruster, D., Moser, D., Strobel, A., Hensch, T., Kirschbaum, C., Lesch, K., & Brocke, B. (2008) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145708009565 · Cited by 51 · see citing works

Polymorphisms of the Serotonin Transporter Gene and Their Relation to Premature Ejaculation in Individuals from Iran

Safarinejad, M. R. (2009) · The Journal of Urology · doi:10.1016/j.juro.2009.01.105 · Cited by 51 · see citing works

Gene-Environment-Wide Interaction Studies in Psychiatry

van Os, J., & Rutten, B. P. F. (2009) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2008.09060904 · Cited by 50 · see citing works

Why study gene–environment interactions?

Ordovás, J. M., & Tai, E. S. (2008) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e3282f6a809 · Cited by 46 · see citing works

Further Evidence for an Association of 5-HTTLPR with Intensity Dependence of Auditory-Evoked Potentials

Hensch, T., Wargelius, H., Herold, U., Lesch, K., Oreland, L., & Brocke, B. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301020 · Cited by 41 · see citing works

Blushing propensity in social anxiety disorder: influence of serotonin transporter gene variation

Domschke, K., Stevens, S., Beck, B., Baffa, A., Hohoff, C., Deckert, J., & Gerlach, A. L. (2008) · Journal of Neural Transmission · doi:10.1007/s00702-008-0090-z · Cited by 40 · see citing works

Altered timing of amygdala activation during sad mood elaboration as a function of 5-HTTLPR

Furman, D. J., Hamilton, J. P., Joormann, J., & Gotlib, I. H. (2010) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsq029 · Cited by 40 · see citing works

Baseline Brain Perfusion and the Serotonin Transporter Promoter Polymorphism

Viviani, R., Sim, E.-J., Lo, H., Beschoner, P., Osterfeld, N., Maier, C., Seeringer, A., Godoy, A. L. P. C., Rosa, A., Comas, D., et al. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.08.035 · Cited by 37 · see citing works

Neurotransmission-related genetic polymorphisms, negative affectivity traits, and gender predict tobacco abstinence symptoms across 44 days with and without nicotine patch.

Gilbert, D. G., Zuo, Y., Rabinovich, N. E., Riise, H., Needham, R., & Huggenvik, J. I. (2009) · Journal of Abnormal Psychology · doi:10.1037/a0015382 · Cited by 32 · see citing works

Serotonin transporter binding and genotype in the nonhuman primate brain using [C-11]DASB PET

Christian, B. T., Fox, A. S., Oler, J. A., Vandehey, N. T., Murali, D., Rogers, J., Oakes, T. R., Shelton, S. E., Davidson, R. J., & Kalin, N. H. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.05.090 · Cited by 30 · see citing works

Relationship of a 5-HT transporter functional polymorphism to 5-HT1A receptor binding in healthy women

Lee, M., Bailer, U. F., Frank, G., Henry, S., MELTZER, C. C., Price, J. C., Mathis, C. A., Putnam, K. T., Ferrell, R. E., Hariri, A. R., et al. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001680 · Cited by 29 · see citing works

Arguable Assumptions, Debatable Conclusions

Kaufman, J., Gelernter, J. E., Kaffman, A., Caspi, A., & Moffitt, T. E. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.07.041 · Cited by 27 · see citing works

Emotion-Induced Retrograde Amnesia Is Determined by a 5-HTT Genetic Polymorphism

Strange, B. A., Kroes, M. C. W., Roiser, J. P., Tan, G. C. Y., & Dolan, R. J. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.0834-08.2008 · Cited by 26 · see citing works

Gene-Environment Interactions and Depression

Koenen, K. C. (2009) · JAMA · doi:10.1001/jama.2009.1575 · Cited by 19 · see citing works

Gene-Environment Interactions and Depression

Lotrich, F. E. (2009) · JAMA · doi:10.1001/jama.2009.1576 · Cited by 17 · see citing works

Gene-Environment Interactions and Depression

Schwahn, C. (2009) · JAMA · doi:10.1001/jama.2009.1577 · Cited by 11 · see citing works

Gene-Environment Interactions and Depression

Rieckmann, N. (2009) · JAMA · doi:10.1001/jama.2009.1578 · Cited by 10 · see citing works

Resilience as a dynamic concept

Rutter, M. (2012) · Development and Psychopathology · doi:10.1017/s0954579412000028 · Cited by 1,853 · see citing works

Allele-specific FKBP5 DNA demethylation mediates gene–childhood trauma interactions

Klengel, T., Mehta, D., Anacker, C., Rex-Haffner, M., Pruessner, J. C., Pariante, C. M., Pace, T. W. W., Mercer, K. B., Mayberg, H. S., Bradley, B., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3275 · Cited by 1,447 · see citing works

Neurobiology of resilience

Russo, S. J., Murrough, J. W., Han, M.-H., Charney, D. S., & Nestler, E. J. (2012) · Nature Neuroscience · doi:10.1038/nn.3234 · Cited by 1,206 · see citing works

A Critical Review of the First 10 Years of Candidate Gene-by-Environment Interaction Research in Psychiatry

Duncan, L. E., & Keller, M. C. (2011) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.11020191 · Cited by 1,032 · see citing works

Current research trends in early life stress and depression: Review of human studies on sensitive periods, gene–environment interactions, and epigenetics

Heim, C., & Binder, E. B. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2011.10.032 · Cited by 986 · see citing works

All for One and One for All: Mental Disorders in One Dimension

Caspi, A., & Moffitt, T. E. (2018) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2018.17121383 · Cited by 918 · see citing works

The science of resilience: implications for the prevention and treatment of depression

Southwick, S. M., & Charney, D. S. (2012) · Science · doi:10.1126/science.1222942 · Cited by 875 · see citing works

Quality of acute psychedelic experience predicts therapeutic efficacy of psilocybin for treatment-resistant depression.

Roseman, L., Nutt, D. J., & Carhart-Harris, R. L. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00974 · Cited by 808 · see citing works

The neurobiology of depression: An integrated view

Dean, J., & Keshavan, M. (2017) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2017.01.025 · Cited by 765 · see citing works

The Genetics of Major Depression

Flint, J., & Kendler, K. S. (2014) · Neuron · doi:10.1016/j.neuron.2014.01.027 · Cited by 724 · see citing works

Stress, serotonin, and hippocampal neurogenesis in relation to depression and antidepressant effects

Mahar, I., Bambico, F. R., Mechawar, N., & Nobrega, J. N. (2014) · Neuroscience &amp; Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.11.009 · Cited by 694 · see citing works

Practitioner Review: What have we learnt about the causes of ADHD?

Thapar, A., Cooper, M., Eyre, O., & Langley, K. (2013) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2012.02611.x · Cited by 701 · see citing works

The role of early life stress as a predictor for alcohol and drug dependence

Enoch, M.-A. (2011) · Psychopharmacology · doi:10.1007/s00213-010-1916-6 · Cited by 668 · see citing works

Psychedelics and the essential importance of context

Carhart-Harris, R. L., Roseman, L., Haijen, E., Erritzoe, D., Watts, R., Branchi, I., & Kaelen, M. (2018) · Journal of Psychopharmacology · doi:10.1177/0269881118754710 · Cited by 657 · see citing works

Sensory Processing Sensitivity: A Review in the Light of the Evolution of Biological Responsivity

Aron, E. N., Aron, A., & Jagiellowicz, J. (2012) · Personality and Social Psychology Review · doi:10.1177/1088868311434213 · Cited by 645 · see citing works

The three-hit concept of vulnerability and resilience: toward understanding adaptation to early-life adversity outcome

Daskalakis, N. P., Bagot, R. C., Parker, K. J., Vinkers, C. H., & de Kloet, E. R. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.06.008 · Cited by 579 · see citing works

Testosterone and cortisol jointly regulate dominance: evidence for a dual-hormone hypothesis

Mehta, P. H., & Josephs, R. A. (2010) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.08.020 · Cited by 574 · see citing works

Anxiety disorders

Craske, M. G., Stein, M. B., Eley, T. C., Milad, M. R., Holmes, A., Rapee, R. M., & Wittchen, H.-U. (2017) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.24 · Cited by 652 · see citing works

The Emerging Field of Human Social Genomics

Slavich, G. M., & Cole, S. W. (2013) · Clinical Psychological Science · doi:10.1177/2167702613478594 · Cited by 523 · see citing works

Personality, Well-Being, and Health*

Friedman, H. S., & Kern, M. L. (2014) · Annual Review of Psychology · doi:10.1146/annurev-psych-010213-115123 · Cited by 530 · see citing works

Is depression an inflammatory disorder?

Raison, C. L., & Miller, A. H. (2011) · Current Psychiatry Reports · doi:10.1007/s11920-011-0232-0 · Cited by 524 · see citing works

Childhood and Adolescent Adversity and Cardiometabolic Outcomes: A Scientific Statement From the American Heart Association

Suglia, S. F., Koenen, K. C., Boynton-Jarrett, R., Chan, P. S., Clark, C. J., Danese, A., Faith, M. S., Goldstein, B. I., Hayman, L. L., Isasi, C. R., et al. (2018) · Circulation · doi:10.1161/cir.0000000000000536 · Cited by 518 · see citing works

A Unified Model of Depression: Integrating Clinical, Cognitive, Biological, and Evolutionary Perspectives

Beck, A. T., & Bredemeier, K. (2016) · Clinical Psychological Science · doi:10.1177/2167702616628523 · Cited by 510 · see citing works

The neurobiology of depression and antidepressant action

Willner, P., Scheel-Krüger, J., & Belzung, C. (2013) · Neuroscience &amp; Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.12.007 · Cited by 519 · see citing works

Risk factors for depression: an autobiographical review

Hammen, C. (2018) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-050817-084811 · Cited by 483 · see citing works

Child maltreatment and risk for psychopathology in childhood and adulthood

Jaffee, S. R. (2017) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-032816-045005 · Cited by 487 · see citing works

Overview of the Genetics of Major Depressive Disorder

Lohoff, F. W. (2010) · Current Psychiatry Reports · doi:10.1007/s11920-010-0150-6 · Cited by 498 · see citing works

The wear-and-tear of daily stressors on mental health

Charles, S. T., Piazza, J. R., Mogle, J., Sliwinski, M. J., & Almeida, D. M. (2013) · Psychological Science · doi:10.1177/0956797612462222 · Cited by 459 · see citing works

Mismatch or cumulative stress: Toward an integrated hypothesis of programming effects

Nederhof, E., & Schmidt, M. V. (2012) · Physiology &amp; Behavior · doi:10.1016/j.physbeh.2011.12.008 · Cited by 363 · see citing works

Fecundity of patients with schizophrenia, autism, bipolar disorder, depression, anorexia nervosa, or substance abuse vs their unaffected siblings

Power, R. A., Kyaga, S., Uher, R., MacCabe, J. H., Långström, N., Landen, M., McGuffin, P., Lewis, C. M., Lichtenstein, P., & Svensson, A. C. (2013) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.268 · Cited by 336 · see citing works

Clustering of depression and inflammation in adolescents previously exposed to childhood adversity

Miller, G. E., & Cole, S. W. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.02.034 · Cited by 331 · see citing works

Serotonin-prefrontal cortical circuitry in anxiety and depression phenotypes: pivotal role of pre- and post-synaptic 5-HT1A receptor expression

Albert, P. R., Vahid-Ansari, F., & Luckhart, C. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00199 · Cited by 321 · see citing works

Genetics of Human Social Behavior

Ebstein, R. P., Israel, S., Chew, S. H., Zhong, S., & Knafo, A. (2010) · Neuron · doi:10.1016/j.neuron.2010.02.020 · Cited by 323 · see citing works

The neural diathesis-stress model of schizophrenia revisited: an update on recent findings considering illness stage and neurobiological and methodological complexities

Pruessner, M., Cullen, A. E., Aas, M., & Walker, E. F. (2017) · Neuroscience &amp; Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.12.013 · Cited by 315 · see citing works

A database of tissue-specific rhythmically expressed human genes has potential applications in circadian medicine

Ruben, M. D., Wu, G., Smith, D. F., Schmidt, R. E., Francey, L. J., Lee, Y. Y., Anafi, R. C., & Hogenesch, J. B. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aat8806 · Cited by 314 · see citing works

Abnormal endogenous pain modulation is a shared characteristic of many chronic pain conditions

Staud, R. (2012) · Expert Review of Neurotherapeutics · doi:10.1586/ern.12.41 · Cited by 290 · see citing works

Adolescence: what do transmission, transition and translation have to do with it?

Casey, B. J., Duhoux, S., & Cohen, M. M. (2010) · Neuron · doi:10.1016/j.neuron.2010.08.033 · Cited by 297 · see citing works

Interaction between stress and the BDNFVal66Met polymorphism in depression: a systematic review and meta-analysis

Hosang, G. M., Shiles, C., Tansey, K. E., McGuffin, P., & Uher, R. (2014) · BMC Medicine · doi:10.1186/1741-7015-12-7 · Cited by 292 · see citing works

Efficacy of attention bias modification using threat and appetitive stimuli: a meta-analytic review

Beard, C., Sawyer, A. T., & Hofmann, S. G. (2012) · Behavior Therapy · doi:10.1016/j.beth.2012.01.002 · Cited by 291 · see citing works

Discovering imaging endophenotypes for major depression

Hasler, G., & Northoff, G. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.23 · Cited by 274 · see citing works

Gene–environment interactions: early life stress and risk for depressive and anxiety disorders

Nugent, N. R., Tyrka, A. R., Carpenter, L. L., & Price, L. H. (2011) · Psychopharmacology · doi:10.1007/s00213-010-2151-x · Cited by 269 · see citing works

Gene–Environment Interactions in Severe Mental Illness

Uher, R. (2014) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2014.00048 · Cited by 251 · see citing works

Peripuberty stress leads to abnormal aggression, altered amygdala and orbitofrontal reactivity and increased prefrontal MAOA gene expression

Márquez, C., Poirier, G. L., Cordero, M. I., Larsen, M. H., Groner, A., Marquis, J., Magistretti, P. J., Trono, D., & Sandi, C. (2013) · Translational Psychiatry · doi:10.1038/tp.2012.144 · Cited by 245 · see citing works

Strain Differences in Stress Responsivity Are Associated with Divergent Amygdala Gene Expression and Glutamate-Mediated Neuronal Excitability

Mozhui, K., Karlsson, R.-M., Kash, T. L., Ihne, J., Norcross, M., Patel, S., Farrell, M. R., Hill, E. E., Graybeal, C., Martin, K. P., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.5017-09.2010 · Cited by 226 · see citing works

Psychedelics in Psychiatry: Neuroplastic, Immunomodulatory, and Neurotransmitter Mechanisms

Inserra, A., De Gregorio, D., & Gobbi, G. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000056 · Cited by 232 · see citing works

The assessment and measurement of adult life stress: Basic premises, operational principles, and design requirements.

Harkness, K. L., & Monroe, S. M. (2016) · Journal of Abnormal Psychology · doi:10.1037/abn0000178 · Cited by 223 · see citing works

The reciprocal interaction between serotonin and social behaviour

Kiser, D., SteemerS, B., Branchi, I., & Homberg, J. R. (2012) · Neuroscience &amp; Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.12.009 · Cited by 214 · see citing works

Increased serotonin transporter gene ( <i>SERT</i> ) DNA methylation is associated with bullying victimization and blunted cortisol response to stress in childhood: a longitudinal study of discordant monozygotic twins

Ouellet-Morin, I., Wong, C. C. Y., Danese, A., Pariante, C. M., Papadopoulos, A. S., Mill, J., & Arseneault, L. (2013) · Psychological Medicine · doi:10.1017/s0033291712002784 · Cited by 207 · see citing works

Perceived social support moderates the link between threat-related amygdala reactivity and trait anxiety

Hyde, L. W., Gorka, A., Manuck, S. B., & Hariri, A. R. (2011) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2010.08.025 · Cited by 188 · see citing works

Family-Based Analysis of Genetic Variation Underlying Psychosis-Inducing Effects of Cannabis&lt;subtitle&gt;Sibling Analysis and Proband Follow-up&lt;/subtitle&gt;&lt;alt-title&gt;Genetic Variation Underlying Cannabis Effects&lt;/alt-title&gt;

van Winkel, R. (2011) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.152 · Cited by 183 · see citing works

Reduced Structural Connectivity of a Major Frontolimbic Pathway in Generalized Anxiety Disorder

Tromp, D. P. M., Grupe, D. W., Oathes, D. J., McFarlin, D. R., Hernandez, P. J., Kral, T. R. A., Lee, J. E., Adams, M., Alexander, A. L., & Nitschke, J. B. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.2178 · Cited by 184 · see citing works

The serotonin-BDNF duo: developmental implications for the vulnerability to psychopathology

Homberg, J. R., Molteni, R., Calabrese, F., & Riva, M. A. (2014) · Neuroscience &amp; Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.03.012 · Cited by 177 · see citing works

Inflammation, Sanitation, and Consternation: Loss of Contact With Coevolved, Tolerogenic Microorganisms and the Pathophysiology and Treatment of Major Depression

Raison, C. L., Lowry, C. A., & Rook, G. A. W. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.161 · Cited by 169 · see citing works

Genetic Determinants of Depression: Recent Findings and Future Directions

Dunn, E. C., Brown, R. C., Dai, Y., Rosand, J., Nugent, N. R., Amstadter, A. B., & Smoller, J. W. (2015) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000054 · Cited by 158 · see citing works

The neurobiological correlates of childhood adversity and implications for treatment

Tyrka, A. R., Burgers, D. E., Philip, N. S., Price, L. H., & Carpenter, L. L. (2013) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12143 · Cited by 142 · see citing works

Underlying Mechanisms of Gene–Environment Interactions in Externalizing Behavior: A Systematic Review and Search for Theoretical Mechanisms

Weeland, J., Overbeek, G., de Castro, B. O., & Matthys, W. (2015) · Clinical Child and Family Psychology Review · doi:10.1007/s10567-015-0196-4 · Cited by 138 · see citing works

Differential susceptibility in youth: evidence that 5-HTTLPR x positive parenting is associated with positive affect ‘for better and worse’

Hankin, B. L., Nederhof, E., Oppenheimer, C. W., Jenness, J., Young, J. F., Abela, J. R. Z., Smolen, A., Ormel, J., & Oldehinkel, A. J. (2011) · Translational Psychiatry · doi:10.1038/tp.2011.44 · Cited by 130 · see citing works

The neural underpinnings of cognitive flexibility and their disruption in psychotic illness

Waltz, J. A. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2016.06.005 · Cited by 122 · see citing works

Attention to Threats and Combat-Related Posttraumatic Stress Symptoms: Prospective Associations and Moderation by the Serotonin Transporter Gene

Wald, I., Degnan, K. A., Gorodetsky, E., Charney, D. S., Fox, N. A., Fruchter, E., Goldman, D., Lubin, G., Pine, D. S., & Bar-Haim, Y. (2013) · JAMA Psychiatry · doi:10.1001/2013.jamapsychiatry.188 · Cited by 125 · see citing works

Relational interventions for child maltreatment: Past, present and future perspectives

Toth, S. L., Gravener-Davis, J. A., Guild, D. J., & Cicchetti, D. (2013) · Development and Psychopathology · doi:10.1017/s0954579413000795 · Cited by 124 · see citing works

Combined role of childhood maltreatment, family history, and gender in the risk for alcohol dependence

Fenton, M. C., Geier, T., Keyes, K., Skodol, A. E., Grant, B. F., & Hasin, D. S. (2013) · Psychological Medicine · doi:10.1017/s0033291712001729 · Cited by 112 · see citing works

Cognitive Dysfunction in Depression – Pathophysiology and Novel Targets

Carvalho, A., Miskowiak, K., Hyphantis, T., Kohler, C., Alves, G., Bortolato, B., G. Sales, P., Machado-Vieira, R., Berk, M., & McIntyre, R. (2015) · CNS &amp; Neurological Disorders - Drug Targets · doi:10.2174/1871527313666141130203627 · Cited by 107 · see citing works

Is cognitive impairment following early life stress in severe mental disorders based on specific or general cognitive functioning?

Aas, M., Steen, N. E., Agartz, I., Aminoff, S. R., Lorentzen, S., Sundet, K., Andreassen, O. A., & Melle, I. (2012) · Psychiatry Research · doi:10.1016/j.psychres.2011.12.045 · Cited by 103 · see citing works

Role of tryptophan in microbiota-induced depressive-like behavior: evidence from tryptophan depletion study

Lukić, I., Getselter, D., Koren, O., & Elliott, E. (2019) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2019.00123 · Cited by 102 · see citing works

DNA methylation profiles within the serotonin transporter gene moderate the association of 5-HTTLPR and cortisol stress reactivity

Alexander, N., Wankerl, M., Hennig, J., Miller, R., Zänkert, S., Steudte-Schmiedgen, S., Stalder, T., & Kirschbaum, C. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.88 · Cited by 95 · see citing works

Does Psychedelic Therapy Have a Transdiagnostic Action and Prophylactic Potential?

Kočárová, R., Horáček, J., & Carhart-Harris, R. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.661233 · Cited by 96 · see citing works

The Serotonin Transporter Promoter Variant (5-HTTLPR), Stress, and Depression Meta-analysis Revisited: Evidence of Genetic Moderation

Karg, K., Burmeister, M., Shedden, K., & Sen, S. (2011) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.189 · Cited by 87 · see citing works

Gene-environment interactions between CRHR1 variants and physical assault in suicide attempts

Ben-Efraim, Y. J., Wasserman, D., Wasserman, J., & Sokolowski, M. (2011) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2011.00703.x · Cited by 83 · see citing works

The Genetics of Major Depression

Flint, J., & Kendler, K. S. (2014) · Neuron · doi:10.1016/j.neuron.2014.02.033 · Cited by 81 · see citing works

Brain-derived neurotrophic factor (<i>BDNF</i>) Val66Met polymorphism influences the association of the methylome with maternal anxiety and neonatal brain volumes

Chen, L., Pan, H., Tuan, T. A., Teh, A. L., MacIsaac, J. L., Mah, S. M., McEwen, L. M., Li, Y., Chen, H., Broekman, B. F. P., et al. (2015) · Development and Psychopathology · doi:10.1017/s0954579414001357 · Cited by 75 · see citing works

Glutamatergic mechanisms associated with stress-induced amygdala excitability and anxiety-related behavior

Masneuf, S., Lowery-Gionta, E., Colacicco, G., Pleil, K. E., Li, C., Crowley, N., Flynn, S., Holmes, A., & Kash, T. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.04.015 · Cited by 69 · see citing works

Effects of chronic interpersonal stress exposure on depressive symptoms are moderated by genetic variation at IL6 and IL1β in youth

Tartter, M., Hammen, C., Bower, J. E., Brennan, P. A., & Cole, S. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.01.003 · Cited by 66 · see citing works

Association of PER2 genotype and stressful life events with alcohol drinking in young adults

Blomeyer, D., Buchmann, A. F., Lascorz, J., Zimmermann, U. S., Esser, G., Desrivieres, S., Schmidt, M. H., Banaschewski, T., Schumann, G., & Laucht, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059136 · Cited by 65 · see citing works

Gene Expression and Methylation Signatures of<i>MAN2C1</i>are Associated with PTSD

Uddin, M., Galea, S., Chang, S.-C., Aiello, A. E., Wildman, D. E., de los Santos, R., & Koenen, K. C. (2011) · Disease Markers · doi:10.1155/2011/513659 · Cited by 60 · see citing works

Perceived discrimination, serotonin transporter linked polymorphic region status, and the development of conduct problems

Brody, G. H., Beach, S. R. H., Chen, Y.-F., Obasi, E., Philibert, R. A., Kogan, S. M., & Simons, R. L. (2011) · Development and Psychopathology · doi:10.1017/s0954579411000046 · Cited by 56 · see citing works

Emotion Regulation Moderates the Risk Associated with the 5-HTT Gene and Stress in Children

Ford, B. Q., Mauss, I. B., Troy, A. S., Smolen, A., & Hankin, B. (2014) · Emotion · doi:10.1037/a0036835 · Cited by 56 · see citing works

An interaction between a neuropeptide Y gene polymorphism and early adversity modulates endocrine stress responses

Witt, S. H., Buchmann, A. F., Blomeyer, D., Nieratschker, V., Treutlein, J., Esser, G., Schmidt, M. H., Bidlingmaier, M., Wiedemann, K., Rietschel, M., et al. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.12.015 · Cited by 54 · see citing works

A dimensional approach to modeling symptoms of neuropsychiatric disorders in the marmoset monkey

Oikonomidis, L., Santangelo, A. M., Shiba, Y., Clarke, F. H., Robbins, T. W., & Roberts, A. C. (2017) · Developmental Neurobiology · doi:10.1002/dneu.22446 · Cited by 54 · see citing works

The serotonin transporter gene polymorphism <i> 5‐ <scp>HTTLPR</scp> </i> moderates the effects of stress on attention‐deficit/hyperactivity disorder

van der Meer, D., Hartman, C. A., Richards, J., Bralten, J. B., Franke, B., Oosterlaan, J., Heslenfeld, D. J., Faraone, S. V., Buitelaar, J. K., & Hoekstra, P. J. (2014) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12240 · Cited by 51 · see citing works

Can pragmatic research, real-world data and digital technologies aid the development of psychedelic medicine?

Carhart-Harris, R. L., Wagner, A. C., Agrawal, M., Kettner, H., Rosenbaum, J. F., Gazzaley, A., Nutt, D. J., & Erritzoe, D. (2022) · Journal of Psychopharmacology · doi:10.1177/02698811211008567 · Cited by 51 · see citing works

On the developmental timing of stress: delineating sex-specific effects of stress across development on adult behavior.

Schroeder, A., Notaras, M., Du, X., & Hill, R. A. (2018) · Brain Sciences · doi:10.3390/brainsci8070121 · Cited by 50 · see citing works

Current developments and controversies: does the serotonin transporter gene-linked polymorphic region (5-httlpr) modulate the association between stress and depression?

Wankerl, M., Wüst, S., & Otte, C. (2010) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e32833f0e3a · Cited by 49 · see citing works

Childhood maltreatment and stress-related psychopathology: the epigenetic memory hypothesis

Lutz, P.-E., Almeida, D., Fiori, L., & Turecki, G. (2015) · Current Pharmaceutical Design · doi:10.2174/1381612821666150105124928 · Cited by 44 · see citing works

Interaction between COMT Val158Met polymorphism and childhood adversity affects reward processing in adulthood

Boecker-Schlier, R., Holz, N. E., Buchmann, A. F., Blomeyer, D., Plichta, M. M., Jennen-Steinmetz, C., Wolf, I., Baumeister, S., Treutlein, J., Rietschel, M., et al. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2016.02.006 · Cited by 42 · see citing works

Quantitative and Molecular Genetics of ADHD

Asherson, P., & Gurling, H. (2011) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2011_155 · Cited by 43 · see citing works

Genetic Differential Sensitivity to Social Environments: Implications for Research

Mitchell, C., McLanahan, S., Brooks-Gunn, J., Garfinkel, I., Hobcraft, J., & Notterman, D. (2013) · American Journal of Public Health · doi:10.2105/ajph.2013.301382 · Cited by 42 · see citing works

Identification of a novel gene regulating amygdala-mediated fear extinction

Gunduz-Cinar, O., Brockway, E., Lederle, L., Wilcox, T., Halladay, L. R., Ding, Y., Oh, H., Busch, E. F., Kaugars, K., Flynn, S., et al. (2019) · Molecular Psychiatry · doi:10.1038/s41380-017-0003-3 · Cited by 38 · see citing works

Serotonin transporter knockout rats show improved strategy set-shifting and reduced latent inhibition

Nonkes, L. J. P., van de Vondervoort, I. I. G. M., de Leeuw, M. J. C., Wijlaars, L. P., Maes, J. H. R., & Homberg, J. R. (2012) · Learning &amp; Memory · doi:10.1101/lm.025908.112 · Cited by 37 · see citing works

5-HTTLPR, anxiety and gender interaction moderates right amygdala volume in healthy subjects

Cerasa, A., Quattrone, A., Piras, F., Mangone, G., Magariello, A., Fagioli, S., Girardi, P., Muglia, M., Caltagirone, C., & Spalletta, G. (2014) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nst144 · Cited by 35 · see citing works

The influence of stress and early life adversity on addiction: Psychobiological mechanisms of risk and resilience

(2020) · International review of neurobiology · doi:10.1016/bs.irn.2020.03.012 · Cited by 34 · see citing works

Linking the serotonin transporter gene, family environments, hippocampal volume and depression onset: A prospective imaging gene × environment analysis

Little, K., Olsson, C. A., Youssef, G. J., Whittle, S., Simmons, J. G., Yücel, M., Sheeber, L. B., Foley, D. L., & Allen, N. B. (2015) · Journal of Abnormal Psychology · doi:10.1037/abn0000101 · Cited by 30 · see citing works

Genetic moderation of child maltreatment effects on depression and internalizing symptoms by serotonin transporter linked polymorphic region (<i>5-HTTLPR</i>), brain-derived neurotrophic factor (<i>BDNF</i>), norepinephrine transporter (<i>NET</i>), and corticotropin releasing hormone receptor 1 (<i>CRHR1</i>) genes in African American children

Cicchetti, D., & Rogosch, F. A. (2014) · Development and Psychopathology · doi:10.1017/s0954579414000984 · Cited by 29 · see citing works

Association between serotonin transporter genotype, brain structure and adolescent-onset major depressive disorder: A longitudinal prospective study

Little, K., Olsson, C. A., Whittle, S., Youssef, G. J., Byrne, M. L., Simmons, J. G., Yücel, M., Foley, D. L., & Allen, N. B. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.85 · Cited by 29 · see citing works

Citation bias and selective focus on positive findings in the literature on the serotonin transporter gene (5-HTTLPR), life stress and depression

de Vries, Y. A., Roest, A. M., Franzen, M., Munafò, M. R., & Bastiaansen, J. A. (2016) · Psychological Medicine · doi:10.1017/s0033291716000805 · Cited by 28 · see citing works

Interaction of dopamine transporter (DAT1) genotype and maltreatment for ADHD: a latent class analysis

Li, J. J., & Lee, S. S. (2012) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2012.02563.x · Cited by 28 · see citing works

What the alcohol doctor ordered from the neuroscientist

Heilig, M., & Leggio, L. (2016) · Progress in Brain Research · doi:10.1016/bs.pbr.2015.07.023 · Cited by 25 · see citing works

The effect of childhood trauma on serum BDNF in bipolar depression is modulated by the serotonin promoter genotype

Benedetti, F., Ambrée, O., Locatelli, C., Lorenzi, C., Poletti, S., Colombo, C., & Arolt, V. (2017) · Neuroscience Letters · doi:10.1016/j.neulet.2017.07.043 · Cited by 18 · see citing works

Serotonin transporter genotype differentially modulates neural responses to emotional words following tryptophan depletion in patients recovered from depression and healthy volunteers

Roiser, J. P., Levy, J., Fromm, S. J., Goldman, D., Hodgkinson, C. A., Hasler, G., Sahakian, B. J., & Drevets, W. C. (2012) · Journal of Psychopharmacology · doi:10.1177/0269881112442789 · Cited by 18 · see citing works

Gene–Environment Interactions in the Etiology of Human Violence

Laucht, M., Brandeis, D., & Zohsel, K. (2013) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2013_260 · Cited by 18 · see citing works

Allostatic interoception and brain health: From neurodegeneration to social adversities

Migeot, J., & Ibáñez, A. (2025) · Encyclopedia of the Human Brain · doi:10.1016/b978-0-12-820480-1.00025-5 · Cited by 10 · see citing works